Methods for producing peptides resulting from the proteolytic processing of amyloid precursor protein (APP). The methods involve high-density plating of IMR-32 cells. IMR-32 cells produced by the methods of the present invention are useful for screening for modulators of peptides resulting from proteolytic processing of APP, e.g., A and sAPP.
Denise Wieseler, Joan Arens, Kristine Bonertz, Lana Schulte, Todd Becker, Neil Hans, Brenda Uhing, Debra Johnson, Lynette Uhing, Michelle Wieseler, Nick Hochstein