Harvey Ellis Cline - Schenectady NY, US Ali Can - Troy NY, US Xiaodong Tao - Niskayuna NY, US Robert John Filkins - Niskayuna NY, US Maximilian Lewis Seel - Albany NY, US Michael Christopher Montalto - Albany NY, US
A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.
Method And Apparatus For Detecting Irregularities In Tissue Microarrays
Ali Can - Troy NY, US Michael John Gerdes - Albany NY, US Xiaodong Tao - Niskayuna NY, US Musodiq Olatayo Bello - Niskayuna NY, US Maximilian Seel - Boston MA, US
Assignee:
General Electric Company - Niskayuna NY
International Classification:
G06K 9/36 G06K 9/62
US Classification:
382133, 382128
Abstract:
The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.
ANUP SOOD - CLIFTON PARK NY, US MICHAEL CHRISTOPHER MONTALTO - ALBANY NY, US MICHAEL GERDES - ALBANY NY, US MAXIMILIAN LEWIS SEEL - ALBANY NY, US ROBERT JOHN FILKINS - NISKAYUNA NY, US
Assignee:
GENERAL ELECTRIC COMPANY - SCHENECTADY NY
International Classification:
C12Q 1/68 C12M 3/00
US Classification:
435 6, 4352872
Abstract:
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
Method And Apparatus For Analysis Of Tissue Microarrays
Ali Can - Troy NY, US Michael John Gerdes - Albany NY, US Musodiq Olatayo Bello - Niskayuna NY, US Xiaodong Tao - Niskayuna NY, US Maximilian Seel - Boston MA, US
Assignee:
General Electric Company - Schenectady NY
International Classification:
C40B 30/00 G06K 9/00
US Classification:
506 7, 382128
Abstract:
The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information.
Anup Sood - Clifton Park NY, US Michael Christopher Montalto - Jackson NJ, US Michael Gerdes - Albany NY, US Maximilian Lewis Seel - Boston MA, US Robert John Filkins - Niskayuna NY, US
Assignee:
GENERAL ELECTRIC COMPANY - SCHENECTADY NY
International Classification:
G01N 33/53
US Classification:
436501
Abstract:
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
Anup Sood - Clifton Park NY, US Michael Christopher Montalto - Brielle NJ, US Michael Gerdes - Albany NY, US Maximilian Lewis Seel - Boston MA, US Robert John Filkins - Niskayuna NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
C40B 30/04
US Classification:
506 9
Abstract:
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
Michael Christopher Montalto - Piscataway NJ, US Michael John Gerdes - Albany NY, US Maximilian Lewis Seel - Washington DC, US Robert John Filkins - Niskayuna NY, US
Assignee:
General Electric Company - Schenectady NY
International Classification:
G01N 33/53
US Classification:
4352887, 422 69
Abstract:
Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
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