Naresh Chandra Bhavaraju

US Patent:

6793670, Sep 21, 2004

Filed:

Oct 10, 2003

Appl. No.:

10/683647

Inventors:

Ivan Osorio - Leawood KS 66209
Naresh C. Bhavaraju - Mission KS 66202

International Classification:

A61F 712

US Classification:

607113, 607 99

Abstract:

A multi-purpose electrode mechanism for detection and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and/or the stimulation means to initiate or terminate the cooling therapy and/or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose electrode mechanism.

US Patent:

6904390, Jun 7, 2005

Filed:

Apr 1, 2003

Appl. No.:

10/404850

Inventors:

Alexei V. Nikitin - Lawrence KS, US
Mark G. Frei - Lawrence KS, US
Naresh C. Bhavaraju - Lawrence KS, US
Ivan Osorio - Leawood KS, US
Ruslan Davidchack - Wigston, GB

Assignee:

Flint Hills Scientific, L.L.C. - Lawrence KS

International Classification:

G06F011/26

US Classification:

702188, 324521

Abstract:

A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

US Patent:

6934580, Aug 23, 2005

Filed:

Jul 18, 2003

Appl. No.:

10/622239

Inventors:

Ivan Osorio - Leawood KS, US
Naresh C. Bhavaraju - Lawrence KS, US

Assignee:

Flint Hills Scientific, L.L.C. - Lawrence KS

International Classification:

A61B005/04
A61N001/36

US Classification:

600545, 600544, 607 45, 607 62

Abstract:

A system of accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional stimulation thereof; second accessing means having a plurality of contact surfaces to operatively connect the control means to the brain of the subject to provide access thereto for the purposes of obtaining three-dimensional recordings of the brain electrical activity of the subject; and a waveform bank containing a plurality of stimulating waveforms. The control means is configured to operative apply a first at least one of the stimulating waveforms of the waveform bank to the brain of the subject through the first accessing means and to assess acceptability within defined limits, as determined by preset criteria, of the subject's response to the application of the at first least one of the stimulating waveforms.

US Patent:

7006859, Feb 28, 2006

Filed:

Jul 18, 2003

Appl. No.:

10/622238

Inventors:

Ivan Osorio - Leawood KS, US
Naresh C. Bhavaraju - Lawrence KS, US

Assignee:

Flint Hills Scientific, L.L.C. - Lawrence KS

International Classification:

A61B 5/042
A61N 1/05

US Classification:

600378, 607116

Abstract:

An electrode with three-dimensional capabilities for detection and control of brain state changes of a subject. The electrode includes a disk portion having an upper surface and a lower surface, and a shaft portion secured to and extending perpendicularly outwardly from the lower surface of the disk portion; the shaft portion having an outer surface. The disk portion and shaft portion may include one or more recording or stimulating contact surfaces structured to operatively interact with the brain of a subject. Insulating material isolates each of the recording or stimulating contact surfaces from each other. At least one conductor operatively and separately connect each of the recording or stimulating contact surfaces in communication with external apparatus. The disk portion and shaft portion are structured relative to each other to operatively provide support and anchoring for each other while providing three-dimensional capabilities for detection and control of brain state changes of a subject. Modified embodiments include insertible/retractable electrode wires, both contained in channels and sheathed in axially displaceable cannulae; activating mechanisms for inserting/retracting the electrode wires and/or cannulae; and multiple shaft portions.

US Patent:

7079977, Jul 18, 2006

Filed:

Oct 15, 2003

Appl. No.:

10/687566

Inventors:

Ivan Osorio - Leawood KS, US
Naresh C. Bhavaraju - Mission KS, US
Thomas E. Peters - Lawrence KS, US
Mark G. Frei - Lawrence KS, US
Jonathan C. Werder - Corcoran MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G04F 1/00
A61B 5/00
A61B 1/36

US Classification:

702176, 600509, 607 32, 607 45, 607 60, 702177, 702178

Abstract:

Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.

US Patent:

7188053, Mar 6, 2007

Filed:

Aug 4, 2004

Appl. No.:

10/911031

Inventors:

Alexei V. Nikitin - Lawrence KS, US
Mark G. Frei - Lawrence KS, US
Naresh C. Bhavaraju - Lenexa KS, US
Ivan Osorio - Leawood KS, US

Assignee:

Flint Hills Scientific, L.L.C. - Lawrence KS

International Classification:

G06F 19/00

US Classification:

702188, 324512

Abstract:

A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

US Patent:

7204833, Apr 17, 2007

Filed:

Aug 2, 2004

Appl. No.:

10/909488

Inventors:

Ivan Osorio - Leawood KS, US
Naresh C. Bhavaraju - Mission KS, US

Assignee:

Flint Hills Scientific LLC - Lawrence KS

International Classification:

A61B 18/02

US Classification:

606 22, 606 21, 607105

Abstract:

A multi-purpose device mechanism for sensing and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and/or the stimulation means to initiate or terminate the cooling therapy and/or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose device mechanism. A modified embodiment includes a least one spiral conduit and at least one return conduit for cycling coolant or refrigerant to and from the shaft portion and an external reservoir. Another modified embodiment includes pressurizing means for extending at least one extendable tube into brain tissue surrounding the shaft portion.

US Patent:

7282030, Oct 16, 2007

Filed:

Oct 15, 2003

Appl. No.:

10/687567

Inventors:

Mark G. Frei - Lawrence KS, US
Ivan Osorio - Leawood KS, US
Naresh C. Bhavaraju - Mission KS, US
David L. Carlson - Fridley MN, US
Jonathon E. Giftakis - Brooklyn Park MN, US
Nina M. Graves - Minnetonka MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61B 5/00
A61B 5/04

US Classification:

600300, 128920, 600544

Abstract:

Apparatus and method support a repetitive administration of a therapeutic treatment through a delivery unit during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data.