Liming Feng K Huang

US Patent:

7271261, Sep 18, 2007

Filed:

Oct 18, 2002

Appl. No.:

10/273487

Inventors:

Kristen L. Arienti - La Mesa CA, US
Frank U. Axe - Escondido CA, US
J. Guy Breitenbucher - Escondido CA, US
Liming Huang - San Diego CA, US
Alice Lee - San Diego CA, US
Kelly J. McClure - San Diego CA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D 235/18
C07D 471/04
C07D 401/04
A61K 31/4184

US Classification:

544139, 544364, 544370, 5462734, 5483097, 5483101, 5483104, 5483107, 5483117

Abstract:

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.

US Patent:

7465808, Dec 16, 2008

Filed:

Sep 19, 2005

Appl. No.:

11/230200

Inventors:

Terrance D. Barrett - Encinitas CA, US
J. Guy Breitenbucher - Escondido CA, US
Laurent Gomez - San Diego CA, US
Michael D. Hack - San Diego CA, US
Liming Huang - San Diego CA, US
Kelly J. McClure - San Diego CA, US
Magda F. Morton - San Diego CA, US
Clark A. Sehon - West Chester PA, US
Nigel P. Shankley - Solana Beach CA, US

Assignee:

Janssen Pharmaceutica, N.V. - Beerse

International Classification:

C07D 231/12
A61K 31/415
A61K 31/4155

US Classification:

5483771, 5483641, 5483644, 514406

Abstract:

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.

US Patent:

7504414, Mar 17, 2009

Filed:

Aug 2, 2007

Appl. No.:

11/832789

Inventors:

Kristen L. Arienti - La Mesa CA, US
Frank U. Axe - Escondido CA, US
J. Guy Breitenbucher - Escondido CA, US
Liming Huang - San Diego CA, US
Alice Lee - San Diego CA, US
Kelly J. McClure - San Diego CA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D 487/04
A61K 31/4188

US Classification:

514303, 546118

Abstract:

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.

US Patent:

7998978, Aug 16, 2011

Filed:

Apr 19, 2007

Appl. No.:

12/299381

Inventors:

Liming Huang - San Diego CA, US
Song Liu - San Diego CA, US
Elizabeth A. Lunney - San Diego CA, US
Simon P. Planken - San Diego CA, US

Assignee:

Pfizer Inc. - Madison NJ

International Classification:

A61K 31/472

US Classification:

514310, 546143

Abstract:

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R, R, Z, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).

US Patent:

8357706, Jan 22, 2013

Filed:

Nov 15, 2010

Appl. No.:

12/946800

Inventors:

Esther Martinborough - San Diego CA, US
Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US

Assignee:

Receptos, Inc. - San Diego CA

International Classification:

A61K 31/4245
A61K 31/5377
A61K 31/454
C07D 271/06
C07D 413/12

US Classification:

514364, 51421018, 5142362, 514326, 544138, 546209, 548131

Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

US Patent:

8362048, Jan 29, 2013

Filed:

Nov 15, 2010

Appl. No.:

12/946819

Inventors:

Esther Martinborough - San Diego CA, US
Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Gregg Alan Timony - Cardiff by the Sea CA, US
Jennifer L. Brooks - Encinitas CA, US
Robert Peach - San Diego CA, US
Fiona Lorraine Scott - San Diego CA, US
Michael Allen Hanson - San Marcos CA, US

Assignee:

Receptos, Inc. - San Diego CA

International Classification:

A61K 31/4245
C07D 271/06

US Classification:

514364, 548131

Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

US Patent:

8501982, Aug 6, 2013

Filed:

Jun 9, 2011

Appl. No.:

13/157264

Inventors:

Marcus F. Boehm - San Diego CA, US
Esther Martinborough - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Liming Huang - San Diego CA, US
Junko Tamiya - Oceanside CA, US
Mark T. Griffith - San Diego CA, US
Thomas Fowler - Melton Mowbray, GB
Andrew Novak - Nottingham, GB
Michael Knaggs - Burton-on-Trent, GB
Premji Meghani - Leicestershire, GB

Assignee:

Receptos, Inc. - San Diego CA

International Classification:

C07C 69/76
A61K 31/235

US Classification:

560 86, 560 84, 560 85, 514533

Abstract:

Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.

US Patent:

8507538, Aug 13, 2013

Filed:

Nov 15, 2010

Appl. No.:

12/946828

Inventors:

Marcus F. Boehm - San Diego CA, US
Esther Martinborough - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Adam Richard Yeager - San Diego CA, US

Assignee:

Receptos, Inc. - San Diego CA

International Classification:

A61K 31/5377
A61K 31/496
A61K 31/454
A61K 31/433
A61K 31/427
A61K 31/426
A61K 31/425
A61K 31/381
C07D 417/12
C07D 417/10
C07D 333/24
C07D 333/22
C07D 333/20
C07D 333/16
C07D 277/30
C07D 277/28
C07D 277/24
C07D 285/12
C07D 285/10
C07D 285/08

US Classification:

514363, 5142368, 514319, 514365, 51425402, 514438, 544367, 544369, 544133, 544134, 546205, 546206, 548136, 548203, 548204, 548205, 549 75, 549 78

Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.