Ning H Huang

US Patent:

6781044, Aug 24, 2004

Filed:

Aug 17, 2001

Appl. No.:

09/932328

Inventors:

Raymond L. Rodriguez - Davis CA
Ning Huang - Davis CA

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 1582

US Classification:

8003202, 800287, 800300, 800278, 435193, 435204, 435209, 4354301, 435468

Abstract:

A plant transformation vector for transforming host plant cells with a chimeric selectable marker gene is disclosed. The gene includes, operatively linked in sequence in a 5â to 3â direction, (i) a DNA promoter sequence from the rice beta-glucanase 9 (gns9) gene; (ii) a selectable marker gene, and (iii) a 3â untranslated terminator region. Also disclosed are a vector pair containing the transformation vector, a method of obtaining transformed monocots whose seeds produce a selected heterologous protein during sed germination, and a plant whose cells are transformed with the chimeric selectable marker gene.

US Patent:

6991824, Jan 31, 2006

Filed:

Feb 14, 2002

Appl. No.:

10/077381

Inventors:

Ning Huang - Davis CA, US
Raymond L. Rodriguez - Davis CA, US
Frank E. Hagie - Sacramento CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

A21D 2/26

US Classification:

426622, 426629

Abstract:

The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.

US Patent:

7138150, Nov 21, 2006

Filed:

Aug 13, 2003

Appl. No.:

10/639781

Inventors:

Ning Huang - Davis CA, US
Jianmin Huang - Davis CA, US
Delia R. Bethell - Sacramento CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

A61K 9/68
A61K 9/20
C12N 15/12

US Classification:

426 3, 424 9463, 424440, 424464

Abstract:

This invention concerns a method of making an anti-infective composition for oral administration using an agent selected from the group consisting of lactoferrin protein and lysozyme protein. The method comprises three steps. The nucleic acid, which encodes a lactoferrin or lysozyme protein, is expressed in a monocot seed. The protein is isolated from the seed. This protein isolation compromises greater than 3% of the total soluble protein in the monocot seed. The protein is then formulated for oral administration.

US Patent:

7304208, Dec 4, 2007

Filed:

Apr 11, 2003

Appl. No.:

10/411395

Inventors:

Ning Huang - Davis CA, US
Raymond L. Rodriquez - Davis CA, US
Frank E. Hagie - Sacramento CA, US
David M. Stalker - Woodland CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 15/82
A01H 5/00
C07H 21/04

US Classification:

800288, 800287

Abstract:

A method of producing human serum albumin (HSA) in monocot plant seeds, by transforming a monocot plant cell with a chimeric gene containing a promoter from the gene of a maturation-specific monocot plant storage protein, a first DNA sequence operably linked to the promoter and encoding a signal sequence, and a second DNA sequence linked in translation frame with the first DNA sequence and encoding HSA, where the first DNA sequence and the second DNA sequence together encode a fusion protein containing an N-terminal signal sequence and the HSA; growing a monocot plant from the transformed monocot plant cell for a time sufficient to produce seeds containing the HSA; and harvesting the seeds from the plant.

US Patent:

7417178, Aug 26, 2008

Filed:

Aug 12, 2003

Appl. No.:

10/639835

Inventors:

Ning Huang - Davis CA, US
Raymond L. Rodriguez - Davis CA, US
Frank E. Hagie - Sacramento CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 15/82
A01H 5/00
C07H 21/04

US Classification:

800288, 800287, 800298, 8003202, 536 241

Abstract:

The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.

US Patent:

7589252, Sep 15, 2009

Filed:

Mar 16, 2005

Appl. No.:

11/083617

Inventors:

Ning Huang - Davis CA, US
Daichang Yang - Davis CA, US
Robert J. Schmidt - La Jolla CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 15/82
C12N 5/04

US Classification:

800278, 800287, 800290

Abstract:

The invention relates to transgenic plants that demonstrate enhanced expression of a plant transcription factor under the control of a seed specific promoter such that expression of the transcription factor activates transcription of a native or non-native coding sequence in the plant. The invention further relates to a method of generating such transgenic plants and methods for enhancing the level of expression of a selected heterologous protein in seeds of such transgenic plants.

US Patent:

7718851, May 18, 2010

Filed:

Apr 21, 2008

Appl. No.:

12/148779

Inventors:

Ning Huang - Davis CA, US
Raymond L. Rodriguez - Davis CA, US
Frank E. Hagie - Sacramento CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 15/82
C12P 21/00
A01H 5/00

US Classification:

800288, 435 691, 800298

Abstract:

The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.

US Patent:

8158857, Apr 17, 2012

Filed:

Mar 31, 2010

Appl. No.:

12/751869

Inventors:

Ning Huang - Davis CA, US
Raymond L. Rodriguez - Davis CA, US
Frank E. Hagie - Sacramento CA, US
David M. Stalker - Woodland CA, US

Assignee:

Ventria Bioscience - Sacramento CA

International Classification:

C12N 15/82
A01H 5/00
A23J 3/18
C07K 4/12
C07K 14/765

US Classification:

800288, 800298, 800320, 426615, 426618, 426622, 530363

Abstract:

The invention is directed to monocot plant seed products comprising human serum albumin, and to methods of making said monocot plant seed products comprising human serum albumin and to therapeutic compositions comprising them.