Nina D Berova

US Patent:

6844451, Jan 18, 2005

Filed:

Jul 7, 2003

Appl. No.:

10/615346

Inventors:

Dirk Lichtblau - Halle, DE
Nina Berova - New York NY, US
John Berger - Oro Valley AZ, US
Koji Nakanishi - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D30777
C07D30793

US Classification:

549297, 549298

Abstract:

A method of isolating terpene trilactones from plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.

US Patent:

20030031736, Feb 13, 2003

Filed:

Jul 11, 2002

Appl. No.:

10/194089

Inventors:

Dirk Lichtblau - Halle/S., DE
Nina Berova - New York NY, US
John Berger - Oro Valley AZ, US
Koji Nakanishi - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York

International Classification:

C07D311/78
C07D498/14
A61K035/78

US Classification:

424/752000, 549/280000

Abstract:

A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.

US Patent:

20050136136, Jun 23, 2005

Filed:

Jan 14, 2005

Appl. No.:

11/036409

Inventors:

Dirk Lichtblau - Halle/S., DE
Nina Berova - New York NY, US
John Berger - Oro Valley AZ, US
Koji Nakanishi - New York NY, US

Assignee:

The Trustees of Columbia University - New York NY

International Classification:

C07D493/14
A61K035/78

US Classification:

424752000, 549275000, 549297000

Abstract:

A method of isolating terpene trilactones from plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.

US Patent:

20080306145, Dec 11, 2008

Filed:

Nov 23, 2005

Appl. No.:

11/791422

Inventors:

Koji Nakanishi - New York NY, US
Nina Berova - New York NY, US
Katsunori Tanaka - Osaka, JP

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 31/343
C07D 307/77
A61P 7/00

US Classification:

514468, 549297

Abstract:

The present invention relates to synthesis of Cnatural ginkgolide derivatives and Cf-seco-gingkolide derivatives from the corresponding lactols which are selectively obtained using NaBH.

US Patent:

20090156668, Jun 18, 2009

Filed:

Mar 21, 2005

Appl. No.:

10/593427

Inventors:

Ottavio V. Vitolo - Cambridge MA, US
Koji Nakanishi - New York NY, US
Michael L. Shelanski - Brooklyn NY, US
Sonja Krane - Del Mar CA, US
Ottavio Arancio - New York NY, US
Stanislav Jaracz - Trinec, CZ
Nina D. Berova - New York NY, US

Assignee:

The Trustees Of Columbia University In The City Of New York - New York NY

International Classification:

A61K 31/365
C07D 493/22
A61K 51/00
C12N 5/02

US Classification:

514462, 549265, 424 165, 435375

Abstract:

The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents.

Author:

Nina Berova

ISBN #:

0471185825

Author:

Nina Berova

ISBN #:

0471330035