Mark E Reynolds

US Patent:

6667318, Dec 23, 2003

Filed:

Nov 26, 2001

Appl. No.:

09/994546

Inventors:

Daniel J. Burdick - Burlingame CA
Mark S. Stanley - Pacifica CA
David Oare - Belmont CA
Mark E. Reynolds - Millbrae CA
Thomas R. Gadek - Oakland CA
James C. Marsters - Oakland CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 314525

US Classification:

514326, 546214, 548182, 548200, 548517, 549473, 514365, 514369, 514422

Abstract:

The invention relates to novel compounds having formula (I) wherein Cy, X, Y, L and R are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation and autoimmune diseases.

US Patent:

6706753, Mar 16, 2004

Filed:

Dec 6, 2002

Appl. No.:

10/313147

Inventors:

Dean R. Artis - Kensington CA
David Y. Jackson - San Bruno CA
Thomas E. Rawson - Mountain View CA
Mark E. Reynolds - Millbrae CA
Daniel P. Sutherlin - South San Francisco CA
Mark S. Stanley - Pacifica CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 314025

US Classification:

514422, 548517, 548537, 548538, 514423

Abstract:

Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, R to R , m and n are as defined herein. Compounds of the invention bind to integrin receptors and thereby inhibit binding of ligands for integrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with integrins or their ligands.

US Patent:

6872735, Mar 29, 2005

Filed:

Jul 11, 2003

Appl. No.:

10/618178

Inventors:

Daniel J. Burdick - Burlingame CA, US
Mark S. Stanley - Pacifica CA, US
David Oare - Belmont CA, US
Mark E. Reynolds - Millbrae CA, US
Thomas R. Gadek - Oakland CA, US
James C. Marsters - Oakland CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K031/4525
C07D405/12

US Classification:

514326, 546214, 546225, 548200, 548517, 548537, 514330, 514365, 514422, 514423

Abstract:

The invention relates to novel compounds having formula (I) wherein Cy, X, Y, L and Rare as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation and autoimmune diseases.

US Patent:

6933314, Aug 23, 2005

Filed:

Sep 30, 2003

Appl. No.:

10/676706

Inventors:

Dean R. Artis - Kensington CA, US
David Y. Jackson - San Bruno CA, US
Thomas E. Rawson - Mountain View CA, US
Mark E. Reynolds - Millbrae CA, US
Daniel P. Sutherlin - South San Francisco CA, US
Mark S. Stanley - Pacifica CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K031/403
C07D209/82

US Classification:

514411, 548440, 548444

Abstract:

Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, Rto R, m and n are as defined herein. Compounds of the invention bind to αintegrin receptors and thereby inhibit binding of ligands for αintegrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with αintegrins or their ligands.

US Patent:

7101851, Sep 5, 2006

Filed:

Sep 26, 2001

Appl. No.:

10/381112

Inventors:

Henry B. Lowman - El Granada CA, US
Gerald R. Nakamura - San Francisco CA, US
Mark E. Reynolds - Millbrae CA, US
Melissa A. Starovasnik - San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 38/03
A61K 38/16
C07K 4/00
C07K 14/00

US Classification:

514 12, 436513, 514 13, 514 14, 530324, 530325, 530326

Abstract:

The invention provides novel compounds which bind to the high affinity receptor for immunoglobulin E (IgE) designated FcεRI and methods for identifying and preparing such compounds. In particular aspects, the invention provides to the treatment of disorders mediated by IgE utilizing the novel compounds of the invention. The invention also provides composition, such as pharmaceutical compositions, comprising the novel compounds, as well as for their use in research, diagnostic, therapeutic, and prophylactic methods.

US Patent:

7229094, Jun 12, 2007

Filed:

May 25, 2004

Appl. No.:

10/853426

Inventors:

Steven R. Miller - Clarkston MI, US
Mark P. Reynolds - Birmingham MI, US
James Eckelberry - Canton OH, US
Robert P. Carlstedt - Rochester Hills MI, US
Daniel G. Chien - Franklin MI, US
Kenneth G. Lang - Davison MI, US
Martin Peaker - Upton, GB
Nancy L. Saxon - Oakland Township MI, US
Jos Timmermann - Oak Park MI, US
Jeff Lloyd - Auburn Hills MI, US
James Grant - Royal Oak MI, US
Richard M. Clisch - Canton MI, US

Assignee:

ArvinMeritor Technology, LLC - Troy MI

International Classification:

B60G 5/00

US Classification:

280677, 280124107

Abstract:

A tandem axle suspension assembly includes a pair of walking beams disposed substantially parallel to a vehicle longitudinal axis supporting first and second axles. A link plate is pivotally attached to each of the walking beams and is pivotal about an axis transverse to the longitudinal axis. A first and a second link include pivotal connections between the link plate and a vehicle frame member. Vertical movement of the walking beams causes a corresponding rotation of the link plate to compensate for longitudinal displacement of the pivotal links with the first and second links and minimize longitudinal displacement of the walking beams.

US Patent:

7234741, Jun 26, 2007

Filed:

Mar 7, 2006

Appl. No.:

11/368998

Inventors:

Mark Reynolds - Madison Heights MI, US
Jeffery Tessmer - Berkley MI, US
Richard Eschebach - GrossePointe Shores MI, US
Ronald Zak - Rochester Hills MI, US

Assignee:

Nissan Technical Center North America, Inc. - Farmington Hills MI

International Classification:

B60R 19/34

US Classification:

293117, 293132

Abstract:

A vehicle bumper assembly includes an elongated energy absorbing member, a plurality of mounting members, a wiring harness and a bumper fascia. The elongated energy absorbing member is dimensioned to extend between first and second sides of a vehicle. The energy absorbing member has an inboard facing surface, an outboard facing surface and an upper surface disposed between the inboard and outboard facing surfaces. The mounting members are longitudinally spaced along the upper surface of the energy absorbing member, each of the mounting members having a wire attachment structure. The wiring harness is coupled to the wire attachment structures of the mounting members such that the wiring harness is supported longitudinally above the upper surface of the energy absorbing member at the mounting members. The bumper fascia fits over the energy absorbing member thereby concealing the wiring harness.

US Patent:

7265146, Sep 4, 2007

Filed:

Apr 20, 2005

Appl. No.:

11/111105

Inventors:

Dean R. Artis - Kensington CA, US
David Y. Jackson - San Bruno CA, US
Thomas E. Rawson - Mountain View CA, US
Mark E. Reynolds - Millbrae CA, US
Daniel P. Sutherlin - South San Francisco CA, US
Mark S. Stanley - Pacifica CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 31/403
C07D 207/04
C07D 209/82

US Classification:

514411, 548427, 548439, 548440, 548444, 548530, 548537, 548538, 514408, 514423

Abstract:

Provided are compounds of formula (I).

Author:

Mark A Reynolds

ISBN #:

0595265154

Author:

Mark C. Reynolds

ISBN #:

0789701820

Author:

Mark C. Reynolds

ISBN #:

0789707896

Author:

Mark C. Reynolds

ISBN #:

0789709430

Author:

Mark A. Reynolds

ISBN #:

0198537689

Author:

Mark A. Reynolds

ISBN #:

0198537697

Author:

Mark W. Reynolds

ISBN #:

0566085119

Author:

Mark Reynolds

ISBN #:

0471961302