Louis A Mulieri

US Patent:

51623749, Nov 10, 1992

Filed:

Jun 12, 1991

Appl. No.:

7/714333

Inventors:

Louis A. Mulieri - Hinesburg VT
Gerd Hasenfuss - Wald-Kirch, DE
Norman R. Alpert - Shelburne VT

Assignee:

The University of Vermont and State Agricultural College - Burlington VT

International Classification:

A61K 3115

US Classification:

514640

Abstract:

Muscle activity can be reversibly arrested by administering a reagent, such as 2,3-butanedione monoxime (BDM), which selectively blocks the interaction of the contractile proteins actin and myosin. Muscle such as the heart is contacted with the reagent to arrest activity and, after surgery or transplantation, the reagent is removed from the muscle to restore muscle activity. The preferred reagent BDM has the following structure: ##STR1##.