Megan S Lim

Address:

5400 Meadowcrest Dr, Ann Arbor, MI 48105

Phone:

734 998-1228

VIN:

4JGBB8GB6BA693836

Make:

MERCEDES-BENZ

Model:

M-CLASS

Year:

2011

US Patent:

20140030711, Jan 30, 2014

Filed:

Jun 28, 2013

Appl. No.:

13/931177

Inventors:

Kojo S.J. Elenitoba-Johnson - Ann Arbor MI, US
Megan S. Lim - Ann Arbor MI, US
Mark J. Kiel - Ann Arbor MI, US
Thirunavukkarasu Velusamy - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The present invention relates to methods and biomarkers for detection and characterization of lymphoma (e.g., splenic marginal zone lymphoma) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).

US Patent:

20190042697, Feb 7, 2019

Filed:

Oct 9, 2018

Appl. No.:

16/155046

Inventors:

- Ann Arbor MI, US
Kojo Elenitoba-Johnson - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

G06F 19/24
G06F 19/28
G16H 50/20
G06F 19/18

Abstract:

Computer-implemented methods for automating identification and prioritization of genomic variants are disclosed. Such methods employ a rule set to analyze information regarding statistical frequency of variants in a dataset and metrics indicating biological relatedness to generate a priority-score indicative of the relevance of each variant in the dataset. The methods perform both variant frequency normalization and universal pairwise variant comparisons across the datasets to automatically calculate the likelihood that each variant is significant to a disease or other biological phenomenon under study. Priority-scores are calculated for the variants based upon such pairwise comparisons, and the results are organized into a priority ranking, which may be used to categorize the results into data subsets for display to a user.

US Patent:

20180010103, Jan 11, 2018

Filed:

Jan 29, 2016

Appl. No.:

15/547327

Inventors:

- Ann Arbor MI, US
Mark J. Kiel - Ann Arbor MI, US
Helmut Weigelin - Ann Arbor MI, US
Noah A. Brown - Ann Arbor MI, US
Bryan L. Betz - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

C12N 9/12
G01N 33/574
C12Q 1/68

Abstract:

The present invention relates to methods and biomarkers for detection and characterization of Langerhans cell histiocytosis in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples). In particular, the present invention provides compositions and methods for diagnosing a patient as having a Langerhans cell histiocytosis by identifying mutations in the MAP2K1 gene or gene products.

US Patent:

20180010196, Jan 11, 2018

Filed:

Jan 29, 2016

Appl. No.:

15/547325

Inventors:

- Ann Arbor MI, US
Mark J. Kiel - Ann Arbor MI, US
Delphine Rolland - Ann Arbor MI, US
Bryan L. Betz - Ann Arbor MI, US
Nathanael G. Bailey - Ann Arbor MI, US
Thirunavukkarasu Velusamy - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

C12Q 1/68

Abstract:

Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions (e.g., recurrent translocations involving TYK2) as diagnostic markers and clinical targets for cutaneous CD30-positive lymphoproliferative disorders (e.g., lymphomatoid papulosis; primary cutaneous anaplastic large cell lymphoma).

US Patent:

20160132506, May 12, 2016

Filed:

Nov 11, 2015

Appl. No.:

14/938509

Inventors:

- Ann Arbor MI, US
Kojo Elenitoba-Johnson - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

G06F 17/30

Abstract:

A data analysis method and computer system electronically mines published articles from existing medical literature sources to discover associations that may exist between various diseases and various genes and/or gene mutations or other genetic changes. The method and system then organizes, categorizes and prioritizes the discovered associations in accordance with the strength of evidence supporting these associations. The resulting information can then be integrated into the processing of genome sequencing data to more quickly determine what genome sequencing data is of most relevance for clinical decision makings.

US Patent:

20150193578, Jul 9, 2015

Filed:

Jan 6, 2015

Appl. No.:

14/590427

Inventors:

- Ann Arbor MI, US
Kojo Elenitoba-Johnson - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

G06F 19/22

Abstract:

A genomic variant analysis method and computer system utilizing information related to variant frequency and biological consequence to determine the relative statistical significance of each variant in given genome sequence datasets. The method and system perform both variant frequency normalization and universal pairwise variant comparisons across the given genome sequence datasets to automatically identify the likelihood of any given variant as contributing to disease process or biological phenomenon under study and organize the results into a priority ranking. The priority ranking is then used to categorize the results into biologically-related data subsets for display to indicate potential for importance.

US Patent:

20150050274, Feb 19, 2015

Filed:

Aug 14, 2014

Appl. No.:

14/459928

Inventors:

- Ann Arbor MI, US
Mark J. Kiel - Ann Arbor MI, US
Thirunavukkarasu Velusamy - Ann Arbor MI, US
Anagh Sahasrabuddhe - Ann Arbor MI, US
Delphine Rolland - Ann Arbor MI, US
Megan Lim - Ann Arbor MI, US

International Classification:

C12Q 1/68
G01N 33/573

US Classification:

4241331, 506 2, 5142651, 435 74, 51421021, 5142358, 51421108

Abstract:

The present invention relates to methods and biomarkers for detection and characterization of mature T-cell neoplasias/leukemias (e.g., T-cell prolymphocytic leukemia, Sezary syndrome) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).

US Patent:

20150031061, Jan 29, 2015

Filed:

Jun 27, 2014

Appl. No.:

14/317606

Inventors:

- ANN ARBOR MI, US
Delphine Rolland - Ann Arbor MI, US
Venkatesha Basrur - Sylvania OH, US
Kevin P. Conlon - Ann Arbor MI, US
Megan S. Lim - Ann Arbor MI, US

International Classification:

C12Q 1/48
C12Q 1/37

US Classification:

435 15, 435 18

Abstract:

The present invention provides fusion proteins as biomarkers specific for chromosomal translocation-based conditions (e.g., cancer), related methods for detecting fusion protein biomarkers associated with chromosomal translocation-based conditions, related methods for quantifying amount of fusion protein expression, and related methods for diagnosing chromosomal translocation-based conditions through detection of such fusion protein biomarkers. Such fusion protein biomarkers and related methods additionally find use in research settings.