Mark Joseph Reynolds

Author:

Mark A Reynolds

ISBN #:

0595265154

Author:

Mark C. Reynolds

ISBN #:

0789701820

Author:

Mark C. Reynolds

ISBN #:

0789707896

Author:

Mark C. Reynolds

ISBN #:

0789709430

Author:

Mark A. Reynolds

ISBN #:

0198537689

Author:

Mark A. Reynolds

ISBN #:

0198537697

Author:

Mark W. Reynolds

ISBN #:

0566085119

Author:

Mark Reynolds

ISBN #:

0471961302

US Patent:

6380169, Apr 30, 2002

Filed:

Aug 31, 1994

Appl. No.:

08/299931

Inventors:

Thomas H. Adams - Rancho Santa Fe CA
Mark A. Reynolds - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A01M 4304

US Classification:

514 44

Abstract:

Compositions, formulations and methods for inhibiting messenger RNA translation using anti-sense oligonucleosides containing 5â-cap cleavage moieties are described.

US Patent:

8399222, Mar 19, 2013

Filed:

Nov 25, 2009

Appl. No.:

12/625609

Inventors:

Amara Siva - Oceanside CA, US
Mark Alan Reynolds - Carlsbad CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12P 19/34
C12Q 1/68

US Classification:

435 912, 435 612

Abstract:

Compositions and methods are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and methods provide for sensitive and specific detection of the target nucleic acids. The compositions and methods include using one or more of a first amplification oligomer that is preferably an extender primer, a target capture oligomer that is preferably at least partially double stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer and a detection probe. The compositions and methods are useful for diagnostics, prognostics, monitoring the effectiveness of treatment and/or determining a treatment.

US Patent:

20130260368, Oct 3, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/823551

Inventors:

Reinhold Pollner - San Diego CA, US
Mehrdad Majlessi - Escondido CA, US
Susan Yamagata - San Diego CA, US
Michael M. Becker - San Diego CA, US
Mark Reynolds - Carlsbad CA, US
Lyle Arnold - Poway CA, US

Assignee:

GEN-PROBE INCORPORATED - San Diego CA

International Classification:

C12Q 1/70

US Classification:

435 5, 536 254, 435 912, 435 611, 536 231

Abstract:

The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.

US Patent:

60604565, May 9, 2000

Filed:

Oct 27, 1997

Appl. No.:

8/960111

Inventors:

Lyle J. Arnold - Poway CA
Mark A. Reynolds - San Diego CA
Cristina Giachetti - Solano Beach CA
Alexandre V. Lebedev - San Diego CA

Assignee:

Genta Incorporated - Lexington MA

International Classification:

C12Q 168
A01N 4304
C07H 1900
C07H 2100

US Classification:

514 44

Abstract:

Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.

US Patent:

55996671, Feb 4, 1997

Filed:

Sep 23, 1994

Appl. No.:

8/311289

Inventors:

Lyle J. Arnold - San Diego CA
Norman C. Nelson - San Diego CA
Mark A. Reynolds - La Jolla CA
Alexander A. Waldrop - San Diego CA

Assignee:

Gen-Probe Incorporated - Sna Diego CA

International Classification:

C12Q 168
C12N 1510

US Classification:

435 6

Abstract:

Described herein is the use of polycationic solid supports in the purification of nucleic acids from solutions containing contaminants. The nucleic acids non-covalently bind to the support without significant binding of contaminants permitting their separation from the contaminants. The bound nucleic acids can be recovered from the support. Also described is the use of the supports as a means to separate polynucleotides and hybrids thereof with a nucleotide probe from unhybridized probe. Assays for target nucleotide sequences are described which employ this separation procedure.

US Patent:

62620363, Jul 17, 2001

Filed:

Jan 24, 2000

Appl. No.:

9/490774

Inventors:

Lyle J. Arnold - Poway CA
Mark A. Reynolds - San Diego CA
Cristina Giachetti - Solana Beach CA

Assignee:

Genta Incorporated - Lexington MA

International Classification:

A01N 6100
A01N 4304
C07H 1900
C07H 2101
C07H 2102

US Classification:

514 44

Abstract:

Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.

US Patent:

56567448, Aug 12, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/490109

Inventors:

Lyle J. Arnold - San Diego CA
Mark A. Reynolds - San Diego CA
Ram S. Bhatt - San Diego CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 100

US Classification:

536 253

Abstract:

A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

US Patent:

55854818, Dec 17, 1996

Filed:

Jan 14, 1994

Appl. No.:

8/182666

Inventors:

Lyle J. Arnold - San Diego CA
Mark A. Reynolds - San Diego CA
Ram S. Bhatt - San Diego CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 102
C07H 1900
C07H 2100

US Classification:

536 2533

Abstract:

A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.