Dr. Zoller graduated from the University of Kentucky College of Medicine in 1984. He works in Jacksonville, FL and specializes in Family Medicine. Dr. Zoller is affiliated with St Vincents Medical Center and St Vincents Medical Center Southside.
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Bottstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07H 2104 C12N 964
US Classification:
435226
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Or Fibrin Specific Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964 C12N 1558 C12N 1570 C12N 1586
US Classification:
435226
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - San Francisco CA
International Classification:
C12N 950 C12N 964 A61K 3849 C07H 1512
US Classification:
424 9464
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Or Fibrin Specific Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - So. San Francisco CA
International Classification:
A61K 3849 C12N 950 C12N 964 C12N 1555
US Classification:
424 9464
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymognic Or Fibrin Specific Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964
US Classification:
435226
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Or Fibrin Specific Properties And Substituted At Amino Acid Positions 296-299, Dna Molecules Encoding Them, Vectors, And Host Cells
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964 C12N 1558 A61K 37547
US Classification:
424 9464
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Or Fibrin Specific Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Carlos CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 950 C12N 964 C12Q 138 C07H 1512
US Classification:
435 23
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Tissue Plasminogen Activator Having Zymogenic Or Fibrin Specific Properties
Stephen Anderson - Princeton NJ William F. Bennett - San Mateo CA David Botstein - Belmont CA Deborah L. Higgins - San Mateo CA Nicholas F. Paoni - Moraga CA Mark J. Zoller - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 3848 C12N 964 C12N 1563
US Classification:
435226
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
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Mark Zoller Big 5 Hall of Fame Inductee
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Weekend Coffee with MarkZ 12/24/2022
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Columbia River GorgeFrom "suit & tie" manager at UPS to full time whitewater river guide at Zoller's Outdoor Odysseys, my business life has "rapidly" changed over the past couple... From "suit & tie" manager at UPS to full time whitewater river guide at Zoller's Outdoor Odysseys, my business life has "rapidly" changed over the past couple of years. No longer do I engineer systems to make the big brown trucks go faster, now I engineer FUN!