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Mahin D Maines

age ~83

from Rochester, NY

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Also known as:
  • Mahin D Mayer
  • Mahin Maines Mayer
  • Mahin D Malnes
  • Doctor Maines
  • Mahi D Mayer
  • Mayer Mahin Maines
  • Mahin R
  • Robert Mayer
  • Robert Maines Mayer
Phone and address:
235 Huntington Hills Ctr, Rochester, NY 14622
585 266-7469
Related to:
Connected to:

Mahin Maines Phones & Addresses

  • 235 Huntington Hills Ctr, Rochester, NY 14622 • 585 266-7469
  • Irondequoit, NY
  • Lyme, NH
  • Durango, CO
  • Dobbs Ferry, NY

Work

  • Company:
    University of rochester
  • Position:
    Professor

Education

  • Degree:
    Associate degree or higher

Skills

University Teaching • Science • Teaching • Higher Education • Student Affairs • Theory • Student Development • College Teaching

Industries

Higher Education

Us Patents

  • Methods Of Modifying Insulin Signaling Using Biliverdin Reductase

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  • US Patent:
    8455427, Jun 4, 2013
  • Filed:
    Feb 21, 2006
  • Appl. No.:
    11/816557
  • Inventors:
    Mahin D. Maines - Rochester NY, US
  • Assignee:
    University of Rochester - Rochester NY
  • International Classification:
    A61K 38/04
  • US Classification:
    514 11, 530300, 530330
  • Abstract:
    The present invention relates to a method of modulating insulin signaling in a cell. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modulates insulin signaling in the cell via biliverdin reductase interaction with one or both of insulin receptor kinase domain and insulin receptor substrate. Also disclosed are methods of treating a condition associated with insulin signaling and treating a patient for a condition associated with insulin-mediated glucose uptake.

  • Methods Of Modifying Cell Structure And Remodeling Tissue

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  • US Patent:
    20030027124, Feb 6, 2003
  • Filed:
    Jan 14, 2002
  • Appl. No.:
    10/045545
  • Inventors:
    Mahin Maines - Rochester NY, US
  • International Classification:
    A01N001/00
    A01N001/02
    C12N009/00
  • US Classification:
    435/001100, 435/183000
  • Abstract:
    Disclosed is a method of modifying cell structure which includes: increasing the intracellular concentration of biliverdin reductase, or a fragment or variant thereof, in a mammalian cell under conditions effective to modify the structure of the mammalian cell. Also disclosed are methods of performing in vivo tissue remodeling in a mammal and repairing a damaged organ or organ system, both of which include delivering biliverdin reductase, or fragments or variants thereof, to one or more cells present at a site of tissue remodeling in a mammal, wherein said delivering increases the intracellular concentration of biliverdin reductase, or fragments or variants thereof, under conditions effective to modify the structure of the one or more cells at the site of tissue remodeling, thereby remodeling the tissue containing the one or more cells.

  • Methods Of Modulating Heme Oxygenase-1 Expression And Treating Heme Oxygenase-1 Mediated Conditions

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  • US Patent:
    20050119205, Jun 2, 2005
  • Filed:
    Dec 20, 2002
  • Appl. No.:
    10/499243
  • Inventors:
    Mahin Maines - Rochester NY, US
  • International Classification:
    A61K048/00
    C12N009/06
    C12N015/85
  • US Classification:
    514044000, 435455000, 435191000
  • Abstract:
    A method of modifying heme oxygenase-1 transcription is disclosed. The method includes modifying the nuclear concentration of biliverdin reductase, or fragments or variants thereof which bind to a heme oxygenase-1 regulatory sequence, in a cell, whereby an increase in the nuclear concentration of biliverdin reductase, or fragments or variants thereof, increases the transcription of heme oxygenase-1 and a decrease in the nuclear concentration of biliverdin reductase, or fragments or variants thereof, decreases the transcription of heme oxygenase-1.

  • Methods Of Modifying Cell Structure And Remodeling Tissue

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  • US Patent:
    20050287130, Dec 29, 2005
  • Filed:
    Aug 17, 2005
  • Appl. No.:
    11/205562
  • Inventors:
    Mahin Maines - Rochester NY, US
  • Assignee:
    University of Rochester - Rochester NY
  • International Classification:
    A61K048/00
    A61K038/44
    A61K009/127
  • US Classification:
    424093210, 424450000, 424094400
  • Abstract:
    Disclosed is a method of modifying cell structure which includes: increasing the intracellular concentration of biliverdin reductase, or a fragment or variant thereof, in a mammalian cell under conditions effective to modify the structure of the mammalian cell. Also disclosed are methods of performing in vivo tissue remodeling in a mammal and repairing a damaged organ or organ system, both of which include delivering biliverdin reductase, or fragments or variants thereof, to one or more cells present at a site of tissue remodeling in a mammal, wherein said delivering increases the intracellular concentration of biliverdin reductase, or fragments or variants thereof, under conditions effective to modify the structure of the one or more cells at the site of tissue remodeling, thereby remodeling the tissue containing the one or more cells.

  • Biliverdin Reductase Fragments And Variants, And Methods Of Using Biliverdin Reductase And Such Fragments And Variants

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  • US Patent:
    20050287132, Dec 29, 2005
  • Filed:
    Aug 15, 2005
  • Appl. No.:
    11/204187
  • Inventors:
    Mahin Maines - Rochester NY, US
  • Assignee:
    University of Rochester - Rochester NY
  • International Classification:
    A61K038/44
    A61K048/00
  • US Classification:
    424094400, 514044000
  • Abstract:
    One aspect of the present invention relates to a method of regulating protein kinase C activity that includes contacting human protein kinase C selected from the group of isozymes α, β, and γ with a mammalian biliverdin reductase or a fragment thereof with protein kinase C regulatory activity.

  • Methods Of Modulating Cell Cycle And Cell Signaling Pathways Using Biliverdin Reductase

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  • US Patent:
    20070117769, May 24, 2007
  • Filed:
    Sep 29, 2004
  • Appl. No.:
    10/584886
  • Inventors:
    Mahin Maines - Rochester NY, US
  • International Classification:
    A61K 48/00
    C07H 21/04
    C12N 9/06
  • US Classification:
    514044000, 435455000, 435325000, 435320100, 536023200, 435191000
  • Abstract:
    The present invention relates to a method of modifying expression of cell cycle or cell signaling proteins. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modifies the transcription or expression of cell cycle or cell signaling proteins.

  • Use Of Biliverdin Reductase (Bvr) And Bvr Peptide Fragments To Treat Coronary Disorders

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  • US Patent:
    20100303790, Dec 2, 2010
  • Filed:
    May 6, 2010
  • Appl. No.:
    12/775218
  • Inventors:
    Mahin D. Maines - Rochester NY, US
  • Assignee:
    UNIVERSITY OF ROCHESTER - Rochester NY
  • International Classification:
    A61K 38/44
    A61K 31/7088
    A61P 9/00
    C12N 9/02
  • US Classification:
    424 944, 514 44 R, 514 44 A, 435189
  • Abstract:
    The present invention relates to methods and compositions for treating coronary disorders and preventing cardiac cell death that involve the use of biliverdin reductase (“BVR”) or BVR peptides to stabilize the expression and activity of intracellular HO-2 in cardiac cells. The present invention also relates to methods and compositions for inducing cancer cell death in a patient having cancer that involve the use of inhibitory BVR peptides to destabilize intracellular HO-2 expression and activity, thereby augmenting cell death.

  • Use Of Human Biliverdin Reductase And Fragments Thereof For The Treatment Of Protein Kinase C-Delta And Erk Related Conditions

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  • US Patent:
    20110217279, Sep 8, 2011
  • Filed:
    Nov 8, 2010
  • Appl. No.:
    12/941883
  • Inventors:
    Mahin D. MAINES - Rochester NY, US
  • Assignee:
    UNIVERSITY OF ROCHESTER - Rochester NY
  • International Classification:
    A61K 38/44
    C12N 5/00
    A61P 3/10
    A61P 35/00
    A61P 9/10
    A61P 37/00
    A61K 31/713
    C12N 9/02
  • US Classification:
    424 944, 435375, 514 44 A, 435189
  • Abstract:
    The present invention is directed to methods of modulating PKC-δ activity and PKC-δ/ERK complex activity in cells via biliverdin reductase. Methods and compositions for diagnosing and treating a PKC-δ and PKC-δ/ERK complex related condition are also disclosed.

Isbn (Books And Publications)

  • Nitric Oxide Synthase Vol. 31 : Characterization And Functional Analysis

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  • Author:
    Mahin D. Maines
  • ISBN #:
    0121853012

  • Current Protocols In Toxicology

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  • Author:
    Mahin D. Maines
  • ISBN #:
    0471241067

  • Heme Oxygenase: Clinical Applications And Functions

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  • Author:
    Mahin D. Maines
  • ISBN #:
    0849354080

Resumes

Mahin Maines Photo 1

Professor

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Location:
Rochester, NY
Industry:
Higher Education
Work:
University of Rochester
Professor
Skills:
University Teaching
Science
Teaching
Higher Education
Student Affairs
Theory
Student Development
College Teaching
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