Matthew M Ames

US Patent:

20090208944, Aug 20, 2009

Filed:

Dec 8, 2006

Appl. No.:

12/096723

Inventors:

Matthew P. Goetz - Rochester MN, US
James N. Ingle - Rochester MN, US
Richard M. Weinshilboum - Rochester MN, US
Fergus J. Couch - Rochester MN, US
Matthew M. Ames - Rochester MN, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials that involve assessing a breast cancer patient's cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) genotype to determine the likelihood of the beast cancer patient to experience breast cancer relapse or death are provided. Methods and materials that involve assessing the likelihood that a breast cancer patient being treated with tamoxifen will experience side effects such as hot flashes also are provided.

US Patent:

20100248223, Sep 30, 2010

Filed:

May 18, 2007

Appl. No.:

12/301258

Inventors:

Matthew P. Goetz - Rochester MN, US
James N. Ingle - Rochester MN, US
Fergus J. Couch - Rochester MN, US
Matthew M. Ames - Rochester MN, US

Assignee:

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials for using the ratio of HOXB13 polypeptide expression to IL-17BR polypeptide expression, CYP2D6 genotype, medication history, or combinations thereof to determine the likelihood of a breast cancer patient to experience breast cancer relapse or death are provided.

US Patent:

20100311606, Dec 9, 2010

Filed:

May 7, 2008

Appl. No.:

12/599252

Inventors:

Liewei Wang - Rochester MN, US
Richard M. Weinshilboum - Rochester MN, US
Liang Li - Rochester MN, US
Brooke L. Fridley - Rochester MN, US
Krishna Kalari - Rochester MN, US
Daniel Schaid - Rochester MN, US
Matthew M. Ames - Rochester MN, US

International Classification:

C40B 30/04

US Classification:

506 9

Abstract:

Materials and methods for evaluating cellular response to therapeutic agents.

US Patent:

20110136913, Jun 9, 2011

Filed:

Aug 19, 2009

Appl. No.:

13/059590

Inventors:

Matthew P. Goetz - Rochester MN, US
James N. Ingle - Rochester MN, US
Vera J. Suman - Saint Charles MN, US
Matthew M. Ames - Rochester MN, US
Carol Reynolds - Rochester MN, US

International Classification:

A61K 31/138
C12Q 1/02
C12Q 1/68
G01N 33/574
A61P 35/00

US Classification:

514648, 435 29, 435 611, 435 723

Abstract:

This document provides methods and materials related to assessing and treating breast cancer patients. For example, methods and materials that involve assessing a breast cancer patient to determine whether the patient has (1) cancer cells that over express HER-2 polypeptides or comprise a HER-2 amplification and (2) at least an intermediate CYP2D6 metabolizer status are provided.

US Patent:

51069482, Apr 21, 1992

Filed:

Aug 28, 1990

Appl. No.:

7/574294

Inventors:

David H. Kinder - Pullman WA
Matthew M. Ames - Rochester MN

Assignee:

Mao Foundation for Medical Education and Research - Rochester MN

International Classification:

C07K 500
C07K 700
A61K 3700
A01N 5508

US Classification:

530331

Abstract:

A method is provided for inhibiting growth of cancer cells comprising contacting said cells with an effective growth-inhibiting amount of a compound of the formula (II): ##STR1## or a physiologically acceptable salt thereof, wherein A. sup. 1 and A. sup. 2 are individually L-amino acid residues selected from the group consisting of Ala, Pro, Gly, Glu, Leu, Lys, Phe, Ser, Val, Ile, Arg, Tyr, Thr, Asp, Asn and Gly; R. sup. 1 is C. sub. 1 -C. sub. 6 (alkyl) which is unsubstituted or is substituted with an aromatic substituent or one or more in-chain bivalent groups selected from the group consisting of --O--, --CO--, --S--, --NH--, --CONH--, CH. dbd. CH--, and --SO. sub. 2 --; Y. sup. 1 and Y. sup. 2 are each H, or taken together from a moiety derived from a dihydroxy compound, and R. sup. 1 is H or an N-terminal protecting group.

US Patent:

51590603, Oct 27, 1992

Filed:

Jan 21, 1992

Appl. No.:

7/823674

Inventors:

David H. Kinder - Pullman WA
Matthew M. Ames - Rochester MN

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

A61K 3700
A01N 5508
C07K 500
C07K 700

US Classification:

530331

Abstract:

A method is provided for inhibiting growth of cancer cells comprising contacting said cells with an effective growth-inhibiting amount of a compound of the formula (II): ##STR1## or a physiologically acceptable salt thereof, wherein A. sup. 1 and A. sup. 2 are individually L-amino acid residue selected from the group consisting of Ala, Pro, Gly, Glu, Leu, Lys, Phe, Ser, Vl, Ile, Arg, Tyr, Thr, Asp, Asn and Gly; R. sup. 1 is C. sub. 1 -C. sub. 6 (alkyl) which is unsubstituted or is substituted with an aromatic substituent or one or more in-chain bivalent groups selected from the group consisting of --O--, --CO--, --S--, --NH--, --CONH--, CH. dbd. CH--, and --SO. sub. 2 --; Y. sup. 1 and Y. sup. 2 are each H, or taken together form a moiety derived from a dihydroxy compound, and R. sup. 1 is H or an N-terminal protecting group.

US Patent:

49636553, Oct 16, 1990

Filed:

May 27, 1988

Appl. No.:

7/199891

Inventors:

David H. Kinder - Rochester MN
Matthew M. Ames - Rochester MN

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C07K 508

US Classification:

530331

Abstract:

A method of inhibiting protease activity, growth, and colony formation in mammalian tumor cells by boronic acid analogs of amino acids, dipeptides and tripeptides. A method of coupling a boronic acid analog of an amino acid to other N-protected amino acids or N-protected dipeptides and compositions formed from the coupled products.

US Patent:

50045938, Apr 2, 1991

Filed:

Apr 17, 1989

Appl. No.:

7/339481

Inventors:

Matthew M. Ames - Rochester MN
John S. Kovach - Rochester MN

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

A61K 3171
A61K 3166
A61K 3153
A61K 3324

US Classification:

424 10

Abstract:

A method is provided for reducing the side effects of chemotherapy with hexamethylmelamine (HMM) comprising intravelously administering a stabilized solution of HMM in an aqueous lipid dispersion, so that the central nervous system toxicity associated with oral HMM administration is reduced or eliminated.

Author:

Matthew M. Ames

ISBN #:

0444805184

Author:

Matthew M. Ames

ISBN #:

0683181114