Lianyun Zhao

US Patent:

7511040, Mar 31, 2009

Filed:

Nov 7, 2007

Appl. No.:

11/936380

Inventors:

David B. Belanger - Cambridge MA, US
M. Arshad Siddiqui - Newton MA, US
Timothy J. Guzi - Sudbury MA, US
Patrick J. Curran - Winthrop MA, US
Praveen K. Tadikonda - Norwood MA, US
Blake Hamann - Linthicum MD, US
Panduranga Adulla P. Reddy - Walpole MA, US
Lianyun Zhao - Burlington MA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 471/02

US Classification:

514249, 544350

Abstract:

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions. An illustrative compound of the invention is shown below:.

US Patent:

7511063, Mar 31, 2009

Filed:

Aug 16, 2006

Appl. No.:

11/504869

Inventors:

Yongqi Deng - Newton MA, US
Patrick J. Curran - Winthrop MA, US
Lianyun Zhao - Burlington MA, US
M. Arshad Siddiqui - Newton MA, US
Janeta Popovici-Muller - Waltham MA, US
Jose S. Duca - Cranford NJ, US
Alan W. Hruza - Hackettstown NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Vincent S. Madison - Mountain Lakes NJ, US
Rumin Zhang - Edison NJ, US
Charles W. McNemar - High Bridge NJ, US
Todd W. Mayhood - Randolph NJ, US
William T. Windsor - East Brunswick NJ, US
Emma M. Lees - Oakland CA, US
David A. Parry - Mountain View CA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/47
C07D 215/14

US Classification:

514314, 546168

Abstract:

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

US Patent:

7557104, Jul 7, 2009

Filed:

Jun 5, 2007

Appl. No.:

11/758243

Inventors:

Lianyun Zhao - Burlington MA, US
Panduranga Adulla P. Reddy - Walpole MA, US
Neng-Yang Shih - Warren NJ, US
Kamil Paruch - Garwood NJ, US
Timothy J. Guzi - Chatham NJ, US
M. Arshad Siddiqui - Newton MA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497

US Classification:

514249, 544350, 546184, 5483647, 548518, 549 29

Abstract:

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

US Patent:

7576085, Aug 18, 2009

Filed:

Nov 10, 2005

Appl. No.:

11/272392

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Lianyun Zhao - Burlington MA, US
Patrick J. Curran - Winthrop MA, US
David B. Belanger - Cambridge MA, US
Blake Hamann - Cambridge MA, US
Panduranga A. Reddy - Walpole MA, US
M. Arshad Siddiqui - Newton MA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 403/00
C07D 471/00
C07D 487/00
C07D 491/00
C07D 495/00
C07D 497/00

US Classification:

514249, 544295, 544350

Abstract:

In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An illustrative compound of the invention is shown below:.

US Patent:

8278337, Oct 2, 2012

Filed:

Dec 17, 2007

Appl. No.:

12/519731

Inventors:

David B. Belanger - Cambridge MA, US
M. Arshad Siddiqui - Newton MA, US
Patrick J. Curran - Winthrop MA, US
Blake Hamann - Linthicum MD, US
Lianyun Zhao - Burlington MA, US
Panduranga Adulla P. Reddy - Walpole MA, US
Praveen K. Tadikonda - Norwood MA, US
Umar Faruk Mansoor - Framingham MA, US

Assignee:

Merck Sharp & Dohme - Rahway NJ

International Classification:

A61K 31/44

US Classification:

514354, 544281, 544284, 544333, 544353, 544359, 546118, 546121, 546122, 546152, 546323, 548146, 548152, 5483731

Abstract:

Disclosed are compounds of the formula (I) wherein X is N or CH, and Y is N or CR. Also disclosed are methods of treating JNK and ERK mediated diseases using the compounds of formula 1.

US Patent:

8293747, Oct 23, 2012

Filed:

Jul 17, 2008

Appl. No.:

12/669334

Inventors:

Panduranga Adulla P. Reddy - Walpole MA, US
Lianyun Zhao - Burlington MA, US
Praveen K. Tadikonda - Norwood MA, US
Tzu Tshin Wong - Belmont MA, US
Shuyi Tang - Belmont MA, US
Luis E. Torres - Medford MA, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/506
C07D 401/14
A61K 31/496
A61K 31/497
A61K 31/519
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 487/04
C07D 491/04

US Classification:

51425218, 544295, 544121, 544263, 544280, 544357, 544362, 544363, 544364, 546194

Abstract:

The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.

US Patent:

8318735, Nov 27, 2012

Filed:

Oct 29, 2007

Appl. No.:

12/447710

Inventors:

Cliff C. Cheng - Cambridge MA, US
Xiaohua Huang - Malden MA, US
Thierry O. Fischmann - Scotch Plains NJ, US
Jose S. Duca - Cranford NJ, US
Matthew Richards - Somerville MA, US
Hongbo Zeng - Westford MA, US
Binyuan Sun - Chestnut Hill MA, US
Panduranga Adulla Reddy - Walpole MA, US
Lianyun Zhao - Burlington MA, US
Shuyi Tang - Quincy MA, US
Tzu T. Wong - Belmont MA, US
Praveen K. Tadikonda - Norwood MA, US
Luis E. Torres - Medford MA, US
M. Arshad Siddiqui - Newton MA, US
Michael P. Dwyer - Scotch Plains NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Timothy J. Guzi - Sudbury MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/5355
A61K 31/496
C07D 401/14
C07D 403/14
C07D 413/14

US Classification:

5142358, 51425305, 51425306, 5142531, 544121, 544362, 544364

Abstract:

The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

US Patent:

8476278, Jul 2, 2013

Filed:

Oct 27, 2008

Appl. No.:

12/738487

Inventors:

Panduranga Adulla P. Reddy - Walpole MA, US
Tzu T. Wong - Belmont MA, US
Lianyun Zhao - Burlington MA, US
Shuyi Tang - Belmont MA, US
Marc A. Labroli - Moorestown NJ, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/496
C07D 417/14
A61K 31/427
A61K 31/551
A61K 31/5377
C07D 413/14
C07D 417/12
C07D 471/10

US Classification:

5142531, 514218, 5142335, 514278, 540575, 544 60, 544 61, 544 62, 544121, 544131, 544133, 544364, 546 16

Abstract:

The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.