Christopher D. Batich - Gainesville FL, US Bradley Jay Willenberg - Gainesville FL, US Takashi Hamazaki - Gainesville FL, US Naohiro Terada - Gainesville FL, US
Assignee:
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
C12N 11/10 C12N 11/04 C12N 5/02
US Classification:
435178, 435182, 424 937
Abstract:
The present invention provides copper capillary alginate gels stabilized with barium, chitosan, its derivates, or a combination thereof. These stabilized gels are useful as scaffolds for containing, growing, or regenerating biological agents and cells for in vivo or in vitro use.
Naohiro Terada - Gainesville FL, US Takashi Hamazaki - Gainesville FL, US
International Classification:
C12Q001/00 G01N033/53 G01N033/567 C12N005/06
US Classification:
435/004000, 435/007200, 435/007210, 435/354000
Abstract:
A method for identifying a drug candidate for promoting tissue-specific differentiation of a stem cell includes the steps of: providing a library of test substances and an in vitro culture of stem cells divided into at least two subcultures; contacting one of the subcultures with the first test substance from the library and a second subculture with a second test substance from the library; culturing the subcultures under conditions that would promote tissue-specific differentiation of the stem cells if an agent that promoted tissue-specific differentiation was in contact with the stem cells; and analyzing the cells in the subcultures for increased tissue specific gene expression.
Ant4 Inhibitor Compounds And Methods Of Use Thereof
Naohiro Terada - Gainesville FL, US David A. Ostrov - Gainesville FL, US
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION - GAINESVILLE FL
International Classification:
A61K 31/121 A61P 15/16 A61P 35/00 G06G 7/48
US Classification:
514675, 703 11
Abstract:
The invention relates to methods for inducing male contraception and to methods of treating cell proliferation related disorders or diseases, such as cancer. The invention further relates to pharmaceutical compositions for inducing male contraception and for treating cell proliferation related disorders or diseases.
Method For Inhibiting Nucleoside And Nucleobase Transport In Mammalian Cells, And Method For Inhibition Of Dna Virus Replication
Erwin W. Gelfand - Englewood CO Naohiro Terada - Englewood CO
Assignee:
Otsuka Pharmaceutical Co., Ltd. - Tokyo
International Classification:
A61K 3147
US Classification:
514314
Abstract:
A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of DNA virus replication are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
Method For Inhibiting Virus Replication In Mammalian Cells Using Carbostyil Derivatives
Erwin W. Gelfand - Englewood CO Naohiro Terada - Englewood CO
Assignee:
Otsuka Pharmaceutical Co., Ltd. - Tokyo
International Classification:
A01N 4342
US Classification:
514314
Abstract:
A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of virus replication, and augmenting phosphorylation of nucleoside analogues, are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
Directed Differentiation Of Pluripotent Stem Cells By Bacterial Injection Of Talen Proteins
- Gainesville FL, US Naohiro Terada - Gainesville FL, US Fang Bai - Gainesville FL, US
Assignee:
University of Florida Research Foundation, Incorporated - Gainesville FL
International Classification:
C12N 9/22 C07K 14/21 C12N 15/78 C12N 5/077
Abstract:
In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides a genetically engineered bacterium that may be useful for delivery of proteins into mammalian cells. In some aspects, the disclosure relates to improved methods of bacterially-mediated protein delivery.