Mitree M Ponpipom from Branchburg, NJ, age 85

Aliphatic Amine Substituted Piperidyl Diaryl Pyrrole Derivatives As Antiprotozoal Agents
view source
US Patent:

6432980, Aug 13, 2002
Filed:

Nov 10, 2000
Appl. No.:

09/710165
Inventors:

Tesfaye Biftu - Westfield NJ
Danqing D. Feng - Branchburg Township NJ
Mitree M. Ponpipom - Branchburg NJ
Xiaoxia Qian - New York NY
Narindar Girotra - Old Bridge NJ
Michael H. Fischer - Ringoes NJ
Matthew J. Wyvratt - Mountainside NJ
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 314523
US Classification:

514318, 546194, 546187, 544129, 544 96, 5142355, 5142288, 514316
Abstract:

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Aliphatic Hydroxy Substituted Piperidyl Diaryl Pyrrole Derivatives As Antiprotozoal Agents
view source
US Patent:

6528531, Mar 4, 2003
Filed:

Nov 10, 2000
Appl. No.:

09/709961
Inventors:

Danqing D. Feng - Branchburg Township NJ
Mitree M. Ponpipom - Branchburg NJ
Xiaoxia Qian - New York NY
Michael H. Fisher - Ringoes NJ
Matthew J. Wyvratt - Mountainside NJ
Robert L. Bugianesi - Brick NJ
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 31445
US Classification:

514318, 514326, 514327, 514352, 514354, 546194, 546208, 546210, 546223
Abstract:

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Diaryltriazoles As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase-1
view source
US Patent:

8178546, May 15, 2012
Filed:

Apr 14, 2010
Appl. No.:

12/759737
Inventors:

Susan D. Aster - Teaneck NJ, US
James M. Balkovec - Martinsville NJ, US
Donald W. Graham - Mountainside NJ, US
Xin Gu - Scotch Plains NJ, US
Nancy J. Kevin - East Brunswick NJ, US
Gool F. Patel - Califon NJ, US
Mitree Ponpipom - Branchburg NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07D 249/08
US Classification:

5142664
Abstract:

2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase Type 1 enzyme (11β-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11β-HSD-1.

Diaryltriazoles As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase-1
view source
US Patent:

20080255216, Oct 16, 2008
Filed:

Mar 25, 2005
Appl. No.:

10/593010
Inventors:

Susan D. Aster - Teaneck NJ, US
James M. Balkovec - Martinsville NJ, US
Donald W. Graham - Mountainside NJ, US
Xin Gu - Scotch Plains NJ, US
Nancy J. Kevin - East Brunswick NJ, US
Gool F. Patel - Califon NJ, US
Mitree Ponpipom - Branchburg NJ, US
International Classification:

A61K 31/4196
C07D 249/08
A61P 3/04
A61P 9/12
A61P 9/10
A61P 3/10
C07D 403/02
US Classification:

514383, 5482622, 5482664
Abstract:

2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase Type 1 enzyme (11&bgr;-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11&bgr;-HSD-1.

1-Substituted Glycopyranosides
view source
US Patent:

42282748, Oct 14, 1980
Filed:

Jul 10, 1978
Appl. No.:

5/922897
Inventors:

Mitree M. Ponpipom - North Plainfield NJ
Robert L. Bugianesi - Colonia NJ
Philippe L. Durette - New Providence NJ
Howard M. Katzen - North Plainfield NJ
Tsung-Ying Shen - Westfield NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07H 506
C07H 508
US Classification:

536 4
Abstract:

The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an. omega. -aminoalkylthio,. omega. -aminoalkyloxy or. omega. -aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These. omega. -amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.

Cholesterol-Lowering Agents
view source
US Patent:

53691253, Nov 29, 1994
Filed:

Mar 19, 1993
Appl. No.:

8/033913
Inventors:

Gregory D. Berger - Belle Mead NJ
James D. Bergstrom - Neshanic NJ
Tesfaye Biftu - Westfield NJ
Robert L. Bugianesi - Colonia NJ
Robert M. Burk - Laguna Beach CA
Narindar N. Girotra - Old Bridge NJ
C. H. Kuo - South Plainfield NJ
William H. Parsons - Edison NJ
Mitree M. Ponpipom - Branchburg NJ
Lori L. Whiting - West Carrollton OH
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 31335
C07D31904
US Classification:

514452
Abstract:

This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.

2,5-Diaryl Tetrahydrofurans And Analogs Thereof As Paf Antagonists
view source
US Patent:

49962035, Feb 26, 1991
Filed:

Jun 8, 1989
Appl. No.:

7/362915
Inventors:

Tesfaye Biftu - Parlin NJ
Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Soumya P. Sahoo - Edison NJ
Chan H. Kuo - South Plainfield NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D40512
C07D41312
A61K 3154
A61K 31495
US Classification:

5142315
Abstract:

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R. sup. 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.

Diaryl Piperidyl Pyrrole Derivatives As Antiprotozoal Agents
view source
US Patent:

62914804, Sep 18, 2001
Filed:

Nov 10, 2000
Appl. No.:

9/710147
Inventors:

Tesfaye Biftu - Westfield NJ
Danqing Dennis Feng - Branchburg Township NJ
Mitree M. Ponpipom - Branchburg NJ
Xiaoxia Qian - New York NY
Michael H. Fisher - Ringoes NJ
Matthew J. Wyvratt - Mountainside NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D40104
A61K 3144
US Classification:

514318
Abstract:

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Mitree M Ponpipom