H. Bosch - Bryn Mawr PA, US Matthew Hilborn - King of Prussia PA, US Douglas Hovey - Trooper PA, US Laura Kline - Harleysville PA, US Robert Lee - King of Prussia PA, US John Pruitt - Collegeville PA, US Niels Ryde - Malvern PA, US Tuula Ryde - Malvern PA, US Shuqian Xu - King of Prussia PA, US
Assignee:
Elan Pharma International, Ltd.
International Classification:
A61K009/14
US Classification:
424/489000
Abstract:
The present invention relates to liquid dosage compositions of stable nanoparticulate active agents. The liquid dosage compositions of the invention include osmotically active crystal growth inhibitors that stabilize the nanoparticulate active agents against crystal and particle size growth of the active agent.
Liquid Dosage Compositions Of Stable Nanoparticulate Active Agents
H. William BOSCH - Bryn Mawr PA, US Matthew R. HILBORN - Spring City PA, US Douglas C. HOVEY - Gilbertsville PA, US Laura J. KLINE - Harleysville PA, US Robert W. LEE - Boyerstown PA, US John D. PRUITT - Suwansee GA, US Niels P. RYDE - Malvern PA, US Tuula A. RYDE - Malvern PA, US Shuqian XU - Sunnyvale CA, US
The present invention relates to liquid dosage compositions of stable nanoparticulate active agents. The liquid dosage compositions of the invention include osmotically active crystal growth inhibitors that stabilize the nanoparticulate active agents against crystal and particle size growth of the active agent.
Gamma Irradiation Of Solid Nanoparticulate Active Agents
The present invention relates to methods for terminal sterilization of solid forms of nanoparticulate active agent compositions via gamma irradiation. The nanoparticulate active agent has an effective average particle size of less than about 2 microns, prior to incorporation into a solid form for sterilization. The resultant sterilized compositions exhibit excellent redispersibility, homogeneity, and uniformity. Also encompassed are compositions made via the described method and methods of treating animals and humans using such compositions.
Lehigh University 2005 - 2010
Master of Business Administration, Masters, Engineering
Penn State University 1992 - 1996
Bachelors, Bachelor of Science, Chemical Engineering
Skills:
Contract Writing Negotiating Contracts Technology Development Licensing Agreements Drug Delivery Drug Development Process Engineering Analytical Chemistry Negotiation Budget Management Collaborative Working Alliances Manufacturing Engineering Chemical Engineering Mba Pharmaceutical Development Consultation Business Development Licensing Negotiations Technology Management Dispute Resolution Strategic Technology Planning Technology Roadmapping Influence Without Authority Mentoring Licensing Biopharmaceuticals Gmp Pharmaceutical Industry Product Development Validation Dissolution Clinical Development Fda Biotechnology Drug Discovery Technology Transfer R&D Formulation U.s. Food and Drug Administration Research and Development Vaccines Sop Cleaning Validation