Neil J Ashweek from 1802 Craigmore Ave, Escondido, CA 92027, age 49

Us Patents

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto
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US Patent:

8263588, Sep 11, 2012
Filed:

Apr 4, 2008
Appl. No.:

12/594815
Inventors:

Graham Beaton - Poway CA, US
Mi Chen - San Diego CA, US
Timothy Richard Coon - Carlsbad CA, US
Todd Ewing - San Diego CA, US
Wanlong Jiang - San Diego CA, US
Jinghua Yu - San Marcos CA, US
Willy Moree - San Diego CA, US
Warren Wade - San Diego CA, US
Liren Zhao - San Diego CA, US
Yun-fei Zhu - San Diego CA, US
Martin Rowbottom - San Diego CA, US
Neil Ashweek - San Diego CA, US
Assignee:

Neurocrine Biosciences, Inc. - San Diego CA
International Classification:

C07D 213/61
C07D 213/84
C07D 401/12
C07D 403/12
A61K 31/435
A61P 35/00
US Classification:

51421109, 51421301, 5142305, 514269, 514311, 514314, 540552, 540593, 544105, 544315, 546165
Abstract:

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Compounds, Pharmaceutical Composition And Methods Relating Thereto
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US Patent:

8293729, Oct 23, 2012
Filed:

Jun 23, 2010
Appl. No.:

12/821231
Inventors:

Brian Dyck - San Diego CA, US
Joe A. Tran - San Marcos CA, US
Junko Tamiya - Carlsbad CA, US
Florence Jovic - Los Angeles CA, US
Troy Vickers - San Diego CA, US
Chen Chen - San Diego CA, US
Nicole Harriott - San Diego CA, US
Timothy Coon - Carlsbad CA, US
Neil J. Ashweek - Escondido CA, US
Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein
Neurocrine Biosciences Inc. - San Diego CA
International Classification:

C07D 211/68
C07D 401/10
C07D 413/14
A61K 31/15
US Classification:

514218, 5142372, 51425301, 51425313, 51425505, 5142601, 51426411, 514269, 514273, 514275, 514303, 514316, 540575, 544128, 544278, 544279, 544298, 544320, 544323, 544364, 544409, 546118, 546187, 546188
Abstract:

New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I):.

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto
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US Patent:

8481738, Jul 9, 2013
Filed:

Nov 10, 2011
Appl. No.:

13/293943
Inventors:

Graham Beaton - Poway CA, US
Mi Chen - San Diego CA, US
Timothy Richard Coon - Carlsbad CA, US
Todd Ewing - San Diego CA, US
Wanlong Jiang - San Diego CA, US
Richard Lowe - Oakland CA, US
Willy Moree - San Diego CA, US
Nicole Smith - San Diego CA, US
Warren Wade - San Diego CA, US
Liren Zhao - San Diego CA, US
Yun-fei Zhu - San Diego CA, US
Martin Rowbottom - San Diego CA, US
Neil Ashweek - San Diego CA, US
Assignee:

Neurocrine Biosciences, Inc. - San Diego CA
International Classification:

C07D 513/02
C07D 401/00
US Classification:

546114, 546122
Abstract:

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:.

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto
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US Patent:

8507536, Aug 13, 2013
Filed:

Aug 10, 2012
Appl. No.:

13/572510
Inventors:

Graham Beaton - Poway CA, US
Mi Chen - San Diego CA, US
Timothy Richard Coon - Carlsbad CA, US
Todd Ewing - San Diego CA, US
Wanlong Jiang - San Diego CA, US
Jinghua Yu - San Marcos CA, US
Willy Moree - San Diego CA, US
Warren Wade - San Diego CA, US
Liren Zhao - San Diego CA, US
Yun-fei Zhu - San Diego CA, US
Martin Rowbottom - San Diego CA, US
Neil Ashweek - San Diego CA, US
Assignee:

Neurocrine Biosciences, Inc. - San Diego CA
International Classification:

C07D 211/06
C07D 213/78
C07D 211/70
A61K 31/44
A61P 25/00
US Classification:

514344, 514352, 514357, 546286, 546304, 546334
Abstract:

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:.

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto
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US Patent:

20100152207, Jun 17, 2010
Filed:

Apr 4, 2008
Appl. No.:

12/594809
Inventors:

Graham Beaton - Poway CA, US
Mi Chen - San Diego CA, US
Timothy Richard Coon - Carlsbad CA, US
Todd Ewing - San Diego CA, US
Wanlong Jiang - San Diego CA, US
Willy Moree - San Diego CA, US
Martin Rowbottom - San Diego CA, US
Warren Wade - San Diego CA, US
Liren Zhao - San Diego CA, US
Richard Lowe - Oakland CA, US
Nicole Smith - San Diego CA, US
Neil Ashweek - San Diego CA, US
Yun-Fei Zhu - San Diego CA, US
International Classification:

A61K 31/519
C07D 213/56
A61K 31/4418
C07D 215/38
A61K 31/47
C07D 495/04
C07C 233/67
A61K 31/165
C07D 213/84
A61K 31/44
C07D 401/04
A61K 31/4439
C07D 213/62
C07D 239/02
A61K 31/505
C07D 401/12
C07D 413/12
C07D 403/02
A61K 31/444
A61P 15/00
US Classification:

5142601, 546337, 514357, 546175, 514311, 544278, 564174, 514622, 546286, 514344, 5462754, 514341, 546300, 514351, 544316, 514274, 5462684, 514340, 5462721, 546261, 514335
Abstract:

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

New Compounds, Pharmaceutical Compositions And Uses Thereof
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US Patent:

20130065906, Mar 14, 2013
Filed:

Mar 13, 2012
Appl. No.:

13/418376
Inventors:

Bernd NOSSE - Biberach an der Riss, DE
Andreas BLUM - Warthausen, DE
Steffen BREITFELDER - Attenweiler, DE
Armin HECKEL - Biberach an der Riss, DE
Frank HIMMELSBACH - Mittelbiberach, DE
Elke LANGKOPF - Biberach an der Riss, DE
Bernd WELLENZOHN - Langenargen, DE
Neil J. ASHWEEK - Escondido CA, US
Nicole HARRIOTT - San Diego CA, US
Assignee:

NEUROCRINE BIOSCIENCES, INC. - San Diego CA
BOEHRINGER INGELHEIM INTERNATIONAL GMBH - Ingelheim am Rhein
International Classification:

C07D 413/14
A61K 31/4545
C07D 417/14
A61K 31/506
A61P 3/06
A61K 31/497
A61K 31/501
C07D 401/14
A61P 3/10
A61P 3/04
A61K 31/454
C07D 413/04
US Classification:

51425203, 546209, 514326, 546194, 514318, 544331, 514275, 514321, 51425505, 544405, 544238, 544298, 514273, 546198
Abstract:

The present invention relates to compounds of general formula I,wherein the groups R, L, L, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

New Compounds, Pharmaceutical Compositions And Uses Thereof
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US Patent:

20130143892, Jun 6, 2013
Filed:

Jun 6, 2012
Appl. No.:

13/489557
Inventors:

Armin HECKEL - Biberach an der Riss, DE
Frank HIMMELSBACH - Mittelbiberach, DE
Elke LANGKOPF - Biberach an der Riss, DE
Bernd NOSSE - Biberach an der Riss, DE
Neil J. ASHWEEK - Escondido CA, US
Nicole HARRIOTT - San Diego CA, US
Assignee:

NEUROCRINE BIOSCIENCES, INC. - San Diego CA
BOEHRINGER INGELHEIM INTERNATIONAL GMBH - Ingelheim am Rhein
International Classification:

C07D 413/14
C07D 403/12
C07D 413/12
C07D 403/14
US Classification:

51425202, 544331, 514275, 544333, 514256, 544296, 546194, 514318, 544238, 546209, 514326, 544405, 51425505
Abstract:

The present invention relates to compounds of general formula I,wherein R, L, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto
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US Patent:

20140024665, Jan 23, 2014
Filed:

Jun 5, 2013
Appl. No.:

13/910961
Inventors:

Mi Chen - San Diego CA, US
Timothy Richard Coon - Carlsbad CA, US
Todd Ewing - San Diego CA, US
Wanlong Jiang - San Diego CA, US
Willy Moree - San Diego CA, US
Martin Rowbottom - San Diego CA, US
Warren Wade - San Diego CA, US
Liren Zhao - San Diego CA, US
Richard Lowe - Oakland CA, US
Nicole Smith - San Diego CA, US
Neil Ashweek - San Diego CA, US
Yun-Fei Zhu - San Diego CA, US
International Classification:

C07D 239/36
C07D 213/58
C07D 413/12
C07D 215/54
C07D 401/12
US Classification:

514274, 514311, 514335, 514340, 514341, 514343, 514344, 544316, 546165, 546261, 5462684, 5462721, 5462727, 5462764, 5462784, 5462791, 546286
Abstract:

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Resumes

Director, Research Chemistry

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Location:

San Diego, CA

Industry:

Biotechnology

Work:

Neurocrine Biosciences
Director, Research Chemistry
Neurocrine Biosciences
Principal Investigator
Neurocrine Biosciences Oct 2007 - Nov 2012
Scientist Ii
Neurocrine Biosciences Oct 2005 - Sep 2007
Scientist I
Neurocrine Biosciences Nov 2003 - Oct 2005
Postdoctoral Fellow

Education:

Nottingham University Business School 2002 - 2003
University of Exeter 1998 - 2001
Doctorates, Doctor of Philosophy, Chemistry University of Exeter 1994 - 1998

Skills:

Medicinal Chemistry
Drug Discovery
Drug Design
Organic Chemistry
Chemistry
Organic Synthesis
Drug Development
Gpcrs
Synthetic Chemistry
Parallel Synthesis
Heterocyclic Chemistry
Problem Solving
Nmr
Lc Ms
Lead Optimization

Interests:

New Technologies
Parallel Synthesis
Medicinal Chemistry
Organic Chemistry

Neil J Ashweek

Neil Ashweek Phones & Addresses

Work

Education

Skills

Interests

Industries

Us Patents

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto

Compounds, Pharmaceutical Composition And Methods Relating Thereto

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto

New Compounds, Pharmaceutical Compositions And Uses Thereof

New Compounds, Pharmaceutical Compositions And Uses Thereof

Gonadotropin-Releasing Hormone Receptor Antagonists And Methods Relating Thereto

Resumes

Director, Research Chemistry