Maud J Urbanski

US Patent:

6489321, Dec 3, 2002

Filed:

Nov 2, 2000

Appl. No.:

09/704314

Inventors:

Maud J. Urbanski - Belle Mead NJ
Robert H. K. Chen - Belle Mead NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D28110

US Classification:

51421105, 51421109, 540523, 540552

Abstract:

The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, Z, Bp, W, n, R and R are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

US Patent:

6653478, Nov 25, 2003

Filed:

Oct 23, 2001

Appl. No.:

10/047841

Inventors:

Maud J. Urbanski - Flemington NJ
Keith T. Demarest - Flemington NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D40104

US Classification:

546199, 546187, 514326, 514322

Abstract:

The invention is directed to substituted benzimidazol-2-ones of Formula I, wherein A, X, Y, m, n, R , R , R , R , and R are as described in the specification, which are useful as vasopressin receptor antagonists or Neuropeptide Y Modulators for treating conditions such as aggression, obsessive-compulsive disorders, hypertension, dysmenorrhea, congestive heart failure/cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, edema, ischemia, stroke, thrombosis, water retention, nephrotic syndrome, central nervous injuries, obesity, anorexia, hyperglycemia, diabetes, anxiety, depression, asthma, memory loss, sexual dysfunction, disorders of sleep and other circadian rhythms, and Cushings disease.

US Patent:

7084124, Aug 1, 2006

Filed:

Jul 30, 2004

Appl. No.:

10/903034

Inventors:

Mona Patel - Belle Mead NJ, US
Philip J. Rybczynski - Branchburg NJ, US
Maud Urbanski - Flemington NJ, US
Xiaoyan Zhang - Belle Mead NJ, US

Assignee:

Janssen Pharmaceutica, N.V. - Beerse

International Classification:

A01N 43/04
A61K 31/70
C07H 15/00
C07H 17/00

US Classification:

514 27, 514 23, 514 25, 536 41, 536 172, 536 173, 536 174

Abstract:

Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

US Patent:

7094763, Aug 22, 2006

Filed:

Jul 30, 2004

Appl. No.:

10/903136

Inventors:

Philip Rybczynski - Branchburg NJ, US
Maud Urbanski - Flemington NJ, US
Xiaoyan Zhang - Belle Mead NJ, US

Assignee:

Janssen Pharaceutica, N.V.

International Classification:

A01N 43/04
A61K 31/70
C07H 7/06

US Classification:

514 23, 514866, 514909, 536 111, 536 187, 536 292, 536 53, 536 54, 536 55

Abstract:

This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

US Patent:

7094764, Aug 22, 2006

Filed:

Jul 30, 2004

Appl. No.:

10/903234

Inventors:

Maud Urbanski - Flemington NJ, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 23, 514 25, 514 27, 536 41, 536 172, 536 173, 536 174, 548257, 5483351

Abstract:

This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

US Patent:

7129220, Oct 31, 2006

Filed:

Jul 30, 2004

Appl. No.:

10/903233

Inventors:

Mary Pat Beavers - New Hope PA, US
Mona Patel - Belle Mead NJ, US
Philip Rybczynski - Branchburg NJ, US
Maud Urbanski - Flemington NJ, US
Xiaoyan Zhang - Belle Mead NJ, US

Assignee:

Janssen Pharmaceutica N.V

International Classification:

A01N 43/04
A61K 31/70
C07H 15/00
C07H 17/00

US Classification:

514 27, 536 41, 536 172, 536 173, 536 174, 514 23, 514 25

Abstract:

Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

US Patent:

7482330, Jan 27, 2009

Filed:

Jun 15, 2006

Appl. No.:

11/453728

Inventors:

Philip Rybczynski - Branchburg NJ, US
Maud Urbanski - Flemington NJ, US
Xiaoyan Zhang - Belle Mead NJ, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 23, 514866, 514909

Abstract:

This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

US Patent:

7511020, Mar 31, 2009

Filed:

Jun 15, 2006

Appl. No.:

11/453727

Inventors:

Maud Urbanski - Flemington NJ, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 25, 514 23, 514 27

Abstract:

This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.