Martin J Wensley

US Patent:

6682716, Jan 27, 2004

Filed:

May 13, 2002

Appl. No.:

10/146515

Inventors:

Craig C. Hodges - Walnut Creek CA
Peter M. Lloyd - Walnut Creek CA
Daniel Mufson - Napa CA
Daniel D. Rogers - Oakland CA
Martin J. Wensley - San Francisco CA

Assignee:

Alexza Molecular Delivery Corporation - Palo Alto CA

International Classification:

A61K 912

US Classification:

424 45, 424 46, 424450, 424789, 514 54, 514220, 514252, 12820014, 12820315

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1 for inhalation therapy. In a composition aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200 nm, or 10 nm and 100 nm.

US Patent:

7090830, Aug 15, 2006

Filed:

Nov 20, 2003

Appl. No.:

10/718982

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424489, 424499, 514958, 12820014, 12820024, 12820315

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0. 05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

7513781, Apr 7, 2009

Filed:

Dec 27, 2006

Appl. No.:

11/645859

Inventors:

Charles Galauner - Elburn IL, US
Gregory Menn - Naperville IL, US
Richard A. Nelson - Geneva IL, US
Hazelton P. Avery - Batavia IL, US
Timothy E. Purkis - Naperville IL, US
Richard A. Faje - Darien IL, US
Ryan D. Timmons - Mountain View CA, US
Andrew J.G. Kelly - Redwood City CA, US
Martin J. Wensley - Los Gatos CA, US

Assignee:

Molex Incorporated - Lisle IL
Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

H01R 12/00

US Classification:

439 70, 439509

Abstract:

An improved heating element connector assembly includes an insulative, rectangular frame with a central opening, and a plurality of conductive terminals which are press fit into openings in the frame. The terminals are spaced apart from each other lengthwise of two opposing sidewalls of the frame, and pairs of terminals are aligned with each other between the two sidewalls. A plurality of conductive strips are held together in an assembly and the ends of the strips are interconnected along two spaced apart lines by carrier members that may be molded over the ends of the conductive strips. The carrier members extend down into cavities on the frame and terminals are pushed into the cavities to bear against the ends of the strips and effect an electrical connection between the terminals and the strips.

US Patent:

7537009, May 26, 2009

Filed:

May 13, 2002

Appl. No.:

10/146088

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Daniel Mufson - Napa CA, US
Daniel D. Rogers - Oakland CA, US
Soonho Song - Stanford CA, US
Martin J. Wensley - San Francisco CA, US
Daniel J. Myers - Mountain View CA, US
Jeffrey A. McKinney - Foster City CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61L 9/04

US Classification:

12820316, 12820014, 424 46

Abstract:

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 C. /s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.

US Patent:

7540286, Jun 2, 2009

Filed:

Jun 3, 2004

Appl. No.:

10/861554

Inventors:

Steven D. Cross - Alamo CA, US
Mathieu Herbette - Sunnyvale CA, US
Andrew J. G. Kelly - Palo Alto CA, US
Daniel J. Myers - Mountain View CA, US
William W. Shen - Stanford CA, US
Ryan D. Timmons - Mountain View CA, US
Curtis Tom - San Mateo CA, US
Justin M. Virgili - Palo Alto CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 11/00

US Classification:

12820417, 12820326, 12820327

Abstract:

Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

US Patent:

7550133, Jun 23, 2009

Filed:

Nov 20, 2003

Appl. No.:

10/719899

Inventors:

Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424489, 424434, 424499, 514958, 12820014, 12820024, 12820315

Abstract:

Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described.

US Patent:

7585493, Sep 8, 2009

Filed:

Aug 4, 2003

Appl. No.:

10/633877

Inventors:

Ron L. Hale - Woodside CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 514958, 12820014, 12820015, 12820024

Abstract:

An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0. 05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.

US Patent:

7645442, Jan 12, 2010

Filed:

Aug 4, 2003

Appl. No.:

10/633876

Inventors:

Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Dennis W. Solas - San Francisco CA, US
Soonho Song - Palo Alto CA, US
Curtis Tom - San Mateo CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 12820014, 12820024, 12820315, 514958

Abstract:

A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 C. , and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.