Matthew L Hillwig

US Patent:

7854946, Dec 21, 2010

Filed:

May 29, 2008

Appl. No.:

12/129391

Inventors:

Matthew Lee Hillwig - Ames IA, US

Assignee:

Iowa State University Research Foundation, Inc. - Ames IA

International Classification:

A61K 36/38

US Classification:

424730

Abstract:

The metabolic fingerprint and anti-inflammatory activity and anti-HIV activity of is disclosed. High performance liquid chromatography (HPLC) analysis shows that contains a family of compounds, including some not previously observed in other species. extracts and fractions from these extracts reduce prostaglandin E2 synthesis in mammalian macrophages and inhibit HIV in infected HeLa cells. The present invention provides extracts and fractions thereof from for use in pharmaceutical compositions and methods for the treatment or inhibition of inflammation, prostaglandin E-mediated disease, disorder or condition, a cyclooxygenase-mediated disease, disorder or condition, or an HIV infection.