Naweed Muhammad

US Patent:

7771760, Aug 10, 2010

Filed:

Mar 31, 2006

Appl. No.:

11/394495

Inventors:

Gene Curtis Jamieson - Boulder Creek CA, US
Naweed Muhammad - Fremont CA, US
Keith R. Bley - Mountain View CA, US

Assignee:

NeurogesX, Inc. - San Carlos CA

International Classification:

A61K 36/81

US Classification:

424760

Abstract:

Oils of capsaicinoids and methods of making and using them are described. In some variations, the oils of capsaicinoids comprise at least 40% w/w capsaicinoid and a solvent capable of solubilizing the capsaicinoid, wherein the oil of capsaicinoid is substantially free of capsaicinoid crystals or capsaicinoid precipitates. In other variations, the oils of capsaicinoids consist essentially of at least 40% w/w capsaicinoid and a solvent capable of solubilizing the capsaicinoid. The solvent may be a semi-volatile solvent, a non-volatile solvent, or a volatile solvent, and the oil may comprise at least 50% w/w capsaicinoid, 60% w/w capsaicinoid, 70% w/w capsaicinoid, 80% w/w capsaicinoid, 90% w/w capsaicinoid, or 95% w/w capsaicinoid. The oil of capsaicinoid may also include a crystallization inhibitor.

US Patent:

7943166, May 17, 2011

Filed:

Apr 12, 2004

Appl. No.:

10/823426

Inventors:

Naweed Muhammad - Sacramento CA, US
Gene C. Jamieson - Boulder Creek CA, US
Keith R. Bley - Mountain View CA, US
Sanjay Chanda - South San Francisco CA, US

Assignee:

Neurogesx, Inc. - San Mateo CA

International Classification:

A61L 15/00
A61L 15/16

US Classification:

424445, 424443, 424446, 424447

Abstract:

Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

US Patent:

8263059, Sep 11, 2012

Filed:

Jul 6, 2010

Appl. No.:

12/830997

Inventors:

Arturo J. Angel - Santa Rosa CA, US
Larry W. Litle - Lee's Summit MO, US
Keith R. Bley - Mountain View CA, US
Allan L. Wilcox - Mountain View CA, US
Gene Curtis Jamieson - Boulder Creek CA, US
Naweed Muhammad - Fremont CA, US

Assignee:

NeurogesX, Inc. - San Mateo CA

International Classification:

A61K 31/74
A61K 8/00
A61K 8/02

US Classification:

424 7805, 424401, 514627, 510119

Abstract:

The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e. g. , a composition in which capsaicin is soluble.

US Patent:

8263093, Sep 11, 2012

Filed:

Apr 8, 2011

Appl. No.:

13/083306

Inventors:

Naweed Muhammad - Fremont CA, US
Gene Curtis Jamieson - Boulder Creek CA, US
Keith R. Bley - Mountain View CA, US
Sanjay Chanda - South San Francisco CA, US

Assignee:

NeurogesX, Inc. - San Mateo CA

International Classification:

A61K 9/08
A61K 9/10

US Classification:

424400, 424401

Abstract:

Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

US Patent:

8273390, Sep 25, 2012

Filed:

Apr 8, 2011

Appl. No.:

13/083294

Inventors:

Naweed Muhammad - Fremont CA, US
Gene Curtis Jamieson - Boulder Creek CA, US
Keith R. Bley - Mountain View CA, US
Sanjay Chanda - South San Francisco CA, US

Assignee:

NeurogesX, Inc. - San Mateo CA

International Classification:

A61K 9/08

US Classification:

424760, 424445, 424446

Abstract:

Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

US Patent:

20040126430, Jul 1, 2004

Filed:

Sep 5, 2003

Appl. No.:

10/655911

Inventors:

Arturo Angel - Santa Rosa CA, US
Larry Litle - Lee's Summit MO, US
Keith Bley - Mountain View CA, US
Allan Wilcox - Mountain View CA, US
Gene Jamieson - Boulder Creek CA, US
Naweed Muhammad - Sacramento CA, US

International Classification:

A61K031/16
A61K009/14
A61K035/78

US Classification:

424/487000, 514/625000, 424/760000

Abstract:

The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

US Patent:

20040180081, Sep 16, 2004

Filed:

Mar 26, 2004

Appl. No.:

10/810185

Inventors:

Arturo Angel - Santa Rosa CA, US
Larry Litle - Lee's Summit MO, US
Keith Bley - Mountain View CA, US
Allan Wilcox - Mountain View CA, US
Gene Jamieson - Boulder Creek CA, US
Naweed Muhammad - Sacramento CA, US

International Classification:

A61K031/16
A61K009/70

US Classification:

424/449000, 514/630000

Abstract:

The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

US Patent:

20060204561, Sep 14, 2006

Filed:

Feb 14, 2006

Appl. No.:

11/354349

Inventors:

Naweed Muhammad - Fremont CA, US
Gene Jamieson - Boulder Creek CA, US
Keith Bley - Mountain View CA, US

International Classification:

A61K 36/81
A61K 31/16
A61F 13/02

US Classification:

424448000, 424760000, 514630000

Abstract:

Described here are drug delivery devices including an occlusive backing layer and a drug depot containing a TRPV1 agonist and a non-hydrophilic solvent. The drug depot may take various forms, such as an adhesive polymeric matrix, liquid reservoir, or microreservoir droplets. Methods of making and using the drug delivery devices are also described.