Michael Albert Costanzo

US Patent:

6469036, Oct 22, 2002

Filed:

Jan 13, 2000

Appl. No.:

09/482802

Inventors:

Michael J. Costanzo - Ivyland PA
Bruce E. Maryanoff - Forest Grove PA
Stephen C. Yabut - North Wales PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3140

US Classification:

514359, 514361, 514362, 514363, 514365, 514367, 514374, 514375, 514376, 514397, 514 2, 514 19, 548127, 548180, 548200, 548214, 548217, 548236, 548248, 548255, 5482668, 5483061, 5483147, 5483611

Abstract:

The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

US Patent:

6495523, Dec 17, 2002

Filed:

Jul 20, 2000

Appl. No.:

09/620510

Inventors:

Michael J. Costanzo - Ivyland PA
Bruce E. Maryanoff - New Hope PA
Richard P. Shank - Blue Bell PA

Assignee:

Ortho McNeil-Pharmaceutical, Inc. - Raritan NJ

International Classification:

A01N 6100

US Classification:

514 23, 514 1, 514111, 514118, 514439, 514455, 514459, 514463

Abstract:

Anticonvulsant compounds of the general formula I: where X, R , R , R , R , R , and R are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal injury, non-fatal cardiac arrest, or major surgical procedures. Furthermore, pharmaceutical compositions containing a compound of formula I as well as methods for their use are disclosed.

US Patent:

7132418, Nov 7, 2006

Filed:

Jul 25, 2002

Appl. No.:

10/205355

Inventors:

Michael J. Costanzo - Ivyland PA, US
Stephen C. Yabut - North Wales PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A01N 43/62

US Classification:

514219, 514241, 514247, 514248, 51425506, 5142661, 514301, 514307, 544216, 544224, 544235, 544237, 544256, 544283, 544355, 544406, 546114, 546116

Abstract:

The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

US Patent:

7718673, May 18, 2010

Filed:

Jan 16, 2003

Appl. No.:

10/345808

Inventors:

Michael J. Costanzo - Ivyland PA, US
William J. Hoekstra - Chapel Hill NC, US
Bruce E. Maryanoff - Forest Grove PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61P 9/00
A61P 19/10
A61K 31/445
C07D 211/00
C07D 401/00
C07D 405/00
C07D 409/00

US Classification:

514315, 514318, 514326, 514330, 546193, 546208, 546212, 546214, 546226, 546245

Abstract:

The invention is directed to novel isonipecotamide derivatives of Formula (I):.

US Patent:

8158792, Apr 17, 2012

Filed:

Nov 19, 2008

Appl. No.:

12/313289

Inventors:

Michael J. Costanzo - Ivyland PA, US
Stephen C. Yabut - Perkasie PA, US
Brett Tounge - Blue Bell PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Han-Cheng Zhang - Lansdale PA, US

Assignee:

Janssen Pharmaceutica N.V.

International Classification:

C07D 491/107
A61K 31/438

US Classification:

546 17, 514278

Abstract:

The present invention is directed to a compound of Formula (I):.

US Patent:

8536189, Sep 17, 2013

Filed:

Mar 1, 2012

Appl. No.:

13/409559

Inventors:

Michael J. Costanzo - Ivyland PA, US
Stephen C. Yabut - Perkasie PA, US
Brett Tounge - Blue Bell PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Han-Cheng Zhang - Lansdale PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

C07D 407/02
A61K 31/438

US Classification:

514278, 546 17

Abstract:

The present invention is directed to a compound of Formula (I):.

US Patent:

20080306044, Dec 11, 2008

Filed:

Jun 6, 2008

Appl. No.:

12/134291

Inventors:

MICHAEL J. COSTANZO - Ivyland PA, US
David F. McComsey - Warminster PA, US
Stephen C. Yabut - Perkasie PA, US
Han-Cheng Zhang - Lansdale NJ, US

International Classification:

A61K 31/55
C07D 223/14
A61P 9/10
A61P 9/12

US Classification:

51421202, 540543

Abstract:

The present invention is directed to a compound of Formula (I) or a form thereof:wherein U, V, W and Ring A are as defined herein, useful as vasopressin receptor antagonists.

US Patent:

20110082306, Apr 7, 2011

Filed:

Mar 24, 2009

Appl. No.:

12/933971

Inventors:

Michael J. Costanzo - Ivyland PA, US
Mitul N. Patel - Union NJ, US
Paul F. Vogt - Albany NY, US

International Classification:

C07J 51/00

US Classification:

552505

Abstract:

Steroids are well known, medicinal relevant, chemical entities. There are numerous steroids which have fully or partially reduced ‘A’ rings. These fully or partially reduced ‘A’ rings have been reduced in the past through Birch and other dissolving metal reductions. Novel reducing conditions for steroid substrates are described which utilizes stabilized alkali metal-silica gel materials. The invention relates to a method for reducing a double bond within a steroid by contacting an unsaturated steroid having a phenyl ring with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a proton source under reaction conditions sufficient to form a reduced steroid having a diene structure.