Michael S Seidel

Author:

Michael Seidel

ISBN #:

0140121048

Author:

Michael Seidel

ISBN #:

0231078587

Author:

Michael Seidel

ISBN #:

0231102984

Author:

Michael Seidel

ISBN #:

0300020287

Author:

Michael Seidel

ISBN #:

0300021127

Author:

Michael Seidel

ISBN #:

0300034989

Author:

Michael Seidel

ISBN #:

0404635385

Author:

Michael Seidel

ISBN #:

0404635393

US Patent:

6342619, Jan 29, 2002

Filed:

Dec 7, 2000

Appl. No.:

09/731955

Inventors:

Michael C. Seidel - Chalfont PA 18914

International Classification:

C11C 300

US Classification:

554126

Abstract:

A synthesis process is disclosed for producing a conjugated fatty acid at specified temperature in high yield, including providing an ester of a fatty acid having somewhere in its carbon chain a chain of four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, and a double bond is positioned between carbon three and carbon four and reacting with a chloride selected from the group consisting of toluenesulfonyl chloride, methanesulfonyl chloride, benzenesulfonyl chloride, alkylsulfonyl chloride, and arylsulfonyl chloride at a temperature in the range of 10Â C. -100Â C. , preferably 20Â C. -50Â C. The synthesis process provides a conjugated fatty acid formed from the ester reacted with diazabicycloundecene. In one aspect, the ester is formed in a pyridine solvent. In one aspect, a mesylate is formed with mesyl chloride in acetonitrile and triethyl amine.

US Patent:

6410763, Jun 25, 2002

Filed:

Nov 24, 2000

Appl. No.:

09/721849

Inventors:

Michael C. Seidel - Chalfont PA 18914

International Classification:

C11B 700

US Classification:

554193, 554191

Abstract:

A method for providing a purified conjugated fatty acid is disclosed. The purified conjugated fatty acid is formed by separating by liquid chromatography a conjugated fatty acid formed by a novel synthesis of reacting an ester of a fatty acid having a four carbon chain such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, and a double bond is positioned between carbon three and carbon four, with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of said ester, and reacting the tosylate or mesylate of said ester with diazabicyclo-undecene. Reacting an ester of a fatty acid having a four carbon chain such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, a double bond is positioned between carbon three and carbon four, with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of said ester, and reacting the tosylate or mesylate of said ester with diazabicyclo-undecene forms a conjugated fatty acid having a purity greater than 50%, and separating by liquid chromatography forms a conjugated fatty acid having a purity greater than 90%. In one aspect, the liquid chromatography uses a strong acid macroreticular ion exchange resin. In one aspect, the liquid chromatography includes silver ion liquid chromatography.

US Patent:

6602908, Aug 5, 2003

Filed:

Mar 30, 2001

Appl. No.:

09/823334

Inventors:

Michael C. Seidel - Chalfont PA 18914

International Classification:

A01N 3702

US Classification:

514547, 554126

Abstract:

Treatment of carcinoma in a human is disclosed, including administering a therapeutically effective amount of a fatty acid having four carbons with two conjugated double bonds formed by reacting an ester of a fatty acid with a tosyl chloride or a mesyl chloride, the fatty acid having four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four. The tosylate or mesylate of the ester of the fatty acid having the chain of four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four is reacted with diazabicyclo-undecene. The method includes administering to a human a highly purified fatty acid in accordance with the present invention.

US Patent:

58920749, Apr 6, 1999

Filed:

Feb 18, 1997

Appl. No.:

8/800567

Inventors:

Michael C. Seidel - Chalfont PA

International Classification:

C07C 51347

US Classification:

554126

Abstract:

A synthesis process for producing 9-cis, 11-trans octadecadienoic acid at room temperature in high yield is disclosed, including providing a tosylate or mesylate of a methyl ester of ricinoleic acid and 9-cis, 11-trans octadecadienoic acid formed when the tosylate or mesylate reacts with diazabicyclo-undecene. In one aspect, the tosylate of the methyl ester of ricinoleic acid is formed with tosyl chloride in a pyridine solvent. In one aspect, the mesylate of the methyl ester of ricinoleic acid is formed with mesyl chloride in acetonitrile and triethyl amine. In one aspect, the tosylate or mesylate is reacted with diazabicyclo-undecene in a polar, non-hydoxylic solvent of acetonitrile to form the preferred isomer of 9-cis, 11-trans octadecadienoic acid at room temperature in high yield.

US Patent:

39624200, Jun 8, 1976

Filed:

Jul 3, 1974

Appl. No.:

5/485476

Inventors:

Michael C. Seidel - Chalfont PA
Evan H. Crook - Cherry Hill NJ

Assignee:

Rohm and Haas Company - Philadelphia PA

International Classification:

A61K 3178

US Classification:

424 81

Abstract:

Macroreticular resins have shown biological activity for gallstone removal and lowering serum cholesterol by selective adsorption of cholesterol from the bile.

US Patent:

61537748, Nov 28, 2000

Filed:

Apr 1, 1999

Appl. No.:

9/283504

Inventors:

Michael C. Seidel - Chalfont PA

International Classification:

C11B 700

US Classification:

554193

Abstract:

A method for providing a purified conjugated linoleic acid (CLA) is disclosed. The purified conjugated linoleic acid (CLA) is formed by separating by liquid chromatography a 9-cis, 11-trans octadecadienoic acid formed by a novel synthesis of reacting an ester of ricinoleic acid with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of an ester of ricinoleic acid, and reacting the tosylate or mesylate of an ester of ricinoleic acid with diazabicyclo-undecene. Reacting an ester of ricinoleic acid with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of an ester of ricinoleic acid, and reacting the tosylate or mesylate of an ester of ricinoleic acid with diazabicyclo-undecene forms a 9-cis, 11-trans octadecadienoic acid having a purity greater than 50%, and separating by liquid chromatography forms a 9-cis, 11-trans octadecadienoic acid having a purity greater than 90%. In one aspect, the liquid chromatography uses a strong acid macroreticular ion exchange resin. In one aspect, the liquid chromatography includes silver ion liquid chromatography.

US Patent:

41983963, Apr 15, 1980

Filed:

Dec 10, 1975

Appl. No.:

5/639335

Inventors:

Michael C. Seidel - Chalfont PA
Evan H. Crook - Cherry Hill NJ

Assignee:

Warren-Teed Laboratories, Inc. - Columbus OH

International Classification:

A61K 3174
A61K 3178

US Classification:

424 81

Abstract:

Macroreticular resins have shown biological activity for gallstone removal and lowering serum cholesterol by selective adsorption of cholesterol from the bile.

US Patent:

42713080, Jun 2, 1981

Filed:

Jun 14, 1979

Appl. No.:

6/048426

Inventors:

Michael C. Seidel - Chalfont PA
William C. von Meyer - Charlotte NC
Stanley A. Greenfield - Ambler PA

Assignee:

Rohm and Haas Company - Philadelphia PA

International Classification:

A01N 4364
C07D24908

US Classification:

548262

Abstract:

Substituted 1,2,4-4H-triazoles of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen atoms and R. sup. 3 is alkyl, alkenyl, alkynyl, cycloalkyl benzyl or phenyl. These compounds are fungicides and are particularly useful for the control of cereal rust.