Muneaki Kurimura

US Patent:

7399864, Jul 15, 2008

Filed:

Aug 1, 2002

Appl. No.:

10/208738

Inventors:

Shinji Aki - Tokushima, JP
Muneaki Kurimura - Rockville MD, US
Takao Nishi - Tokushima, JP
Junichi Minamikawa - Naruto, JP
Michiaki Tominaga - Tokushima, JP

Assignee:

Otsuka Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D 215/38

US Classification:

546158, 546157

Abstract:

The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.

US Patent:

7825251, Nov 2, 2010

Filed:

Aug 3, 2007

Appl. No.:

11/833592

Inventors:

Shinji Aki - Itano-gun, JP
Muneaki Kurimura - Rockville MD, US
Takao Nishi - Itano-gun, JP
Junichi Minamikawa - Naruto, JP
Michiaki Tominaga - Itano-gun, JP
Norihiro Fukuyama - Tokushima, JP
Akihiro Yamamoto - Tokushima, JP

Assignee:

Otsuka Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D 215/16

US Classification:

546157, 546158

Abstract:

The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.