Protein Chemistry • Protein Engineering • Biotechnology • Fluorescence Spectroscopy • Enzymes • Protein Expression • Protein Purification • Biochemistry • Bioinformatics • Computational Biology • Spectroscopy • Laboratory • Protein Protein Interactions • Molecular Cloning • Business Strategy • Entrepreneurship • Molecular Biology • Single Molecule Spectroscopy • Business Development • Life Sciences • Research • Cell Culture
Alice Y. Ting - Allston MA, US David Baker - Seattle WA, US Florian Richter - Seattle WA, US Lucas Nivon - Seattle WA, US Daniel Shao-Chen Liu - Cambridge MA, US
International Classification:
C12P 21/00 C12Q 1/68 C07D 265/38 C12N 9/00
US Classification:
435 61, 435183, 435 681, 544102
Abstract:
The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.
- SEATTLE WA, US Enrique MARCOS - Seattle WA, US Lucas NIVON - Seattle WA, US Gustav OBERDORFER - Seattle WA, US David BAKER - Seattle WA, US Lauren CARTER - Seattle WA, US
International Classification:
C07K 14/47 C07K 17/00 C12N 15/11
Abstract:
Beta-sheet forming polypeptides at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-24 are disclosed, together with their use and methods for designing beta-sheet forming polypeptides.
University of Washington Oct 2014 - Apr 2015
Translational Investigator
Pedalanywhere Jan 2012 - Jan 2015
Co-Founder
University of Washington Oct 2008 - Sep 2014
Post-Doctoral Fellow
Cyrus Biotechnology Oct 2008 - Sep 2014
Chief Executive Officer and Founder
Harvard University Sep 2003 - Sep 2007
Assistant Resident Dean and Resident Tutor
Education:
Harvard University 2002 - 2008
Doctorates, Doctor of Philosophy, Biophysics
Harvard University 1997 - 2001
Bachelors, Bachelor of Arts, Biochemistry
Hunter College High School
Skills:
Protein Chemistry Protein Engineering Biotechnology Fluorescence Spectroscopy Enzymes Protein Expression Protein Purification Biochemistry Bioinformatics Computational Biology Spectroscopy Laboratory Protein Protein Interactions Molecular Cloning Business Strategy Entrepreneurship Molecular Biology Single Molecule Spectroscopy Business Development Life Sciences Research Cell Culture
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Lucas Nivon
Lived:
Seattle, WA
Work:
University of Washington - Postdoctoral Fellow (2008) Harvard University - Zhuang / Shakhnovich Group (2002-2008) Harvard University - Assistant Resident Dean, Cabot House (2003-2007)
Education:
Harvard University - Biophysics, Ph.D., Harvard College - Biochemistry, A.B., Hunter College High School
About:
I grew up in New York City, was at Harvard for school, am now doing computational biochemistry and enjoying life in Seattle, WA.