Murugappa V Vedachalam

US Patent:

6982346, Jan 3, 2006

Filed:

Jul 1, 2003

Appl. No.:

10/611095

Inventors:

Jon Kirk Smith - Marion MA, US
Zongzheng Liu - Fall River MA, US
Murugappa Vedachalam - Raynham MA, US
David Compton - Waquoit MA, US

Assignee:

ISP Investments Inc. - Wilmington DE

International Classification:

C07C 69/34
C07C 69/52
C07C 67/36

US Classification:

560190, 560196, 560198, 560204

Abstract:

A process of making D-panthenyl triacetate which includes reacting D-panthenol with acetic anhydride in the presence of the catalyst polymer bound dimethylaminopyridine to form an exothermic mixture. The so-produced acetic acid, and the catalyst are removed from the exothermic mixture which is then neutralized with sodium hydroxide. Sodium acetate in the form of a solid is removed by filtration. The D-panthenyl triacetate is useful in cosmetic compositions.

US Patent:

20130310594, Nov 21, 2013

Filed:

Jan 28, 2013

Appl. No.:

13/752361

Inventors:

John Gregory Reid - Groton MA, US
Murugappa Vedachalam - Raynham MA, US

Assignee:

OptMed, Inc. - New York NY

International Classification:

C07C 253/30
C07C 67/00

US Classification:

558443, 560190

Abstract:

An improvement in the production of 1,1-disubstituted ethylenes is attained by contacting a 1,1-disubstituted ethylene with alumina and separating the alumina to obtain a 1,1-disubstituted ethylene with a good combination of cost, purity, shelf life and cure rate.

US Patent:

6624307, Sep 23, 2003

Filed:

Mar 28, 2002

Appl. No.:

10/109434

Inventors:

Murugappa Vedachalam - Raynham MA
Jon Kirk Smith - Marion MA

Assignee:

ISP Investments Inc. - Wilmington DE

International Classification:

C07D21309

US Classification:

546250, 546290

Abstract:

Commercially viable process for producing 2,6-dihydroxy-3,4-dimethlpridine. The process includes reacting 2-cyanoacetamide with sodium methoxide followed by condensation with ethyl 2-methylacetoacetate in methanol to give the sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile. The sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile is hydrolyzed with hydrobromic acid and decarboxylated to the hydrobromide salt of 2,6-dihydroxy-3,4-dimethylpyridine. The desired 2,6-dihydroxy-3,4-dimethylpyridine is produced from the hydrobromide salt by neutralizing the same with sodium hydroxide.