Nariman B Mehta

US Patent:

40911004, May 23, 1978

Filed:

Sep 23, 1976

Appl. No.:

5/726007

Inventors:

Nariman Bomanshaw Mehta - Raleigh NC
Lawrence Edward Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07D29508
A61K 31495

US Classification:

424250

Abstract:

Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R. sup. 1 are the same or different and are each hydrogen or lower alkyl, or R and R. sup. 1 taken together are (CH. sub. 2). sub. X where X is 4 or 5, or NRR. sup. 1 is ##STR2## where Y is 3 or 4 and R. sup. 3 is hydrogen or lower alkyl, or NRR. sup. 1 is ##STR3## where R. sup. 2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

US Patent:

39975401, Dec 14, 1976

Filed:

Jul 21, 1975

Appl. No.:

5/597697

Inventors:

Nariman Bomanshaw Mehta - Raleigh NC
Lawrence Edward Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07D29518

US Classification:

260268C

Abstract:

Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R. sup. 1 are the same or different and are each hydrogen or lower alkyl, or R and R. sup. 1 taken together are (CH. sub. 2). sub. X where X is 4 or 5, or NRR. sup. 1 is ##STR2## where Y is 3 or 4 and R. sup. 3 is hydrogen or lower alkyl, or NRR. sup. 1 is ##STR3## where R. sup. 2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

US Patent:

57602247, Jun 2, 1998

Filed:

Mar 28, 1997

Appl. No.:

8/828935

Inventors:

Nariman Bomanshaw Mehta - Lady Lake FL
Grady Evan Boswell - Cary NC
James Leroy Kelley - Raleigh NC

Assignee:

Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

C07D26530
A61K 31535

US Classification:

544106

Abstract:

Novel morpholines of formula (I) and their salts, wherein R and R1 are each either hydrogen or fluorine and R2 is hydrogen or methyl. The compounds have a variety of uses in human medicine, in particular in the treatment of mental disorders such as depression. ##STR1##.

US Patent:

52160289, Jun 1, 1993

Filed:

Jul 3, 1991

Appl. No.:

7/725863

Inventors:

Nariman B. Mehta - Leesburg FL
Lawrence E. Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

A61K 31135

US Classification:

514653

Abstract:

A halogen-substituted diphenylsufide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism.

US Patent:

40618633, Dec 6, 1977

Filed:

Sep 24, 1976

Appl. No.:

5/726453

Inventors:

Nariman Bomanshaw Mehta - Raleigh NC
Lawrence Edward Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07C14941

US Classification:

560 18

Abstract:

Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R. sup. 1 are the same or different and are each hydrogen or lower alkyl, or R and R. sup. 1 taken together are (CH. sub. 2). sub. X where X is 4 or 5, or NRR. sup. 1 is ##STR2## where Y is 3 or 4 and R. sup. 3 is hydrogen or lower alkyl, or NRR. sup. 1 is ##STR3## where R. sup. 2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

US Patent:

40440141, Aug 23, 1977

Filed:

Sep 23, 1976

Appl. No.:

5/726049

Inventors:

Nariman Bomanshaw Mehta - Raleigh NC
Lawrence Edward Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

C07D29516

US Classification:

26029373

Abstract:

Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R. sup. 1 are the same or different and are each hydrogen or lower alkyl, or R and R. sup. 1 taken together are (CH. sub. 2). sub. X where X is 4 or 5, or NRR. sup. 1 is ##STR2## where Y is 3 or 4 and R. sup. 3 is hydrogen or lower alkyl, or NRR. sup. 1 is ##STR3## where R. sup. 2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

US Patent:

40566323, Nov 1, 1977

Filed:

Aug 20, 1976

Appl. No.:

5/716163

Inventors:

Nariman Bomanshaw Mehta - Raleigh NC
Lawrence Edward Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

A01N 920
A01N 924

US Classification:

424330

Abstract:

Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R. sup. 1 are the same or different and are each hydrogen or lower alkyl, or R and R. sup. 1 taken together are (CH. sub. 2). sub. X where X is 4 or 5, or NRR. sup. 1 is ##STR2## where Y is 3 or 4 and R. sup. 3 is hydrogen or lower alkyl, or NRR. sup. 1 is ##STR3## where R. sup. 2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

US Patent:

50950398, Mar 10, 1992

Filed:

Jun 5, 1990

Appl. No.:

7/533613

Inventors:

Nariman B. Mehta - Raleigh NC
Lawrence E. Brieaddy - Raleigh NC

Assignee:

Burroughs Wellcome Co. - Research Triangle Park NC

International Classification:

A61K 31135
C07C21101

US Classification:

514655

Abstract:

A halogen-substituted diphenylsulfide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism.