Maximilian J Seel from 1103 Birch St, Houghton, MI 49931, age 74, Phone: 906 482-9448

Systems For Analyzing Tissue Samples
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US Patent:

8060348, Nov 15, 2011
Filed:

Nov 30, 2006
Appl. No.:

11/606582
Inventors:

Harvey Ellis Cline - Schenectady NY, US
Ali Can - Troy NY, US
Xiaodong Tao - Niskayuna NY, US
Robert John Filkins - Niskayuna NY, US
Maximilian Lewis Seel - Albany NY, US
Michael Christopher Montalto - Albany NY, US
Assignee:

General Electric Company - Niskayuna NY
International Classification:

G06F 17/10
US Classification:

703 2, 702 19, 702 23, 702 32, 436 64, 382128, 382278
Abstract:

A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Method And Apparatus For Detecting Irregularities In Tissue Microarrays
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US Patent:

8369600, Feb 5, 2013
Filed:

Mar 25, 2008
Appl. No.:

12/055038
Inventors:

Ali Can - Troy NY, US
Michael John Gerdes - Albany NY, US
Xiaodong Tao - Niskayuna NY, US
Musodiq Olatayo Bello - Niskayuna NY, US
Maximilian Seel - Boston MA, US
Assignee:

General Electric Company - Niskayuna NY
International Classification:

G06K 9/36
G06K 9/62
US Classification:

382133, 382128
Abstract:

The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.

Sequential Analysis Of Biological Samples
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US Patent:

20080118916, May 22, 2008
Filed:

Nov 16, 2006
Appl. No.:

11/560599
Inventors:

ANUP SOOD - CLIFTON PARK NY, US
MICHAEL CHRISTOPHER MONTALTO - ALBANY NY, US
MICHAEL GERDES - ALBANY NY, US
MAXIMILIAN LEWIS SEEL - ALBANY NY, US
ROBERT JOHN FILKINS - NISKAYUNA NY, US
Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY
International Classification:

C12Q 1/68
C12M 3/00
US Classification:

435 6, 4352872
Abstract:

Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

Method And Apparatus For Analysis Of Tissue Microarrays
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US Patent:

20090247416, Oct 1, 2009
Filed:

Mar 25, 2008
Appl. No.:

12/055121
Inventors:

Ali Can - Troy NY, US
Michael John Gerdes - Albany NY, US
Musodiq Olatayo Bello - Niskayuna NY, US
Xiaodong Tao - Niskayuna NY, US
Maximilian Seel - Boston MA, US
Assignee:

General Electric Company - Schenectady NY
International Classification:

C40B 30/00
G06K 9/00
US Classification:

506 7, 382128
Abstract:

The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information.

Sequential Analysis Of Biological Samples
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US Patent:

20100047925, Feb 25, 2010
Filed:

Nov 3, 2009
Appl. No.:

12/611299
Inventors:

Anup Sood - Clifton Park NY, US
Michael Christopher Montalto - Jackson NJ, US
Michael Gerdes - Albany NY, US
Maximilian Lewis Seel - Boston MA, US
Robert John Filkins - Niskayuna NY, US
Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY
International Classification:

G01N 33/53
US Classification:

436501
Abstract:

Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

Sequential Analysis Of Biological Samples
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US Patent:

20120231967, Sep 13, 2012
Filed:

Apr 27, 2012
Appl. No.:

13/457531
Inventors:

Anup Sood - Clifton Park NY, US
Michael Christopher Montalto - Brielle NJ, US
Michael Gerdes - Albany NY, US
Maximilian Lewis Seel - Boston MA, US
Robert John Filkins - Niskayuna NY, US
Assignee:

GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:

C40B 30/04
US Classification:

506 9
Abstract:

Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

Sequential Analysis Of Biological Samples
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US Patent:

20140045251, Feb 13, 2014
Filed:

Oct 23, 2013
Appl. No.:

14/060650
Inventors:

Michael Christopher Montalto - Piscataway NJ, US
Michael John Gerdes - Albany NY, US
Maximilian Lewis Seel - Washington DC, US
Robert John Filkins - Niskayuna NY, US
Assignee:

General Electric Company - Schenectady NY
International Classification:

G01N 33/53
US Classification:

4352887, 422 69
Abstract:

Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.