Disclosed herein are apparatuses and methods for treating a neurological disorder associated with excessive neuronal excitability (e.g., epilepsy). Methods disclosed herein comprise administering to a subject in need of such treatment an antiepileptic drug solution comprising a therapeutically effective amount of an antiepileptic drug (e.g., a toxin that inhibits the exocytosis of neurotransmifters, excitotoxins, etc.) using convection-enhanced delivery (CED).
Ganaxolone For Use In Treatment Of Status Epilepticus
- RADNOR PA, US Maciej GASIOR - Radnor PA, US Lorianne MASUOKA - Radnor PA, US Julia TSAI - Radnor PA, US Joseph HULIHAN - Radnor PA, US Alex AIMETTI - Radnor PA, US
International Classification:
A61K 31/573 A61K 9/00 A61P 25/08
Abstract:
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
Ganaxolone For Use In Treatment Of Status Epilepticus
- Radnor PA, US Maciej GASIOR - Radnor PA, US Lorianne MASUOKA - Radnor PA, US Julia TSAI - Radnor PA, US Joseph HULIHAN - Radnor PA, US Alex AIMETTI - Radnor PA, US
International Classification:
A61K 31/573 A61P 25/08 A61K 9/00
Abstract:
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
Marinus Pharma
Executive Director, Clinical Development
Teva Pharmaceuticals Apr 2016 - Mar 2018
Senior Director, Global Clinical Development Lead; Cns and Pain
Teva Pharmaceuticals Feb 2014 - Apr 2016
Director, Clinical Project Physician; Cns and Pain
Bristol-Myers Squibb Sep 2011 - Nov 2013
Medical Director, Translational Medicine; Cns and Pain
Cephalon Jan 2010 - Sep 2011
Associate Medical Director, Clinical Research
Education:
Harvard Medical School 2000 - 2003
School of Medicine, Lublin, Poland 1992 - 1994
Doctorates, Doctor of Philosophy, Pharmacology
School of Medicine, Lublin, Poland 1985 - 1992
Doctor of Medicine, Doctorates
Skills:
Neuroscience Clinical Trials Pharmacology Clinical Research Drug Development Life Sciences Clinical Development Medicine Psychiatry Drug Discovery Biotechnology Pain Management Translational Research Clinical Pharmacology Neurology Cognition Cro Neurodegeneration In Vivo Immunology Infectious Diseases Medical Writing Lifesciences Animal Models Medical Affairs Biomarkers Biopharmaceuticals Neuropharmacology Therapeutic Areas Cro Management Translational Medicine
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