Mark A Reynolds

US Patent:

6673611, Jan 6, 2004

Filed:

May 25, 2001

Appl. No.:

09/866316

Inventors:

James Thompson - Lafayette CO
Leonid Beigelman - Longmont CO
James McSwiggen - Boulder CO
Alexander Karpeisky - Lafayette CO
Laurent Bellon - Frederick MD
Mark Reynolds - Pleasanton CA
Michael Zwick - Madison WI
Thale Jarvis - Boulder CO
Tod Woolf - Sudbury MA
Peter Haeberli - Berthoud CO

Assignee:

Sirna Therapeutics, Inc. - Boulder CO

International Classification:

C12Q 168

US Classification:

435455, 435 6, 435 911, 435366, 536 231, 536 245

Abstract:

This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.

US Patent:

7080031, Jul 18, 2006

Filed:

Feb 1, 2002

Appl. No.:

10/060412

Inventors:

James Q. Crowe - Denver CO, US
Russell A Rushmeier - Mount Kisco NY, US
Indraneel Das - East Hartford CT, US
Paul J. Koster - Broomfield CO, US
Jose F. Alvarez - Denver CO, US
Mark A. Reynolds - Superior CO, US
Lorraine Lotosky - Longmont CO, US

Assignee:

Level 3 Communications, LLC - Broomfield CO

International Classification:

G06F 17/60

US Classification:

705 35, 705 42, 705 43, 705 53, 370352, 370404, 370462, 370463, 370468, 370471, 455453

Abstract:

A method and computer program product are presented for selecting and arranging an appropriate combination of network components, or elements, in a communications network. The selection of network components is done in a manner that maximizes the net present value of cash flow resulting from the provision of communications services between nodes of the network. The method comprises the steps of receiving information that constrains network design and price establishment, and then using the constraint information to select a combination of network components for each link in the communications network. According to the invention, the selection of network components is performed for each of several successive time periods, effectively planning the evolution of the network. The selections are made so that the network components satisfy demand over time while maximizing the net present value of the cash flow that results from the provision of communications services.

US Patent:

7229094, Jun 12, 2007

Filed:

May 25, 2004

Appl. No.:

10/853426

Inventors:

Steven R. Miller - Clarkston MI, US
Mark P. Reynolds - Birmingham MI, US
James Eckelberry - Canton OH, US
Robert P. Carlstedt - Rochester Hills MI, US
Daniel G. Chien - Franklin MI, US
Kenneth G. Lang - Davison MI, US
Martin Peaker - Upton, GB
Nancy L. Saxon - Oakland Township MI, US
Jos Timmermann - Oak Park MI, US
Jeff Lloyd - Auburn Hills MI, US
James Grant - Royal Oak MI, US
Richard M. Clisch - Canton MI, US

Assignee:

ArvinMeritor Technology, LLC - Troy MI

International Classification:

B60G 5/00

US Classification:

280677, 280124107

Abstract:

A tandem axle suspension assembly includes a pair of walking beams disposed substantially parallel to a vehicle longitudinal axis supporting first and second axles. A link plate is pivotally attached to each of the walking beams and is pivotal about an axis transverse to the longitudinal axis. A first and a second link include pivotal connections between the link plate and a vehicle frame member. Vertical movement of the walking beams causes a corresponding rotation of the link plate to compensate for longitudinal displacement of the pivotal links with the first and second links and minimize longitudinal displacement of the walking beams.

US Patent:

7553830, Jun 30, 2009

Filed:

Apr 14, 2005

Appl. No.:

10/966174

Inventors:

Leonid Beigelman - Longmont CO, US
Alexander Karpeisky - Layfayette CO, US
Peter Haeberli - Berthoud CO, US
David Sweedler - Louisville CO, US
Mark Reynolds - Pleasanton CA, US
Nilabh Chaudhary - Superior CO, US
John Min - Longmont CO, US

Assignee:

Sirna Therapeutics, Inc. - San Francisco CA

International Classification:

A61K 31/26
C07J 9/00

US Classification:

514182, 552506

Abstract:

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

US Patent:

20030035829, Feb 20, 2003

Filed:

Jul 23, 1998

Appl. No.:

09/122588

Inventors:

SEAN C. SEMPLE - VANCOUVER, CA
SANDRA K. KLIMUK - NORTH VANCOUVER, CA
PETER SCHERRER - VANCOUVER, CA
MICHAEL J. HOPE - VANCOUVER, CA
YUAN-PENG ZHANG - VANCOUVER, CA
MARK REYNOLDS - LAFAYETTE CO, US
JOHN MIN - BOULDER CO, US

Assignee:

TOWNSEND AND TOWNSEND AND CREW

International Classification:

A61K048/00
A61K009/127
C12N015/88

US Classification:

424/450000, 435/458000, 514/044000

Abstract:

The present invention relates to compositions and methods for delivering nucleic acid catalysts e.g., vascular endothelial growth factor receptor (VEGF-R-1) ribozyme, into a biological system.

US Patent:

20030073640, Apr 17, 2003

Filed:

Dec 21, 2001

Appl. No.:

10/036916

Inventors:

Leonid Beigelman - Longmont CO, US
Alexander Karpeisky - Layfayette CO, US
Peter Haeberli - Berthoud CO, US
David Sweedler - Louisville CO, US
Mark Reynolds - Pleasanton CA, US
Nilabh Chaudhary - Moreland Hills CO, US
John Min - Thornton CO, US

Assignee:

Ribozyme Pharmaceuticals, Inc.

International Classification:

A61K038/05
C11C003/00

US Classification:

514/019000, 554/052000, 564/152000

Abstract:

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

US Patent:

20050176018, Aug 11, 2005

Filed:

Nov 17, 2003

Appl. No.:

10/715285

Inventors:

James Thompson - Lafayette CO, US
Leonid Beigelman - Longmont CO, US
James McSwiggen - Boulder CO, US
Alexander Karpeisky - Lafayette CO, US
Laurent Bellon - Foster City CA, US
Mark Reynolds - Pleasanton CA, US
Michael Zwick - Monticello WI, US
Thale Jarvis - Boulder CO, US
Tod Woolf - Natick MA, US
Peter Haeberli - Berthoud CO, US

Assignee:

Sirna Therapeutics, Inc. - Boulder CO

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.

US Patent:

20050263986, Dec 1, 2005

Filed:

May 26, 2004

Appl. No.:

10/853956

Inventors:

Steven Miller - Clarkston MI, US
Mark Reynolds - Birmingham MI, US
James Eckelberry - Canton OH, US
Robert Carlstedt - Rochester Hills MI, US
Daniel Chien - Franklin MI, US
Kenneth Lang - Davison MI, US
Martin Peaker - Upton, GB
Nancy Saxon - Oakland Township MI, US
Jos Timmermans - Ortonville MI, US
Jeff Lloyd - Auburn Hills MI, US

International Classification:

B60G005/00

US Classification:

280683000

Abstract:

A vehicle suspension assembly includes a control rod pivotally connected between a vehicle frame and an axle. The control rod controls longitudinal and vertical movement of the axle. A spring member is pivotally connected to the frame and fixed to the axle. Air spring assemblies are mounted between the axle and frame. The rigidly mounted spring member exerts torsion forces on the axle to counter roll forces and the air spring assemblies provide favorable ride characteristics adaptable to various trailer load conditions.

Author:

Mark A Reynolds

ISBN #:

0595265154

Author:

Mark C. Reynolds

ISBN #:

0789701820

Author:

Mark C. Reynolds

ISBN #:

0789707896

Author:

Mark C. Reynolds

ISBN #:

0789709430

Author:

Mark A. Reynolds

ISBN #:

0198537689

Author:

Mark A. Reynolds

ISBN #:

0198537697

Author:

Mark W. Reynolds

ISBN #:

0566085119

Author:

Mark Reynolds

ISBN #:

0471961302