Merck Co., Inc. - Rahway NJ Banyu Pharmaceutical Co., Ltd. - Tokyo
International Classification:
C07D22120
US Classification:
514278, 544330, 544405, 546 18
Abstract:
Compounds of general structural formula I such as that shown in structural formula II are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
Merck Co., Inc. - Rahway NJ Banyu Pharmaceutical Co., Ltd. - Tokyo
International Classification:
C07D47110
US Classification:
514278, 546 15, 544230, 564168, 548411
Abstract:
Compounds of general structural formula I are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
Douglas MacNeil - Westfield NJ, US Lihu Yang - Edison NJ, US Nancy Morin - Cranford NJ, US Takehiro Fukami - Ibaraki, JP Akio Kanatani - Ibaraki, JP Takahiro Fukuroda - Ibaraki, JP Yasuyuki Ishii - Saitama, JP Masaki Ihara - Ibaraki, JP
International Classification:
C07D487/12 C07D471/12
US Classification:
544/230000, 546/015000, 546/016000
Abstract:
Compounds of general structural formula I such as that shown in structural formula II are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
Cameron M. Douglas - Piscataway NJ Gary L. Chrebet - Princeton NJ Joseph Clemas - Metuchen NJ Mohammed El-Sherbeini - Westfield NJ Forrest Foor - New York NY Jennifer Nielsen Kahn - East Brunswick NJ Rosemarie Kelly - Westfield NJ Jean A. Marrinan - Somerset NJ Nancy R. Morin - Cranford NJ Janet C. Onishi - Westfield NJ Stephen Authur Parent - Cranbury NJ Naasa M. Ramadan - Westfield NJ Elizabeth A. Register - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07H 2104 C12N 115 C12P 2102 C07K 14395
US Classification:
536 2374
Abstract:
DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.
Compounds of the general structural formula I ##STR1## are selective NPY Y5 receptor antagonists. The compounds and compositions of the present invention are useful in the treatment of obesity and complications associated therewith.
Compounds of general structural formula I such as that shown in structural formula II ##STR1## are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.