Matthew F Hockin

US Patent:

20060015261, Jan 19, 2006

Filed:

Mar 10, 2003

Appl. No.:

10/507661

Inventors:

Kenneth Mann - Grand Isle VT, US
Stephen Everse - Shelburne VT, US
Matthew Hockin - Salt Lake City UT, US
Kenneth Jones - Montpeller VT, US

International Classification:

G06F 19/00
G01N 33/48
G01N 33/50

US Classification:

702019000

Abstract:

A computer program product for predicting the speed and efficacy of a blood-clotting agent is disclosed. The product comprises a computer usable medium having computer readable program code means embodied in the medium for causing an application program to execute on a computer with a database for storing data therein. The computer readable program code means comprises a first computer readable program code means for causing the computer to enter data into the database from a user interface, a second computer readable program code means for causing the computer to enter chemical equations into the database according to a user's input, a third computer readable program code means for causing the computer to compile differential equations corresponding to the chemical equations, a fourth computer readable program code means for causing the computer to solve the differential equations, and a fifth computer readable program code means for causing the computer to display the results of the solution to the differential equations.

US Patent:

20090298103, Dec 3, 2009

Filed:

May 20, 2009

Appl. No.:

12/454677

Inventors:

Kenneth G. Mann - Grand Isle VT, US
Kathleen B. Ziedins - Waterbury Center VT, US
Thomas Orfeo - Westford VT, US
Matthew F. Hockin - Salt Lake City UT, US
Stephen J. Everse - South Burlington VT, US

Assignee:

The University of Vermont and State Agriculture College - Burlington VT

International Classification:

C12Q 1/56
G01N 33/48

US Classification:

435 13, 702 19

Abstract:

Featured are methods for assessing hemostatic risk including the risk for ACS. Such methods include acquiring blood/plasma composition based on a biological sample obtained from a subject, determining parameters associated with blood clotting, simulating in silico blood clotting using the determined parameters and comparing the results of such simulation to a reference and to determine the hemostatic risk from said comparing. In further embodiments, such methods further include selecting a treatment regime or protocol based on the results of such comparing. In yet further embodiments, such methods further include assessing the efficacy of medicants, drugs and the like of a given treatment protocol such as by simulating in silico the application of such medicants, drugs and the like.

US Patent:

20060014934, Jan 19, 2006

Filed:

May 17, 2005

Appl. No.:

11/131091

Inventors:

Stephen Everse - Shelburne VT, US
Ty Adams - Cambridge, GB
Matthew Hockin - Salt Lake City UT, US
Kenneth Mann - Grand Isle VT, US

International Classification:

C07K 14/745
G01N 33/48
A61K 38/48

US Classification:

530384000, 702019000

Abstract:

The present invention shows the crystal structure of protein C inactivated factor Va (A-A-C-C) that depicts a novel domain arrangement. The newly disclosed orientation has implications for binding to membranes essential for function. A high-affinity calcium binding site and a copper binding site have been identified, neither of which show a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for generation of models of coagulation factors.

US Patent:

20210371895, Dec 2, 2021

Filed:

Oct 1, 2019

Appl. No.:

17/282104

Inventors:

- Salt Lake City UT, US
- Marcy-L'Etoile, FR
Stefanie Marxreiter - Salt Lake City UT, US
Eric Lo - Salt Lake City UT, US
Laurent Eugène Paul Drazek - Grenoble, FR
Matthew F. Hockin - Salt Lake City UT, US
Joshua Earle Jackson - Cottonwood Heights UT, US

International Classification:

C12Q 1/18
C12Q 1/6806
C12Q 1/6851

Abstract:

Methods, sample vessels, and instruments are provided for determining antibiotic resistance of a bacterium.