Neil C Miller

US Patent:

47789093, Oct 18, 1988

Filed:

May 11, 1984

Appl. No.:

6/609272

Inventors:

Barry L. Karger - Chestnut Hill MA
Binyamin Feibush - Needham MA
Neil T. Miller - West Newton MA
Alvaro Figueroa - Boston MA

Assignee:

Northeastern University - Boston MA

International Classification:

C07F 708
C07F 718
C07F 710

US Classification:

556450

Abstract:

Fast high resolution separations of biopolymers with retention of biological activity have been achieved by hydrophobic interaction chromatography using trialkoxy silyl ethers of the general formula (RO). sub. 3 Si--(CH. sub. 2). sub. m --O--(CH. sub. 2 CH. sub. 2 O). sub. n --(CH. sub. 2). sub. p R' chemically bonded to silica-based chromatographic supports. In the formula R is alkyl of from one to five carbons, m is an integer from two to five, n is an integer from one to five, p is an integer from zero of ten, and R' is methyl, phenyl, or substituted phenyl. Stable and reproducible bonded phases are prepared in a novel solventless procedure by a bonding process which uses a defined and controlled amount of water on the silica surface and a gaseous or volatile basic catalyst such as ammonia to produce a controlled amount of silane polymerization and cross-linking in addition to extensive bonding between silane and silica. High performance liquid chromatography on such weakly hydrophobic stationary phases using aqueous eluents and decreasing salt gradients under mild conditions permits high speed, high resolution separations of biopolymers such as proteins without destruction of their biological activity and without column degradation. Size exclusion chromatography can also be performed on these phases using low ionic strength eluents.

US Patent:

49963430, Feb 26, 1991

Filed:

Oct 13, 1988

Appl. No.:

7/257740

Inventors:

Barry L. Karger - Chestnut Hill MA
Binyamin Feibush - Needham MA
Neil T. Miller - West Newton MA
Alvaro Figueroa - Boston MA

Assignee:

Northeastern University - Boston MA

International Classification:

C07F 708
C07F 718

US Classification:

556445

Abstract:

Fast high resolution separations of biopolymers with retention of biological activity have been achieved by hydrophobic interaction chromatography using trialkoxy silyl ethers of the general formula (RO). sub. 3 Si--(CH. sub. 2). sub. m --O--(CH. sub. 2 CH. sub. 2 O). sub. n 13 (CH. sub. 2). sub. p R' chemically bonded to silica-based chromatographic supports. In the formula R is alkyl of from one to five carbons, m is an integer from two to five, n is an integer from one to five, p is an integer from zero of ten, and R' is methyl, phenyl, or substituted phenyl. Stable and reproducible bonded phases are prepared in a novel solventless procedure by a bonding process which uses a defined and controlled amount of water on the silica surface and a gaseous or volatile basic catalyst such as ammonia to produce a controlled amount of silane polymerization and cross-linking in addition to extensive bonding between silane and silica. High performance liquid chromatography on such weakly hydrophobic stationary phases using aqueous eluents and decreasing salt gradients under mild conditions permits high speed, high resolution separations of biopolymers such as proteins without destruction of their biological activity and without column degradation. Size exclusion chromatography can also be performed on these phases using low ioinic strength eluents.

US Patent:

44894392, Dec 18, 1984

Filed:

Sep 20, 1982

Appl. No.:

6/420282

Inventors:

Donald T. Scholz - Wayland MA
Neil A. Miller - Newtonville MA

Assignee:

Scholz Research & Development - Waltham MA

International Classification:

H03G 300

US Classification:

381 63

Abstract:

A stereo or two channel electronic reverberation device is disclosed comprising an analog delay device which receives audio signals and provides delayed output signals at a plurality of outputs, with the time delay period of each output being different from the delay period of other outputs. Two summing devices each receive inputs from different combinations of the analog delay device outputs to provide two different signals having different reverb components. An additional output delay device is also provided with receives the last output from the analog delay device, delays this signal a time period substantially greater than the time period between any two adjacent analog delay device outputs, and provides this substantially greater delayed signal to only one of said summing devices. The circuit includes a synthetic doubler which provides an output cyclicly varying in pitch from its input. Two output mixers provide reverb alone, doubler signal alone or both reverb and doubling.

US Patent:

45091919, Apr 2, 1985

Filed:

Sep 20, 1982

Appl. No.:

6/420281

Inventors:

Neil A. Miller - Newtonville MA

Assignee:

Scholz Research & Development - Waltham MA

International Classification:

H04R 300

US Classification:

381 63

Abstract:

A stereo or two channel electronic reverberation device is disclosed comprising an analog delay device which receives audio signals and provides delayed output signals at a plurality of outputs, with the time delay period of each output being different from the delay period of other outputs. Two summing devices each receive inputs from different combinations of the analog delay device outputs to provide two different signals having different reverb components. An additional output delay device is also provided which receives the last output from the analog delay device, delays this signal a time period substantially greater than the time period between any two adjacent analog delay device outputs, and provides this substantially greater delayed signal to only one of said summing devices.

Author:

Neil Miller

ISBN #:

0060973080

Author:

Neil Miller

ISBN #:

0810955083

Author:

Neil Miller

ISBN #:

0824794443

Author:

Neil Miller

ISBN #:

0871133040

Author:

Neil Miller

ISBN #:

0960144420

Author:

Neil Miller

ISBN #:

0960144412

Author:

Neil R. Miller

ISBN #:

0683060201

Author:

Neil R. Miller

ISBN #:

0683060228

Address:

38 Warrenton Rd, Haverhill, MA 01832

Phone:

978 469-9490

VIN:

5TFUM5F17AX014845

Make:

TOYOTA

Model:

TUNDRA

Year:

2010