Liang C Bao

US Patent:

20040077690, Apr 22, 2004

Filed:

Oct 16, 2003

Appl. No.:

10/381929

Inventors:

Bing-Yan Zhu - Palo Alto CA, US
Wenrong Huang - Cupertino CA, US
Penglie Zhang - Foster City CA, US
Zhaozhong Jia - San Mateo CA, US
Liang Bao - San Bruno CA, US
Yanhong Wu - Foster City CA, US
Robert Scarborough - Half Moon Bay CA, US

International Classification:

A61K031/44
A61K031/4015
A61K031/325

US Classification:

514/346000, 514/424000, 514/482000, 546/291000, 548/550000, 560/029000

Abstract:

Novel quaternary amidino-containing compounds of the general formulae (I), (II), (III), (IV), (V) and (VI): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.