Lihui L Qin

US Patent:

6428985, Aug 6, 2002

Filed:

Nov 30, 1999

Appl. No.:

09/452624

Inventors:

Jonathan S. Bromberg - New York NY
YaoZhong Ding - Forest Hills NY
LiHui Qin - New York NY

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12P 2100

US Classification:

435 6952, 435 691, 435 695, 435440, 435445, 530351, 5303873, 536 235, 536 2352, 536 2372, 536 231, 514 2, 514 8, 514 12

Abstract:

Disclosed is the surprising discovery that a single amino acid provides the demarcation between the immunosuppressive and immunostimulatory properties of the cytokine, IL-10. The present invention thus provides mammalian and human IL-10 genes and polypeptides that have immunosuppressive properties, without immunostimulatory side-effects. Also provided are various methods of using the new IL-10 constructs, both in vitro and in vivo, particularly in sole or combination therapies involving immunosuppression, such as in the treatment of inflammatory diseases and disorders, and in transplantation.