Mordecai P Blaustein

US Patent:

56957564, Dec 9, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/466795

Inventors:

Mordecai P. Blaustein - Baltimore MD
John M. Hamlyn - Baltimore MD
Douglas W. Harris - Portage MI
James H. Ludens - Portage MI
William Rodney Mathews - Plainwell MI
Jed F. Fisher - Three Rivers MI
Frederic Mandel - Vicksburg MI
Donald W. DuCharme - Paw Paw MI

Assignee:

University of Maryland at Baltimore - Baltimore MD

International Classification:

A61K 39385
A61K 39395
C07K 1626
C07K 1702

US Classification:

4241301

Abstract:

Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.

US Patent:

51642964, Nov 17, 1992

Filed:

Aug 31, 1990

Appl. No.:

7/575714

Inventors:

Mordecai P. Blaustein - Baltimore MD
John M. Hamlyn - Baltimore MD
Douglas W. Harris - Portage MI
James H. Ludens - Portage MI
William R. Mathews - Plainwell MI
Jed F. Fisher - Three Rivers MI
Frederic Mandel - Vicksburg MI
Donald W. DuCharme - Paw Paw MI

Assignee:

University of Maryland at Baltimore - Baltimore MD

International Classification:

C12Q 100
G01N 3353

US Classification:

435 724

Abstract:

Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine call hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.

US Patent:

46650199, May 12, 1987

Filed:

Aug 31, 1983

Appl. No.:

6/528009

Inventors:

John M. Hamlyn - Baltimore MD
Mordecai P. Blaustein - Baltimore MD
A. Avinoam Kowarski - Baltimore MD

Assignee:

University of Maryland - Baltimore MD

International Classification:

C12Q 142
C12Q 134

US Classification:

435 21

Abstract:

A method for measuring plasma levels of an inhibitor of (Na. sup. + +K. sup. +)ATPase associated with hypertension comprising: (1) incubating deproteinized plasma of a patient suspected of being hypertensive in a (Na. sup. + +K. sup. +)ATPase assay solution comprising (a) (Na. sup. + +K. sup. +)ATPase; and (2) following the activity of the (Na. sup. + +K. sup. +)ATPase over the course of time, and use of the method in diagnosing hypertension and in monitoring anti-hypertensive therapy.

US Patent:

54299284, Jul 4, 1995

Filed:

Jul 28, 1992

Appl. No.:

7/921207

Inventors:

Mordecai P. Blaustein - Baltimore MD
John M. Hamlyn - Baltimore MD
Douglas W. Harris - Portage MI
James H. Ludens - Portage MI
William R. Mathews - Plainwell MI
Jed F. Fisher - Three Rivers MI
Frederic Mandel - Vicksburg MI
Donald W. DuCharme - Paw Paw MI

Assignee:

University of Maryland at Baltimore - Baltimore MD

International Classification:

G01N 3353
G01N 33555
G01N 33567

US Classification:

435 724

Abstract:

Methods using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject are disclosed.

US Patent:

58440917, Dec 1, 1998

Filed:

Jun 25, 1993

Appl. No.:

8/081693

Inventors:

Mordecai P. Blaustein - Baltimore MD
John M. Hamlyn - Baltimore MD
Douglas W. Harris - Portage MI
James H. Ludens - Portage MI
William Rodney Mathews - Plainwell MI
Jed F. Fisher - Three Rivers MI
Frederic Mandel - Vicksburg MI
Donald W. DuCharme - Paw Paw MI

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

C07K 1618
C07K 1447

US Classification:

5303871

Abstract:

Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.

Author:

Mordecai P. Blaustein

ISBN #:

0323013414

Author:

Mordecai P. Blaustein

ISBN #:

0890049599

Author:

Mordecai P. Blaustein

ISBN #:

0897666933

Author:

Mordecai P. Blaustein

ISBN #:

0897666941