The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present invention also relates to assays for the determination of the presence of osteopontin fragments in samples obtained from subjects and, further, the correlation of osteopontin fragment levels fragment levels with disease detection, progression and prognosis.
The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present invention also relates to assays for the determination of the presence of osteopontin fragments in samples obtained from subjects and, further, the correlation of osteopontin fragment levels fragment levels with disease detection, progression and prognosis.
Inhibiting Breast Cancer Cell Growth By Administering An Intracellular Domain Of Notch2
Maine Medical Research Institute, a division of Maine Medical Center - Scarborough ME
International Classification:
A61K 38/17 A61K 38/18 C07K 14/435 C07K 14/475
US Classification:
4241981, 42419511, 514 2, 514 12, 530350
Abstract:
The present invention relates to the ability of constitutively active Notch 2 to function as an inhibitor of breast cancer. The invention provides methods and compositions for inhibiting breast cancer cells by using hNotch2ICD polypeptides.
Name / Title
Company / Classification
Phones & Addresses
Lucy Liaw Scientist Ii
Maine Medical Center Research Commercial Physical Research
81 Research Dr, Scarborough, ME 04074 207 885-8100
Maine Medical Center
Faculty Scientist Iii and Professor
Maine Medical Center
Senior Scientist
Education:
Vanderbilt University School of Medicine 1994 - 1997
University of Washington 1989 - 1994
Doctorates, Doctor of Philosophy
University of Arizona 1986 - 1989
Bachelors, Bachelor of Science, Biology
Skills:
Cell Culture Molecular Biology Cell Biology Research Biochemistry Western Blotting Cell Transfection Fundraising Data Analysis Cancer Rt Pcr Tissue Culture Transgenic Mice Transgenics Vascular Biology Community Outreach Access Grant Writing Nonprofits