The present disclosure relates to compounds that inhibit SETBP1 or XP01 activities. Also disclosed are methods of using such compounds to increase the expression of embryonic and fetal hemoglobin molecules, and to treat sickle cell disease and β-thalassemia. The present invention relates to unexpected findings that transcription factor SETBP1 regulates embryonic and fetal hemoglobin repression, and inhibition of SETBP1 can induce the expression of embryonic and fetal hemoglobins.
Setbp1 Inhibitors For The Treatment Of Myeloid Neoplasms And Solid Tumors
Chemical compounds for the treatment of myeloid neoplasms and solid tumors are described, where the compounds were identified through a screening process assessing the binding affinity of the compounds to a synthesized fragment of Setbp1 protein.
Name / Title
Company / Classification
Phones & Addresses
Nhu Nguyen Director
VIET NALANDA FOUNDATION
8201 Westminster Blvd STE 200, Westminster, CA 92683 112 Stanford Ct, Irvine, CA 92612 14905 Coles Chance Rd, Gaithersburg, MD 20878
Medicine Doctors
Dr. Nhu Tuyet T Nguyen, Washington DC - MD (Doctor of Medicine)
Dr. Nguyen graduated from the Texas A & M University Health Science Center Colle of Medicine in 1999. She works in Houston, TX and specializes in Ophthalmology. Dr. Nguyen is affiliated with Memorial Hermann Texas Medical Center and West Oaks Hospital.
Hospitalists Group Of El PasoEl Paso Hospitalist Services 1625 Medical Ctr Dr, El Paso, TX 79902 915 521-8686 (phone), 915 546-9800 (fax)
Education:
Medical School American University of the Caribbean School of Medicine Graduated: 2003
Conditions:
Acute Bronchitis Acute Sinusitis Atrial Fibrillation and Atrial Flutter Benign Polyps of the Colon Bronchial Asthma
Languages:
English Spanish
Description:
Dr. Nguyen graduated from the American University of the Caribbean School of Medicine in 2003. She works in El Paso, TX and specializes in Family Medicine. Dr. Nguyen is affiliated with Hospitals Of Providence Memorial Campus, Hospitals Of Providence Sierra Campus and Kindred Hospital.
Nhu Nguyen, a 53-year-old mother and grandmother of two, was working at Crystal Nails & Spa on West Flamingo Road last Saturday afternoon, when a female customer decided she was going to skip her bill after her credit card was repeatedly declined, Nguyens boyfriend of 13 years told the Las Vega
Police this morning report Nhu Nguyen of Dorchester, 19, was arrested in Portland, Maine, last night in connection with the death of Derek Matulina, 19, of Dorchester, who was gunned down at the Savin Hill T station on Saturday.