Nazer K Khalaf

US Patent:

7998477, Aug 16, 2011

Filed:

Dec 19, 2003

Appl. No.:

10/741861

Inventors:

Kirill Yakovlevsky - Cambridge MA, US
Michael Shamashkin - Somerville MA, US
Nazer Khalaf - Worcester MA, US
Chandrika P. Govardhan - Lexington MA, US
Chu W. Jung - Arlington MA, US

Assignee:

Althea Technologies Inc. - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241301, 5303871, 530418, 977904

Abstract:

This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.

US Patent:

20020111311, Aug 15, 2002

Filed:

Dec 18, 2001

Appl. No.:

10/024405

Inventors:

Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US

International Classification:

A61K038/17
C07K007/64

US Classification:

514/012000, 530/359000, 530/317000, 514/009000

Abstract:

The invention provides the cyclic lipopeptide daptomycin and A-21978C analogs in crystalline form, methods of preparing the crystalline forms, compositions comprising the crystalline forms and methods of using these forms.

US Patent:

20030045484, Mar 6, 2003

Filed:

Dec 17, 2001

Appl. No.:

10/024701

Inventors:

Dennis Keith - Montclair NJ, US
Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US

International Classification:

C07H017/08
A61K031/7048

US Classification:

514/028000, 536/007100

Abstract:

The present invention relates to methods of providing crystalline and crystal-like forms of daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying daptomycin.

US Patent:

20030211127, Nov 13, 2003

Filed:

Jan 2, 2003

Appl. No.:

10/337061

Inventors:

Alexey Margolin - Newton MA, US
Rose Persichetti - Stow MA, US
Nancy St. Clair - Durham NC, US
Nazer Khalaf - Worcester MA, US
Bhami Shenoy - Woburn MA, US

International Classification:

A61K038/28
A61K038/19
A61K038/43
A61K039/395
A61K039/00
C12N009/14
C12N009/24
A61K039/02
C11D003/386

US Classification:

424/401000, 510/226000, 510/330000, 424/185100, 424/094100, 514/003000, 514/012000, 424/236100, 435/195000, 435/198000, 435/200000, 530/303000, 530/313000, 530/350000, 530/399000, 530/351000, 424/130100, 424/085100, 530/389100

Abstract:

The present invention relates to crosslinked protein crystals characterized by the ability to change from insoluble and stable form to soluble and active form upon a change in the environment of said crystals, said change being selected from the group consisting of change in temperature, change in pH, change in chemical composition, change from concentrate to dilute form, change in oxidation-reduction potential of the solution, change in the incident radiation, change in transition metal concentration, change in flouride concentration, change in free radical concentration, change in metal chelater concentration, change in shear force acting upon the crystals and combinations thereof. According to one embodiment of this invention, such crosslinked protein crystals are capable of releasing their protein activity at a controlled rate. This invention also provides methods for producing such crosslinked protein crystals, methods using them for protein delivery and methods using them in cleaning agents, including detergents, pharmaceutical compositions, vaccines, personal care compositions, including cosmetics, veterinary compositions, foods, feeds, diagnostics and formulations for decontamination.

US Patent:

20040202643, Oct 14, 2004

Filed:

Jan 16, 2004

Appl. No.:

10/760148

Inventors:

Alexey Margolin - Newton MA, US
Rose Persichetti - Stow MA, US
Nancy St. Clair - Durham NC, US
Nazer Khalaf - Worcester MA, US

Assignee:

Altus Biologics Inc.

International Classification:

A61K038/43
G06F019/00
G01N033/48
G01N033/50

US Classification:

424/094100, 702/019000

Abstract:

The present invention relates to crosslinked protein crystals characterized by the ability to change from insoluble and stable form to soluble and active form upon a change in the environment of said crystals, said change being selected from the group consisting of change in temperature, change in pH, change in chemical composition, change from concentrate to dilute form, change in shear force acting upon the crystals and combinations thereof. According to one embodiment of this invention, such crosslinked protein crystals are capable of releasing their protein activity at a controlled rate. This invention also provides methods for producing such crosslinked protein crystals, methods using them for protein delivery and methods using them in cleaning agents, including detergents, pharmaceutical compositions, vaccines, personal care compositions, including cosmetics, veterinary compositions, foods, feeds, diagnostics and formulations for decontamination.

US Patent:

20040209804, Oct 21, 2004

Filed:

Dec 31, 2003

Appl. No.:

10/749962

Inventors:

Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US
Benjamin Simeone - Lexington MA, US

International Classification:

A61K038/27
C07K014/61

US Classification:

514/012000, 530/399000

Abstract:

The present invention relates to stable, extended release crystals of human growth hormone or a human growth hormone derivative and compositions or formulations comprising such crystals. The invention further provides methods for producing those crystals and compositions. The invention further provides methods for treatment of an individual having disorders associated with human growth hormone deficiency or which are ameliorated by treatment with human growth hormone using those crystals and compositions or formulations.

US Patent:

20060008532, Jan 12, 2006

Filed:

Jun 28, 2005

Appl. No.:

11/169956

Inventors:

Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US

International Classification:

A61K 39/395
A61K 38/54
A61K 9/14
A61K 38/19
A61K 38/18
A61K 38/20
A61K 38/22

US Classification:

424489000, 424085100, 424085200, 424144100, 514012000, 424094200

Abstract:

The present invention relates to complexes of protein crystals and ionic polymers and compositions comprising such complexes. The invention further provides methods for producing these complexes and compositions. The invention further provides methods for treatment of an individual having a disease requiring or ameliorated by sustained release of protein-based therapies.

US Patent:

20060014674, Jan 19, 2006

Filed:

Apr 18, 2005

Appl. No.:

11/108380

Inventors:

Dennis Keith - Montclair NJ, US
Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US

International Classification:

A61K 38/12
C07K 7/64

US Classification:

514009000, 530317000

Abstract:

The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.