Michael J Trainer

US Patent:

7471393, Dec 30, 2008

Filed:

Mar 7, 2005

Appl. No.:

10/598443

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 15/02

US Classification:

356336

Abstract:

An instrument for measuring the size distribution of a particle sample by counting and classifying particles into selected size ranges. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles at one time is reduced to an acceptable level. A light beam is focused or collimated through a sample cell, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle size. So both the decrease in the beam intensity, due to light removal by the particle, and increase of light, scattered by the particle, may be used to determine the particle size, to classify the particle and count it in a certain size range. If all of the particles pass through a single beam, then many small particles must be counted for each large one because typical distributions are uniform on a particle volume basis, and the number distribution is related to the volume distribution by the particle diameter cubed.

US Patent:

8634072, Jan 21, 2014

Filed:

May 21, 2010

Appl. No.:

12/784719

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 15/02
G01N 21/00

US Classification:

356335, 356336, 356341

Abstract:

An instrument for measuring characteristics of a particle sample by counting and classifying particles into selected ranges of particle characteristics. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles of interest at one time is reduced to an acceptable level. A light beam is projected through a sample space, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle characteristics. So both the decrease in the beam intensity, due to light removal by the particle, and light scattered by the particle, may be used to determine the particle characteristics, to classify the particle and count it in a certain range of particle characteristics.

US Patent:

20060094109, May 4, 2006

Filed:

Nov 2, 2004

Appl. No.:

10/979388

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

C12M 1/34
C12Q 1/04

US Classification:

435288700, 382133000, 435034000, 435808000

Abstract:

In patients with carcinomas tumor cells are shed into the blood, enumeration and characterization of these cells offers the opportunity to obtain a “real time” biopsy of the tumor and may improve the management of the disease. The frequency of circulating tumor cells is rare (

US Patent:

20070206203, Sep 6, 2007

Filed:

Apr 9, 2005

Appl. No.:

10/599737

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01B 9/02

US Classification:

356521000

Abstract:

An instrument for measuring the size and characteristics of a particle contained in a sample of particles. A particle sample is introduced into a sample chamber. The sample particles are subjected to centrifugal forces so that large particles travel in the sample chamber at velocities greater than small particles. Light is shown upon the particles as they travel in the sample chamber. The particles diffract the light. The diffracted light is then received by detectors that convert the diffracted light into corresponding electronic signals. The electronic signals are analyzed to determine the size and characteristics of the particles that caused the diffracted light.

US Patent:

20070242269, Oct 18, 2007

Filed:

Oct 4, 2006

Appl. No.:

11/538669

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 15/02

US Classification:

356336000

Abstract:

An instrument for measuring the size distribution of a particle sample by counting and classifying particles into selected size ranges. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles at one time is reduced to an acceptable level. A light beam is focused or collimated through a sample cell, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle size. So both the decrease in the beam intensity, due to light removal by the particle, and increase of light, scattered by the particle, may be used to determine the particle size, to classify the particle and count it in a certain size range. If all of the particles pass through a single beam, then many small particles must be counted for each large one because typical distributions are uniform on a particle volume basis, and the number distribution is related to the volume distribution by the particle diameter cubed.

US Patent:

20080204716, Aug 28, 2008

Filed:

Oct 25, 2007

Appl. No.:

11/923894

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 21/00

US Classification:

356 73, 356338, 356343

Abstract:

An instrument for measuring the size distribution of a particle sample by counting and classifying particles into selected size ranges. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles at one time is reduced to an acceptable level. A light beam is focused or collimated through a sample cell, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle size. So both the decrease in the beam intensity, due to light removal by the particle, and increase of light, scattered by the particle, may be used to determine the particle size, to classify the particle and count it in a certain size range. If all of the particles pass through a single beam, then many small particles must be counted for each large one because typical distributions are uniform on a particle volume basis, and the number distribution is related to the volume distribution by the particle diameter cubed.

US Patent:

20080204717, Aug 28, 2008

Filed:

Oct 25, 2007

Appl. No.:

11/924247

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 21/00
G06F 19/00
G06F 17/16

US Classification:

356 73, 702 70, 708520

Abstract:

An instrument for measuring the size distribution of a particle sample by counting and classifying particles into selected size ranges. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles at one time is reduced to an acceptable level. A light beam is focused or collimated through a sample cell, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle size. So both the decrease in the beam intensity, due to light removal by the particle, and increase of light, scattered by the particle, may be used to determine the particle size, to classify the particle and count it in a certain size range. If all of the particles pass through a single beam, then many small particles must be counted for each large one because typical distributions are uniform on a particle volume basis, and the number distribution is related to the volume distribution by the particle diameter cubed.

US Patent:

20080204718, Aug 28, 2008

Filed:

Oct 26, 2007

Appl. No.:

11/924660

Inventors:

Michael Trainer - Coopersburg PA, US

International Classification:

G01N 21/00

US Classification:

356 73

Abstract:

An instrument for measuring the size distribution of a particle sample by counting and classifying particles into selected size ranges. The particle concentration is reduced to the level where the probability of measuring scattering from multiple particles at one time is reduced to an acceptable level. A light beam is focused or collimated through a sample cell, through which the particles flow. As each particle passes through the beam, it scatters, absorbs, and transmits different amounts of the light, depending upon the particle size. So both the decrease in the beam intensity, due to light removal by the particle, and increase of light, scattered by the particle, may be used to determine the particle size, to classify the particle and count it in a certain size range. If all of the particles pass through a single beam, then many small particles must be counted for each large one because typical distributions are uniform on a particle volume basis, and the number distribution is related to the volume distribution by the particle diameter cubed.