Luigi C Adamo

US Patent:

20090209039, Aug 20, 2009

Filed:

Feb 12, 2009

Appl. No.:

12/370146

Inventors:

Andrea Adamo - Cambridge MA, US
Luigi Adamo - Cambridge MA, US
Klavs F. Jensen - Lexington MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12N 15/00
C12M 1/26
C12N 5/06

US Classification:

435455, 4353091, 435375

Abstract:

A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission direction of the jet or droplet) to produce a jet of liquid from the nozzle. The jet or droplet of liquid may be introduced through a cell membrane and into the cell interior in such a way that damage to the cell membrane that would cause cell death is avoided. An electrode may be formed adjacent a fluid channel by conducting a liquid material, such as solder, from a reservoir and into an electrode portion of an electrode channel to a location adjacent the fluid channel. A passageway between the electrode channel and the fluid channel may prevent flow of the liquid electrode material into the fluid channel during electrode formation.

US Patent:

20100190242, Jul 29, 2010

Filed:

Jan 22, 2010

Appl. No.:

12/657555

Inventors:

Andrea Adamo - Cambridge MA, US
Jennifer Lynn Baltz - Cambridge MA, US
Luigi Adamo - Cambridge MA, US

International Classification:

C12M 3/00

US Classification:

4353081

Abstract:

We describe a system for the division or partition of a volume of fluid into droplets of assigned size and subsequent recollection of the drops.

US Patent:

20070249038, Oct 25, 2007

Filed:

Apr 20, 2007

Appl. No.:

11/788646

Inventors:

Andrea Adamo - Cambridge MA, US
Klavs Jensen - Lexington MA, US
Luigi Adamo - Cambridge MA, US

International Classification:

C12M 3/00

US Classification:

435287100

Abstract:

Here we describe an integrated microfluidic chip for delivery of fluids inside or in proximity of individual cells or for measurement of physical quantities. In this device, a cell suspension is pumped through a microchannel in which cells are lined up, pushed on a static microneedle or micropipette, and then collected in a reservoir. The channels are microfabricated. Valves can be embedded in the system to allow fluid flow control thus enhancing the efficiency of the system and reducing malfunctioning due to clogging or any other unexpected issues.