Matthew Volgraf from 4655 Park Blvd, Oakland, CA 94602, age 43

Us Patents

Photoreactive Regulator Of Glutamate Receptor Function And Methods Of Use Thereof
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US Patent:

8178496, May 15, 2012
Filed:

Dec 18, 2008
Appl. No.:

12/338880
Inventors:

Dirk Trauner - San Francisco CA, US
Ehud Y. Isacoff - Berkeley CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, ES
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07C 323/12
A61A 38/00
US Classification:

514 173, 514 174, 435 78, 435334, 4352921
Abstract:

The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulator non-covalently associated with the glutamate receptor. Also provided are cells and membranes comprising a subject light-regulated glutamate receptor. The present invention further provides methods of modulating glutamate receptor function, involving use of light. The present invention further provides methods of identifying agents that modulate glutamate receptor function.

Photoreactive Regulator Of Protein Function And Methods Of Use Thereof
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US Patent:

8309350, Nov 13, 2012
Filed:

Feb 1, 2012
Appl. No.:

13/364105
Inventors:

Ehud Y. Isacoff - Berkeley CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - Munich, DE
Matthew R. Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, ES
Katharine Borges - Centerport NY, US
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C12N 5/00
A61K 38/00
US Classification:

435325, 514 173, 514 174, 549540, 435 72, 435 41
Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

Photoreactive Regulator Of Protein Function And Methods Of Use Thereof
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US Patent:

20070128662, Jun 7, 2007
Filed:

Nov 17, 2006
Appl. No.:

11/601591
Inventors:

Ehud Isacoff - Berkeley CA, US
Richard Kramer - Oakland CA, US
Dirk Trauner - San Francisco CA, US
Matthew Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Langa - Barcelona, ES
International Classification:

G01N 33/53
C07K 14/195
C07H 21/04
C12P 21/06
C12N 15/74
C12N 1/21
A61K 38/16
US Classification:

435007100, 435069100, 435252300, 435471000, 530350000, 536023500, 514012000
Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

Photoreactive Regulator Of Protein Function And Methods Of Use Thereof
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US Patent:

20130137113, May 30, 2013
Filed:

Nov 8, 2012
Appl. No.:

13/671908
Inventors:

The Regents of the University of California - Oakland CA, US
Richard H. Kramer - Oakland CA, US
Dirk Trauner - Munich, DE
Matthew R. Banghart - Oakland CA, US
Matthew Volgraf - Oakland CA, US
Pablo Ignacio Gorostiza Langa - Barcelona, SP
Katharine Borges - Centerport NY, US
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:

G01N 33/53
US Classification:

435 71
Abstract:

The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.

Sulfonylurea Compounds As Inhibitors Of Interleukin-1 Activity
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US Patent:

20210261568, Aug 26, 2021
Filed:

Jan 15, 2021
Appl. No.:

17/150380
Inventors:

- South San Francisco CA, US
James M. VEAL - South San Francisco CA, US
Lynnie Lin TRZOSS - South San Francisco CA, US
Christopher MCBRIDE - South San Francisco CA, US
Richard M. PASTOR - South San Francisco CA, US
Steven Thomas STABEN - South San Francisco CA, US
Craig STIVALA - South San Francisco CA, US
Matthew VOLGRAF - South San Francisco CA, US
Assignee:

Genentech, Inc. - South San Francisco CA
International Classification:

C07D 498/04
Abstract:

The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

Sulfonimidamide Compounds As Inhibitors Of Interleukin-1 Activity
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US Patent:

20210253596, Aug 19, 2021
Filed:

Jan 15, 2021
Appl. No.:

17/150349
Inventors:

- South San Francisco CA, US
Lynnie Lin TRZOSS - South San Francisco CA, US
Amogh BOLOOR - South San Francisco CA, US
Nadezda V. SOKOLOVA - South San Francisco CA, US
Richard M. PASTOR - South San Francisco CA, US
Steven Thomas STABEN - South San Francisco CA, US
Craig STIVALA - South San Francisco CA, US
Matthew VOLGRAF - South San Francisco CA, US
Sarah M. BRONNER - South San Francisco CA, US
Assignee:

Genentech, Inc. - South San Francisco CA
International Classification:

C07D 498/04
C07D 231/18
C07D 471/04
C07D 487/04
C07D 513/04
A61P 31/04
A61P 31/12
A61P 31/18
A61P 31/16
A61P 31/14
Abstract:

The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

Oxadiazole Transient Receptor Potential Channel Inhibitors
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US Patent:

20200308161, Oct 1, 2020
Filed:

Jun 16, 2020
Appl. No.:

16/903020
Inventors:

- South San Francisco CA, US
Huifen Chen - South San Francisco CA, US
Lea Constantineau-Forget - Montreal, CA
Robin Larouche-Gauthier - Montreal, CA
Luce Lépissier - Montreal, CA
Francis Beaumier - Montreal, CA
Martin Déry - Montreal, CA
Chantal Grand-Maître - Montreal, CA
Claudio Sturino - Montreal, CA
Matthew Volgraf - South San Francisco CA, US
Elisia Villemure - South San Francisco CA, US
Assignee:

Genentech, Inc. - South San Francisco CA
International Classification:

C07D 413/14
C07D 473/30
C07D 471/04
A61P 29/00
C07D 513/04
C07D 487/04
A61P 25/00
C07D 498/04
A61K 31/427
A61P 23/00
A61P 11/00
Abstract:

The invention relates to methods of using compounds formula I:and pharmaceutically acceptable salts thereof wherein A, X, R, Rand n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Oxadiazole Transient Receptor Potential Channel Inhibitors
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US Patent:

20200002340, Jan 2, 2020
Filed:

Sep 3, 2019
Appl. No.:

16/558718
Inventors:

- South San Francisco CA, US
Brian SAFINA - South San Francisco CA, US
Daniel SHORE - South San Francisco CA, US
Jack TERRETT - South San Francisco CA, US
Elisia VILLEMURE - South San Francisco CA, US
Matthew VOLGRAF - South San Francisco CA, US
Stuart WARD - Harlow, GB
Aijun LU - Beijing, CN
Robin LAROUCHE-GAUTHIER - Montreal, CA
Francis BEAUMIER - Montreal, CA
Martin DERY - Montreal, US
Lea CONSTANTINEAU-FORGET - Montreal, CA
Chantal GRAND-MAITRE - Montreal, CA
Luce LEPISSIER - Montreal, CA
Assignee:

Genentech, Inc. - South San Francisco CA
International Classification:

C07D 473/30
C07D 471/04
C07D 487/04
C07D 473/08
Abstract:

The invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Resumes

Senior Scientist

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Location:

4655 Park Boulevard Way, Oakland, CA 94610

Industry:

Pharmaceuticals

Work:

Genentech Jun 2010 - Jul 2017
Scientist
Genentech Jun 2010 - Jul 2017
Senior Scientist
Memorial Sloan Kettering Cancer Center Jul 2008 - Jun 2010
Postdoctoral Fellow

Education:

University of California, Berkeley 2003 - 2008
Doctorates, Doctor of Philosophy, Chemistry University of Pennsylvania 1999 - 2003
Bachelors, Bachelor of Arts, Chemistry

Skills:

Medicinal Chemistry
Organic Synthesis
Drug Discovery
Ion Channels
Chemistry
Natural Products

Languages:

English

Scientist At Genentech

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Position:

Scientist at Genentech

Location:

San Francisco Bay Area

Industry:

Pharmaceuticals

Work:

Genentech since Jun 2010
Scientist
Memorial Sloan-Kettering Cancer Center Jul 2008 - Jun 2010
Postdoctoral Fellow

Education:

University of California, Berkeley 2003 - 2008
Ph.D., Chemistry University of Pennsylvania 1999 - 2003
B.A., Chemistry

Skills:

Medicinal Chemistry
Ion Channels
Organic Synthesis
Drug Discovery
Chemistry
Natural Products

Honor & Awards:

American Cancer Society Postdoctoral Fellow (2008–2010) Roche Excellence in Chemistry Award (2007) American Chemical Society Medicinal Chemistry Division Predoctoral Fellowship (2006) American Chemical Society Award (Senior Chemistry Award), University of Pennsylvania (2003) Phi Beta Kappa Society, University of Pennsylvania (2003) Hiram S. Lukens Memorial Scholar (Sophomore Chemistry Award), University of Pennsylvania (2002) CRC Freshman Chemistry Award, University of Pennsylvania (2000) Dean’s Honor List, University of Pennsylvania (1999–2003)