Louis W Herlands

US Patent:

20060120971, Jun 8, 2006

Filed:

Oct 6, 2005

Appl. No.:

11/244489

Inventors:

David Crockford - Newburyport MA, US
Louis Herlands - Cambridge MA, US

International Classification:

A61K 9/14
A61K 31/19
A61K 48/00
A61K 31/365

US Classification:

424046000, 514044000, 514557000, 514473000

Abstract:

The present invention provides pharmaceutical compositions and methods for intranasal administration to a subject to increase long-chain acyl CoA levels in the CNS (e.g., the hypothalamus), to reduce food intake and/or reduce appetite, to improve hepatic autoregulation, and/or to treat a metabolic disorder such as diabetes mellitus, metabolic syndrome, hyperglycemia, insulin resistance, glucose intolerance and/or obesity.

US Patent:

20070026079, Feb 1, 2007

Filed:

Feb 13, 2006

Appl. No.:

11/353594

Inventors:

Louis Herlands - Cambridge MA, US
Luciano Rossetti - Bedford Hills NY, US
Alessandro Pocai - New York NY, US

International Classification:

A61K 31/549
A61K 31/513
A61K 9/14

US Classification:

424489000, 514223200, 514269000

Abstract:

Provided are methods of increasing Kchannel activity in the hypothalamus of a mammal, methods of reducing glucose production in a mammal, methods of reducing peripheral glucose levels in a mammal, methods of reducing triglyceride levels in a mammal, methods of reducing very low density lipoprotein (VLDL) levels in a mammal, methods of methods of reducing gluconeogenesis in the liver of a mammal, methods of treating metabolic disorders such as diabetes, hyperglycemia, insulin resistance, glucose intolerance, metabolic syndrome and/or obesity, and methods of increasing glucose production and peripheral glucose levels in a mammal. Also provided are methods of treating heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyperVLDLemia, atherosclerosis, hypercholesterolemia, hypertension, polycystic ovary syndrome, gonadotropin deficiency and/or amenorrhea.

US Patent:

20030004142, Jan 2, 2003

Filed:

Apr 17, 2002

Appl. No.:

10/124893

Inventors:

Christopher Prior - Rosemont PA, US
Drore Eisen - Cincinnati OH, US
Louis Herlands - Cambridge MA, US

International Classification:

A61K031/60
A61K031/415
A61K031/405
A61K031/192

US Classification:

514/165000, 514/406000, 514/420000, 514/570000

Abstract:

The invention is directed to uses of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment and prevention of cellular abnormalities of the lung or bronchial pathway.

US Patent:

20030004143, Jan 2, 2003

Filed:

Apr 18, 2002

Appl. No.:

10/125218

Inventors:

Christopher Prior - Rosemont PA, US
Drore Eisen - Cincinnati OH, US
Louis Herlands - Cambridge MA, US

International Classification:

A61K031/60
A61K031/415
A61K031/405
A61K031/192

US Classification:

514/165000, 514/406000, 514/420000, 514/570000

Abstract:

The invention is directed to uses of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment and prevention of cellular abnormalities of the female reproductive tract.