Nancy C Morin

Author:

Nancy R. Morin

ISBN #:

0195057139

Author:

Nancy R. Morin

ISBN #:

0195112466

US Patent:

6495559, Dec 17, 2002

Filed:

Jun 29, 2001

Appl. No.:

09/896940

Inventors:

Douglas J. MacNeil - Westfield NJ
Lihu Yang - Edison NJ
Nancy R. Morin - Cranford NJ
Takehiro Fukami - Ibaraki, JP
Akio Kanatani - Ibaraki, JP
Takahiro Fukuroda - Ibaraki, JP
Yasuyuki Ishii - Saitama, JP
Masaki Ihara - Ibaraki, JP

Assignee:

Merck Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D22120

US Classification:

514278, 544330, 544405, 546 18

Abstract:

Compounds of general structural formula I such as that shown in structural formula II are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.

US Patent:

6638942, Oct 28, 2003

Filed:

Aug 26, 2002

Appl. No.:

10/228250

Inventors:

Douglas J. MacNeil - Westfield NJ
Lihu Yang - Edison NJ
Nancy R. Morin - Cranford NJ
Takehiro Fukami - Ibaraki, JP
Akio Kanatani - Ibaraki, JP
Takahiro Fukuroda - Ibaraki, JP
Yasuyuki Ishii - Saitama, JP
Masaki Ihara - Ibaraki, JP

Assignee:

Merck Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D47110

US Classification:

514278, 546 15, 544230, 564168, 548411

Abstract:

Compounds of general structural formula I are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.

US Patent:

20040063942, Apr 1, 2004

Filed:

Jul 21, 2003

Appl. No.:

10/624414

Inventors:

Douglas MacNeil - Westfield NJ, US
Lihu Yang - Edison NJ, US
Nancy Morin - Cranford NJ, US
Takehiro Fukami - Ibaraki, JP
Akio Kanatani - Ibaraki, JP
Takahiro Fukuroda - Ibaraki, JP
Yasuyuki Ishii - Saitama, JP
Masaki Ihara - Ibaraki, JP

International Classification:

C07D487/12
C07D471/12

US Classification:

544/230000, 546/015000, 546/016000

Abstract:

Compounds of general structural formula I such as that shown in structural formula II are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.

US Patent:

58213538, Oct 13, 1998

Filed:

Aug 1, 1996

Appl. No.:

8/619554

Inventors:

Cameron M. Douglas - Piscataway NJ
Gary L. Chrebet - Princeton NJ
Joseph Clemas - Metuchen NJ
Mohammed El-Sherbeini - Westfield NJ
Forrest Foor - New York NY
Jennifer Nielsen Kahn - East Brunswick NJ
Rosemarie Kelly - Westfield NJ
Jean A. Marrinan - Somerset NJ
Nancy R. Morin - Cranford NJ
Janet C. Onishi - Westfield NJ
Stephen Authur Parent - Cranbury NJ
Naasa M. Ramadan - Westfield NJ
Elizabeth A. Register - Scotch Plains NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07H 2104
C12N 115
C12P 2102
C07K 14395

US Classification:

536 2374

Abstract:

DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.

US Patent:

44606893, Jul 17, 1984

Filed:

Mar 8, 1983

Appl. No.:

6/471394

Inventors:

Forrest Foor - New York NY
Nancy R. Morin - Cranford NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12N 1500
C12N 700
C12N 702
C12N 100
C12N 120
C12P 2100
C12R 1465

US Classification:

435172

Abstract:

Disclosed is the novel bacteriophage TG1, TG1 derivatives, and the corresponding genome or nucleic acid components of such bacteriophages and derivatives of such genome, which are useful as DNA cloning vectors into organisms, such as bacteria, for example, Streptomyces cattleya NRRL 8057; portions of such phage genome are additionally useful as adjuncts in recombinant DNA cloning procedures, for example: (1) to permit the maintenance of cloned DNA in the host, either in an integrated state or as an autonomous element; (2) to serve as promoters for increasing expression of endogenous or foreign genes wherein said promoters are ligated to such genes or otherwise serve as promoters; and (3) to serve as regulatory elements for achieving control over endogenous and foreign gene expression; as cloning vectors, TG1, its deletion mutants, and other derivatives serve for the amplification and transfer of DNA sequences (genes) coding for useful functions, for example, genes necessary for the production of the antibiotic thienamycin, or genes necessary for the production of hepatitis B antigen, and of DNA sequences which are useful per se, for example, distinct plasmid vectors which are inherently useful; such modified cloning vectors (hybrid DNA molecules comprising the TG1 genome or portions thereof and foreign DNA sequence) are introduced into the recipient organism by infection, transfection or transformation; wherein the hybrid DNA functions in an integrated mode, in a lytic (vegetative phase) mode and/or in a plasmid mode. Also disclosed are microorganisms comprising TG1 prophage and deletion and hybrid (chimeric) derivatives thereof; and microorganisms comprising hybrid (chimeric) phage-plasmids and derivatives thereof.

US Patent:

61911607, Feb 20, 2001

Filed:

Nov 8, 1999

Appl. No.:

9/436120

Inventors:

Douglas J. MacNeil - Westfield NJ
Lihu Yang - Edison NJ
Nancy R. Morin - Cranford NJ
Takehiro Fukami - Ibaraki, JP
Akio Kanatani - Ibaraki, JP
Takahiro Fukuroda - Ibaraki, JP
Yasuyuki Ishii - Saitama, JP
Masaki Ihara - Ibaraki, JP

Assignee:

Merck & Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd. - Tokyo

International Classification:

A61K 31495
A61K 3140
C07D23902
C07D20954
C07D27760

US Classification:

514409

Abstract:

Compounds of the general structural formula I ##STR1## are selective NPY Y5 receptor antagonists. The compounds and compositions of the present invention are useful in the treatment of obesity and complications associated therewith.

US Patent:

63132982, Nov 6, 2001

Filed:

Sep 7, 2000

Appl. No.:

9/656698

Inventors:

Lihu Yang - Edison NJ
Douglas J. MacNeil - Westfield NJ
Nancy R. Morin - Cranford NJ
Takehiro Fukami - Ibaraki, JP
Takahiro Fukuroda - Ibaraki, JP
Akio Kanatani - Ibaraki, JP
Yasuyuki Ishii - Saitama, JP
Masaki Ihara - Ibaraki, JP

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D47120
C07D47110
C07D22120
A61K 31438
A61K 31499

US Classification:

546 17

Abstract:

Compounds of general structural formula I such as that shown in structural formula II ##STR1## are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.