Michael P Leveille

US Patent:

6423249, Jul 23, 2002

Filed:

Jun 22, 2000

Appl. No.:

09/599231

Inventors:

Michael J. Leveille - Northbridge MA

Assignee:

Waters Investments Limited

International Classification:

F21V 904

US Classification:

252588, 252584, 359350, 359361, 356 51, 356234

Abstract:

The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica glass monolith with a rare-earth dopant therein. The rare-earth dopant exhibits at least one spectral feature in at least the far UV range. The constituents of the gel-sol silica glass monolith are selected so the rare-earth doped sol-gel glass monolith exhibits a transmittance in the far UV range so each distinct spectral feature of the rare-earth dopant in the far UV range is discernable.

US Patent:

6452673, Sep 17, 2002

Filed:

Nov 7, 2000

Appl. No.:

09/707786

Inventors:

Michael J. Leveille - Northbridge MA
Joseph M. DeLuca - Mendon MA
Charles T. Murphy - North Attleboro MA
Robert J. Karol - Marlboro MA

Assignee:

Waters Investments Limited

International Classification:

G01N 410

US Classification:

356246, 356244, 356213, 738655, 7385433

Abstract:

A chromatographic flow cell having the capacity to handle fluid flow from one or more chromatographic systems, at widely varying flow rates without the need to change flow cells or detectors. The flow cell itself acts as a tee where two or more fluidic inlet lines intersect with a common inlet channel. The common inlet channel is configured so that the diameter and length minimizes the total volume, unswept volume, bandspreading, and backpressure. The common outlet channel, inlet lines and the outlet line are sized to provide for adequate fluidic handling at the varied flow rates.

US Patent:

6747740, Jun 8, 2004

Filed:

Oct 31, 2000

Appl. No.:

09/702513

Inventors:

Michael J. Leveille - Northbridge MA
Joseph M. DeLuca - Mendon MA

Assignee:

Waters Investments Limited

International Classification:

G01N 2105

US Classification:

356446, 356246

Abstract:

A photometric measurement flow cell having measurement path-lengths that can be adjusted down to less than 0. 1 mm. The measurement path-length is controlled by both a common flow cell body and the dimensional parameters of a stepped sealing optical element. The stepped optical element includes a stem portion that can be made in various lengths to create a family flow cell measurement path-lengths. The replacement of one stepped element with another having a different stem length within the flow cell creates a reliable method to adjust the measured path-length of the flow cell.

US Patent:

6783705, Aug 31, 2004

Filed:

Apr 11, 1997

Appl. No.:

08/834061

Inventors:

Michael J. Leveille - Northbridge MA

Assignee:

Waters Investments Limited

International Classification:

F21V 904

US Classification:

252588, 252584, 252589, 359350, 359361, 356 51, 356234, 250372, 250373

Abstract:

The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica glass monolith with a rare-earth dopant therein. The rare-earth dopant exhibits at least one spectral feature in at least the far UV range. The constituents of the gel-sol silica glass monolith are selected so the rare-earth doped sol-gel glass monolith exhibits a transmittance in the far UV range so each distinct spectral feature of the rare-earth dopant in the far UV range is discernable. The transmittance in a particular embodiment is at least about 50% at about 250 nm. The rare earth materials selected for use as dopants are those exhibiting a wide range of spectral features, preferably over a range from about 190 nm to about 700 nm and more particularly exhibit at least one distinct spectral feature in the range from about 190 nm to about 300 nm. In a specific embodiment, the rare-earth dopant includes atoms of erbium, having spectral features in a range from about 190 nm to about 650 nm and a distinguishable far UV spectral feature at about 257 nm.

US Patent:

20020096667, Jul 25, 2002

Filed:

Mar 19, 2002

Appl. No.:

10/101021

Inventors:

Michael Leveille - Northbridge MA, US

International Classification:

G02B005/22

US Classification:

252/588000

Abstract:

The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica glass monolith with a rare-earth dopant therein. The rare-earth dopant exhibits at least one spectral feature in at least the far UV range. The constituents of the gel-sol silica glass monolith are selected so the rare-earth doped sol-gel glass monolith exhibits a transmittance in the far UV range so each distinct spectral feature of the rare-earth dopant in the far UV range is discernable. The transmittance in a particular embodiment is at least about 50% at about 250 nm. The rare earth materials selected for use as dopants are those exhibiting a wide range of spectral features, preferably over a range from about 190 nm to about 700 nm and more particularly exhibit at least one distinct spectral feature in the range from about 190 nm to about 300 nm. In a specific embodiment, the rare-earth dopant includes atoms of erbium, having spectral features in a range from about 190 nm to about 650 nm and a distinguishable far UV spectral feature at about 257 nm.

US Patent:

20050156146, Jul 21, 2005

Filed:

Nov 3, 2004

Appl. No.:

10/980218

Inventors:

Michael Leveille - Northbridge MA, US

International Classification:

G01C025/00

US Classification:

252521100, 356006000, 428409000

Abstract:

The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica glass monolith with a rare-earth dopant therein. The rare-earth dopant exhibits at least one spectral feature in at least the far UV range. The constituents of the gel-sol silica glass monolith are selected so the rare-earth doped sol-gel glass monolith exhibits a transmittance in the far UV range so each distinct spectral feature of the rare-earth dopant in the far UV range is discernable. In a specific embodiment, the rare-earth dopant includes atoms of erbium, having spectral features in a range from about 190 nm to about 650 nm and a distinguishable far UV spectral feature at about 257 nm.

US Patent:

20110141465, Jun 16, 2011

Filed:

May 20, 2009

Appl. No.:

12/991765

Inventors:

Anthony Jeannotte - foxborough MA, US
Michael J. Leveille - Northbridge MA, US
Frank Denecke - Mendon MA, US

Assignee:

WATERS TECHNOLOGIES CORPORATION - Milford MA

International Classification:

G01N 1/10

US Classification:

356246

Abstract:

A flow cell for a photometric device includes a module having a body with a distal face defining an annular channel. The body also defines an axial central passage and an axial flow channel. A second module has a body with a proximal face defining an annular channel. The second body also defines an axial flow channel in fluid communication with the first axial flow channel. A light guiding member is within the central passage for exposing a fluid in the flow channels of the modules. An assembly seals an interface between the distal and proximal faces such that the fluid does not leak from the flow channels. The assembly has a metal gasket between the distal and proximal faces, the metal gasket defining a flow path between the flow channels, a first sealing member in the first annular channel and a second sealing member in the second annular channel.

US Patent:

58837213, Mar 16, 1999

Filed:

Jul 11, 1997

Appl. No.:

8/893823

Inventors:

Anthony C. Gilby - Foxborough MA
Michael J. Leveille - Northbridge MA
Joseph M. DeLuca - Mendon MA

Assignee:

Waters Investments Limited - New Castle DE

International Classification:

G01N 2105

US Classification:

356440

Abstract:

Embodiments of the present invention feature devices and methods for analyzing the absorbance spectra of a sample, and a method of making such device. The device comprises a housing having an exterior surface and an interior surface. The interior surface defines a chamber having an input opening and an exit opening defined by rims. The input opening has a first geometric shape and the exit opening has a second geometric shape. Any point about the rim at the input end can be connected by a straight line to any point on the rim of the exit end. The interior surface end of the chamber corresponds to the sum of these lines from the rim of the input opening, to the rim of the exit opening.