Solomon Langermann - Baltimore MD Scott Koenig - Rockville MD John Smit - Richmond, CA Nilofer Qureshi - Madison WI
Assignee:
Univ. of British Columbia - Vancouver
International Classification:
A61K 3900
US Classification:
4241841, 4242831, 514 53, 514 54
Abstract:
The present invention provides immunogenic compositions and methods for inducing enhanced immune responses using an antigen by use of an adjuvant comprising a member selected from a Caulobacter (in particular, ) LPS or a fragment or derivative thereof.
Kuni K. Takayama - Madison WI Nilofer Qureshi - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 3100 C07H 2100 C07H 1300 C07H 500
US Classification:
514 53
Abstract:
Compounds are disclosed which are useful in a method of treating animals to protect them from the toxic effects of Gram negative endotoxin. They include the diphosphoryl lipid A (DPLA) which can be obtained from R. sphaeroides ATCC 17023 grown at about 26. degree. C.
Method Of Stimulating The Immune Systems Of Animals And Compositions Useful Therefor
Kuni K. Takayama - Madison WI Nilofer Qureshi - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 31715 A61K 3170 A61K 3900 C12N 100
US Classification:
514 53
Abstract:
A method is disclosed for stimulating the immune systems of animals with non-toxic lipid A derivatives. The derivatives include the lipopolysaccharide (LPS) and diphosphoryl lipid A (DPLA) for Rhodopsuedomonas.