Omid C Farokhzad

US Patent:

7727969, Jun 1, 2010

Filed:

Jun 6, 2003

Appl. No.:

10/456978

Inventors:

Omid C. Farokhzad - Boston MA, US
Sang Yong Jon - Cambridge MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/7088
A61K 9/14
C12Q 1/68
C12N 11/08
C12N 11/04
G01N 33/545
G01N 33/549
A61K 38/00
C07K 17/04
C07K 17/08

US Classification:

514 44R, 424486, 424489, 435 6, 435180, 435182, 436531, 436535, 514 2, 530817

Abstract:

The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.

US Patent:

8193334, Jun 5, 2012

Filed:

Oct 5, 2009

Appl. No.:

12/573411

Inventors:

Liangfang Zhang - San Diego CA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US

Assignee:

The Brigham and Women's Hospital - Boston MA
Massachusetts Institute of Technologoy - Cambridge MA

International Classification:

C07H 21/04
C07H 21/02
C12N 15/63
A61K 48/00
A61K 43/00

US Classification:

536 245, 536 231, 536 2431, 536 2433, 4353201, 514 44, 424 111

Abstract:

A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.

US Patent:

8277812, Oct 2, 2012

Filed:

Apr 22, 2009

Appl. No.:

12/428408

Inventors:

Matteo Iannacone - Boston MA, US
Frank Alexis - Brighton MA, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Jinjun Shi - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/395

US Classification:

4241841, 4241931

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8323698, Dec 4, 2012

Filed:

Sep 1, 2010

Appl. No.:

12/873692

Inventors:

Frank X. Gu - Waterloo, CA
Omid C. Farokhzad - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Benjamin A. Teply - Omaha NE, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 9/14
A61K 9/51

US Classification:

424489, 514883, 977773, 977906, 977915

Abstract:

The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates.

US Patent:

8343497, Jan 1, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428381

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8343498, Jan 1, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428395

Inventors:

Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Jinjun Shi - Boston MA, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8367113, Feb 5, 2013

Filed:

May 15, 2007

Appl. No.:

11/803843

Inventors:

Frank X. Gu - Cambridge MA, US
Benjamin A. Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 9/14
A61K 9/51

US Classification:

424489, 514883, 977773, 977906, 977915

Abstract:

The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates.

US Patent:

8562998, Oct 22, 2013

Filed:

Oct 9, 2009

Appl. No.:

13/123884

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.