Neil Robert Hackett

US Patent:

7368553, May 6, 2008

Filed:

Oct 21, 2004

Appl. No.:

10/971643

Inventors:

Ronald G. Crystal - New York NY, US
Neil R. Hackett - New York NY, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C07H 21/04
C12P 21/06
C12N 15/00
C12N 5/00
C12N 15/74

US Classification:

536 235, 435 691, 4352523, 4353201, 435325, 435471

Abstract:

The invention provides an isolated or purified nucleic acid molecule comprising SEQ ID NO:1, which contains cDNA comprising exons 1-5 of a vascular endothelial growth factor (VEGF) joined to genomic DNA comprising introns 5, 6, and 7 and exons 6, 7, and 8 of VEGF and a mutation in one or more of the splice donor, branch point, and splice acceptor regions, which promotes the production of a VEGFisoform. Expression constructs, compositions, and cells comprising such a nucleic acid molecule also are provided by the invention.

US Patent:

7687613, Mar 30, 2010

Filed:

Aug 27, 2003

Appl. No.:

10/649457

Inventors:

Ronald G. Crystal - New York NY, US
Neil R. Hackett - New York NY, US
Yadi Tan - Zhi-Jiang, CN

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12N 15/11
A61K 48/00

US Classification:

536 231, 514 44

Abstract:

The invention provides a gene transfer vector comprising a humanized nucleic acid sequence encoding an immunogenic portion of one or more exotoxins of and a heterologous sorting signal. The invention also provides a method of producing an immune response against in a host comprising administering to the host the gene transfer vector.

US Patent:

20100119474, May 13, 2010

Filed:

Mar 6, 2008

Appl. No.:

12/529838

Inventors:

Ronald G. Crystal - New York NY, US
Neil R. Hackett - New York NY, US
Adriana Heguy - Forest Hills NY, US
Ben-Gary Harvey - West Hempstead NY, US
Philip L. Leopold - Basking Ridge NJ, US
Ann E. Tilley - New York NY, US
Timothy O'Connor - New York NY, US

Assignee:

Cornell University - Ithaca NY

International Classification:

A61K 38/20
G01N 33/53
A61K 38/45
A61K 38/47
A61K 38/44
A61K 38/21
A61P 11/00

US Classification:

424 852, 435 721, 424 945, 424 9461, 424 944, 424 855

Abstract:

The invention provides a method of determining the likelihood that a smoker will or will not develop chronic obstructive pulmonary disease (COPD) by obtaining a sample from the smoker, analyzing the sample for the expression of a set of biomarkers associated with COPD, and comparing the expression pattern determined in the sample with a standard expression pattern to determine the likelihood that the smoker will or will not develop COPD. The invention further provides a composition, a method of treatment, and methods of determining the efficacy of treatment for COPD.

US Patent:

61657549, Dec 26, 2000

Filed:

Jun 8, 1999

Appl. No.:

9/328020

Inventors:

Ronald G. Crystal - Potomac MD
Xiaohuai Zhou - New York NY
Neil R. Hackett - New York NY
Todd K. Rosengart - Highland Park IL

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12P 2100
C12N 1563
C12N 1585
A61K 4800
C07H 2104

US Classification:

435 691

Abstract:

The present invention provides a method of expressing an exogenous nucleic acid in a mammal. The method comprises non-systemically administering to a non-neuronal tissue of said mammal an exogenous nucleic acid operatively linked to a promoter. The exogenous nucleic acid is proximal to at least one native parvoviral inverted terminal repeat and does not require encapsidation. The expression of the exogenous nucleic acid in the tissue is not substantially diminished at 28 days after administration of the exogenous nucleic acid.

US Patent:

20220387627, Dec 8, 2022

Filed:

Jun 2, 2022

Appl. No.:

17/830583

Inventors:

- West Byfleet, GB
Neil R. Hackett - Santa Monica CA, US

International Classification:

A61K 48/00
C12N 15/861
C07K 14/005

Abstract:

The present disclosure relates to AAV gene therapy vectors, AAV replicons, and pharmaceutical compositions for delivering a human HDAC8 gene to a subject for treating Cornelia de Lange Syndrome. In addition, methods of treatment and gene transfer are provided.

Author:

Neil Hackett

ISBN #:

0321423321

Author:

Neil J. Hackett

ISBN #:

0205558429

Author:

Neil J. Hackett

ISBN #:

0205558437

Author:

Neil J. Hackett

ISBN #:

0205558410

Author:

Neil J. Hackett

ISBN #:

0205573754

Author:

Neil J. Hackett

ISBN #:

0205574300

Author:

Neil J. Hackett

ISBN #:

0205574319

Author:

Neil J. Hackett

ISBN #:

0321005295