Michael R Dunlavey

US Patent:

6985846, Jan 10, 2006

Filed:

Mar 30, 2001

Appl. No.:

09/823213

Inventors:

Michael R. Dunlavey - Needham MA, US

Assignee:

Pharsight Corporation - Mountain View CA

International Classification:

G06F 9/45

US Classification:

703 22, 705 2, 717136

Abstract:

A system and method for simulating clinical trial protocols with compiled state machines is presented. The system receives input data representing a clinical trial protocol. This information is sorted into a plurality of schedules, including dosage schedules, observation schedules, and various other types of schedules. The schedules are translated into a general purpose high level programming language and then compiled into and executable file. The executable file may comprise a plurality of discrete state machines, each state machine corresponding directly to a single schedule. During the clinical trial simulation, the executable file is run by the trial simulator to simulate the trial protocol.

US Patent:

7043415, May 9, 2006

Filed:

Mar 30, 2001

Appl. No.:

09/823214

Inventors:

Michael Robert Dunlavey - Needham MA, US
David J. Hermann - Chelsea MI, US
Jeffrey Alan Wald - Cary NC, US
Daniel Lee Weiner - Apex NC, US

Assignee:

Pharsight Corporation - Mountain View CA

International Classification:

G06G 7/48

US Classification:

703 12, 703 2, 715747, 715763, 715765, 702 19, 707 13

Abstract:

A method for interactively constructing pharmacological computational models is disclosed. A graphical user interface is presented through which a user may place and connect objects representing pharmacokinetic and pharmacodynamic elements. As the objects are placed and connected, they are converted into an internal format representing the statements of the corresponding computational model. These statements are actively presented to the user in a summarized form, as the computational model is constructed, to enable immediate verification of the model. This summarized form may be a surface syntax showing key equations that make up the model, or they may be graphs of behavior of one or more user-selected variables.

US Patent:

20080134140, Jun 5, 2008

Filed:

Oct 15, 2007

Appl. No.:

11/872369

Inventors:

Daniel L. Weiner - Apex NC, US
Michael Robert Dunlavey - Needham MA, US
Daniel Xavier Gilroy - Durham NC, US
Robert Hemstreet Leary - Cary NC, US
Jason Todd Chittenden - Raleigh NC, US

Assignee:

Pharsight Corporation - Mountain View CA

International Classification:

G06F 9/44

US Classification:

717105

Abstract:

Embodiments in accordance with the present invention relate to a platform facilitating different drug development software programs. In one embodiment, the integrated software platform includes a graphical environment for creating, storing, and manipulating workflows. The workflows depict operations that are to be performed by certain functional objects, and the flow of information between those objects. One example of an object is a model of drug behavior, disposition, and/or physiological response to drug activity, and certain embodiments allow for the graphical creation and editing of such a model. Other embodiments provide a user with the ability to easily overlay model predicted valves with observed data.

US Patent:

6937257, Aug 30, 2005

Filed:

Mar 30, 2001

Appl. No.:

09/823439

Inventors:

Michael R. Dunlavey - Needham MA, US

Assignee:

Pharsight Corporation - Mountain View CA

International Classification:

G06F003/00
G06F003/14
G06F009/455
G06G007/48
G06G007/60

US Classification:

345763, 345700, 345835, 345846, 345764, 702 19, 702 22, 702 27, 703 11, 703 12

Abstract:

A method for maintaining consistent unit relationships during graphical pharmacological computational model construction is disclosed. A graphical user interface is presented through which a user may place and connect objects representing pharmacokinetic and pharmacodynamic elements. The user may specify units definitions for variables and constants using unit expressions. As the objects are converted into an internal format representing the statements of the corresponding computational model, the unit expressions are included in this internal format as multidimensional data type information. This multidimensional data type information is regularly and automatically propagated for each statement in the internal format to identify inconsistent units. When such inconsistent units are identified, a warning message is generated to notify the user, substantially immediately after the inconsistent units are created.

Author:

Michael R. Dunlavey

ISBN #:

0442017405