Michael B Gorin

Author:

Michael L. Gorin

ISBN #:

0788140876

US Patent:

20070191908, Aug 16, 2007

Filed:

Feb 15, 2007

Appl. No.:

11/675364

Inventors:

Doreen Jacob - Pittsburgh PA, US
Susan Stepko - Gibsonia PA, US
Steven Hackworth - Pittsburgh PA, US
Michael Lovell - Wexford PA, US
Marlin Mickle - Pittsburgh PA, US
Michael Gorin - Los Angeles CA, US

International Classification:

A61N 1/18

US Classification:

607048000

Abstract:

A method of stimulating a subject having a denervated muscle and a corresponding functional muscle that are responsible for producing actions, such as blinking, on first and second portions, respectively, of the subject's body. The method includes determining whether the functional muscle has contracted, generating a contraction signal if it is determined that it has contracted, and causing the denervated muscle to contract following the generation of the contraction signal. Also, an apparatus for stimulating such a subject including one or more sensing devices operatively associated with the functional muscle and one or more stimulating devices operatively associated with the denervated muscle. One or more of the sensing devices generates one or more first signals in response to activity indicating functional muscle contraction. The one or more stimulating devices are made to cause the denervated muscle to contract in response to the generation of the first signals.

US Patent:

20100273738, Oct 28, 2010

Filed:

Apr 22, 2010

Appl. No.:

12/765678

Inventors:

CHRISTIAN P. VALCKE - Orlinda CA, US
Michael Gorin - Los Altos CA, US
James E. Gharib - San Diego CA, US

International Classification:

C12Q 1/56
G01N 33/00
A61K 31/727

US Classification:

514 56, 422 681, 422 63, 435 13

Abstract:

An integrated patient monitoring and control system is provided which includes a closed-loop control system for monitoring and adjusting the heparin infusion rate for a patient. The system includes a processor which uses a dynamic patient model that is continuously adjusted based on the patient's aPTT measurements to calculate an optimal heparin infusion rate to achieve an operator-input aPTT target range. The processor also includes a forecasting model to calculate the optimum sample time interval for measuring the patient's aPTT to calculate a new infusion rate. An automated sampling system, which includes a storage device for storing a series of assay devices, an advancement mechanism for moving the assay devices to a sample area, and a measurement device for analyzing a sample dispensed on the assay, is provided. The sampling system is used to repeatedly measure the patient's aPTT according to the sample time interval determined by the processor.

US Patent:

52308669, Jul 27, 1993

Filed:

Mar 1, 1991

Appl. No.:

7/663217

Inventors:

Robert Shartle - Livermore CA
Donald Besemer - Los Altos Hills CA
Michael Gorin - Los Altos CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

B01L 1100
G01N 2100

US Classification:

422103

Abstract:

A capillary stop-flow junction located in a housing at an end of a capillary passageway used to transport a liquid and at the beginning of a non-capillary internal chamber in the housing, in which the stop-flow junction contains an improvement which comprises 1) means for selectively trapping a gas in the capillary passageway and non-capillary chamber, wherein when the means for trapping is activated and the liquid enters the capillary passageway, the gas is compressed by the liquid as the liquid flows through the capillary channel and stops flowing at the stop-flow junction; or 2) a stop-flow nozzle surrounding the capillary passageway and projecting into the chamber; or 3) the stop-flow junction being formed from a single housing body member; or 4) a rupture junction in the capillary pathway, wherein the rupture junction is a stop-flow junction providing less maximum available back pressure than the capillary stop-flow junction. Diluters capable of serial dilution that use the stop-flow junctions of the invention are also described.

US Patent:

50396170, Aug 13, 1991

Filed:

Apr 20, 1989

Appl. No.:

7/341045

Inventors:

Katheryne M. McDonald - Mountain View CA
Laura J. Winfrey - Belmont CA
Michael M. Gorin - Palo Alto CA
James L. Hill - San Jose CA
Po C. Hsu - Cupertino CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

G01N 3386

US Classification:

436 69

Abstract:

Methods and devices are provided for carrying out activated partial thromboplastin time (APTT) analysis on a whole blood sample to which no anticoagulant has been added by applying the sample to a capillary track contained in a housing, wherein the capillary track comprises sample entry and venting ports, at least one capillary track connecting the entry and venting ports, and reagents capable of initiating an APTT analysis, wherein clotting time is measured by the cessation of blood flow in the capillary track.

US Patent:

51048132, Apr 14, 1992

Filed:

Apr 13, 1989

Appl. No.:

7/337286

Inventors:

Don Besemer - Los Altos Hills CA
Michael Gorin - Palo Alto CA
Ian Gibbons - Menlo Park CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

G01N 2100
G01N 110

US Classification:

436179

Abstract:

A dilution and mixing cartridge is provided that allows single (or multiple) dilutions of a sample with a diluent in a disposable cartridge in which a measurement, such as optical density, is made. Addition of sample to the device automatically measures the sample, and addition of diluent automatically causes a fixed ratio of sample and diluent to enter a receiving chamber, in which mixing and measurement can take place. A number of preferred embodiments are provided in which the diluent application site is located at a vertical height below the sample application site, flow directing chambers are provided to control flow of desired volumes of sample or diluted sample at the appropriate locations in the device and to direct excess sample and diluent to waste locations, or control mechanism are provided at flow directing chambers and other internal locations to verify correct operation of the device.

US Patent:

50770179, Dec 31, 1991

Filed:

Nov 5, 1987

Appl. No.:

7/117791

Inventors:

Michael M. Gorin - Palo Alto CA
Robert S. Hillman - San Carlos CA
Ian Gibbons - Menlo Park CA
Michael E. Cobb - Sunnyvale CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

B01L 300

US Classification:

422100

Abstract:

A dilution and mixing cartridge comprising a sample application site, a mixing chamber in fluid receiving relationship to the sample application site, a diluent application site in fluid donating relationship to the mixing chamber, a first valve means selectively preventing flow from the diluent application site to the mixing chamber, and a mixture isolating chamber hydrostatically connected to the mixing chamber is provided along with a method for using this cartridge to sequentially dilute a sample with the same or different diluents.